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Uridine glucuronosyl transferase

Capiello, M., Guiliani, L., Pacifici, G. M., Distribution of UDP-glucuronosyl transferase and its endogenous substrate uridine 5-diphosphoglucuronic acid in human tissues, Pur. J. Clin. Pharmacol. 1991, 41, 345-350. [Pg.325]

The other primary Phase II metabolic pathway is glucuronidation, which involves the formation ofglucuronic acid conjugates of xenobiotics. This is catalyzed by a family of UDP-glucuronosyl transferases (UGTs) in the presence of uridine diphosphate... [Pg.49]

Quercetin and other flavonols are subject to metabolic conversion during the absorption process in the small intestine. Phase II enzymes including uridine 5 -diphosphate glucuronosyl transferase (UGT), phenol-sulfotransferase (PST),... [Pg.188]

Figure 7.16 Reaction sequences of uridine diphospho glucuronosyl transferase and chemical structures of compounds that form glucuronides. Arrows indicate the position on each molecule where glucuronidation occurs. Figure 7.16 Reaction sequences of uridine diphospho glucuronosyl transferase and chemical structures of compounds that form glucuronides. Arrows indicate the position on each molecule where glucuronidation occurs.
MUk thistle inhibits CYP3A4 and uridine diphospho-glucuronosyl transferase in human hepatocyte cultures (40). [Pg.364]

Polycyclic aromatic amines are readily absorbed into the body via the gastrointestinal tract, where metabolic activation takes place. Aryl amines are N-hydroxylated and subsequently glucuronidated via uridine diphosphate (UDP)-glucuronosyl transferase or sulfated by sulfotransferases, N-acetylation of the amine, and 0-acetylation of the N-hydroxy amine can occur. [Pg.2096]

Smith PA, Sorich MJ, McKinnon RA, Miners JO. In silico insights Chemical and structural characteristics associated with uridine diphosphate-glucuronosyl-transferase substrate selectivity. Clin Exp Pharmacol Physiol 2003 30 836-40. [Pg.288]

Seo BG, Kwon HC, Oh SY et al (2009) Comprehensive analysis of excision repair complementation group 1, glutathione S-transferase, thymidylate synthase and uridine diphosphate glucuronosyl transferase 1A1 polymorphisms predictive for treatment outcome in patients with advanced gastric cancer treated with FOLFOX or FOLFIBI. Oncol Rep 22 127-136... [Pg.321]

UGT lAl uridine diphosphate glucuronosyl transferase lAl TPMT thiopurine methyl transferase SN-38 an active metabolite of ironotecan SN-38G a glucuronide metabolite of SN-38. [Pg.72]

The biotransformation of paracetamol (acetaminophen) at therapeutic concentrations in man can be seen in Figure 1. The major route of metabolism is via conjugation of the phenolic -OH group. The hepatic sulphotransferases have a high affinity for paracetamol (acetaminophen) but are rapidly saturated (either due to cofactor depletion or limited sulphotransferase availability), as were the uridine diphosphate glucuronosyl transferases (UDPGTs) which... [Pg.255]

Abbreviations used in this chapter bp, base pairs FAD, flavine adenine dinucleotide GLO, L-gulono-y-lactone oxidase ODS rat, osteogenic disorder Shionogi rat UDPGT, uridine diphosphate glucuronosyl-transferase. [Pg.19]

See other pages where Uridine glucuronosyl transferase is mentioned: [Pg.44]    [Pg.44]    [Pg.54]    [Pg.130]    [Pg.132]    [Pg.653]    [Pg.290]    [Pg.251]    [Pg.281]    [Pg.85]    [Pg.190]    [Pg.407]    [Pg.138]    [Pg.120]    [Pg.42]    [Pg.472]    [Pg.304]    [Pg.298]    [Pg.238]    [Pg.238]    [Pg.163]    [Pg.47]    [Pg.218]    [Pg.445]    [Pg.1067]    [Pg.30]    [Pg.4309]    [Pg.236]    [Pg.806]    [Pg.221]   
See also in sourсe #XX -- [ Pg.139 ]



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Glucuronosyl transferases

Uridine diphosphate-glucuronosyl transferases

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