Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

UDP-glucuronosyl transferases UGTs

Hyperbilirubinemia Most patients taking atazanavir experience asymptomatic elevations in indirect (unconjugated) bilirubin related to inhibition of UDP-glucuronosyl transferase (UGT). This hyperbilirubinemia is reversible upon discontinuation of atazanavir. [Pg.1829]

The other primary Phase II metabolic pathway is glucuronidation, which involves the formation ofglucuronic acid conjugates of xenobiotics. This is catalyzed by a family of UDP-glucuronosyl transferases (UGTs) in the presence of uridine diphosphate... [Pg.49]

Table 11 Tissue Distribution and Specific Substrates for Human UDP-Glucuronosyl-transferase (UGT) Enzymes... Table 11 Tissue Distribution and Specific Substrates for Human UDP-Glucuronosyl-transferase (UGT) Enzymes...
Table 4 Drug metabolizing enzyme (P450 isoforms (CYP), UDP-glucuronosyl transferase (UGT) and phenol sulfotransferase (PST)) substrates that can be used for the in situ measurement of activity in the human hepatocyte enzyme induction assay. Table 4 Drug metabolizing enzyme (P450 isoforms (CYP), UDP-glucuronosyl transferase (UGT) and phenol sulfotransferase (PST)) substrates that can be used for the in situ measurement of activity in the human hepatocyte enzyme induction assay.
Riedmaier S, Klein K, Hofmann U, Keskitalo JE, Neuvonen PJ, Schwab M, Niemi M, Zanger UM (2010) UDP-glucuronosyl-transferase (UGT) polymorphisms affect atorvastatin lactonization in vitro and in vivo. Clin Pharmacol Ther 87 65-73... [Pg.87]

See other pages where UDP-glucuronosyl transferases UGTs is mentioned: [Pg.277]    [Pg.202]    [Pg.247]    [Pg.274]    [Pg.85]    [Pg.220]    [Pg.102]    [Pg.336]    [Pg.407]    [Pg.138]    [Pg.1250]    [Pg.80]    [Pg.467]    [Pg.460]    [Pg.380]    [Pg.306]    [Pg.30]    [Pg.624]    [Pg.215]   
See also in sourсe #XX -- [ Pg.29 , Pg.44 , Pg.86 , Pg.90 , Pg.161 , Pg.185 , Pg.603 ]



SEARCH



Glucuronosyl transferases

UDP

UDP-glucuronosyl transferases

UGTs

© 2024 chempedia.info