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Human UDP-glucuronosyl transferases,

Sugatani J, Yamakawa K, Tonda E, Nishitani S, Yoshinari K, Degawa M, Abe I, Noguchi H, Miwa M. The induction of human UDP-glucuronosyl-transferase 1A1 mediated through a distal enhancer module by flavonoids and xenobiotics. Biochem Pharmacol 2004 67 989-1000. [Pg.201]

Burchell B, Brierley CH, Ranee D. Specificity of human UDP-glucuronosyl-transferases and xenobiotic glucuronidation. Life Sci 1995 57(20) 1819—1831. [Pg.113]

Munzel PA, Schmohl S, Heel H, et al. Induction of human UDP glucuronosyl-transferases (UGT1A6, UGT1A9, and UGT2B7) by t-butylhydroquinone and 2,3,7, 8-tetrachlorodibenzo-p-dioxin in Caco-2 cells. Drug Metab Dispos 1999 27(5) 569-573. [Pg.118]

Table 11 Tissue Distribution and Specific Substrates for Human UDP-Glucuronosyl-transferase (UGT) Enzymes... Table 11 Tissue Distribution and Specific Substrates for Human UDP-Glucuronosyl-transferase (UGT) Enzymes...
Ciotti, M., Basu, N., Brangi, M., and Owens, I. S. (1999) Glucuronidation of 7-ethyl-lO-hydroxycamptothecin (SN-38) by the human UDP-glucuronosyl-transferases encoded at the UGTl locus. Biochem. Biophys. Res. Commun. 260, 199-202. [Pg.28]

Capiello, M., Guiliani, L., Pacifici, G. M., Distribution of UDP-glucuronosyl transferase and its endogenous substrate uridine 5-diphosphoglucuronic acid in human tissues, Pur. J. Clin. Pharmacol. 1991, 41, 345-350. [Pg.325]

Kostrubsky SE, Sinclair JF, Strom SC, et al. Phenobarbital and phenytoin increased acetaminophen hepatotoxicity due to inhibition of UDP-glucuronosyl transferases in cultured human hepatocytes. Toxicol Sci 2005 87 146-155. [Pg.706]

Table 4 Drug metabolizing enzyme (P450 isoforms (CYP), UDP-glucuronosyl transferase (UGT) and phenol sulfotransferase (PST)) substrates that can be used for the in situ measurement of activity in the human hepatocyte enzyme induction assay. Table 4 Drug metabolizing enzyme (P450 isoforms (CYP), UDP-glucuronosyl transferase (UGT) and phenol sulfotransferase (PST)) substrates that can be used for the in situ measurement of activity in the human hepatocyte enzyme induction assay.
Cheng, Z., Radominska-Panya, A. and Tephly, T.R. (1999) Studies on the substrate specificity of human intestinal UDP-glucuronosyl transferases 1A8 and... [Pg.351]

Fisher, M. B., Paine, M. F., Strelevitz, T. J., and Wrighton, S. A. (2001). The role of hepatic and extrahepatic UDP-glucuronosyl-transferases in human drug metabolism. Drug Metabolism Reviews, 33, 273-297. [Pg.172]

Hett KF, Ethell BT, Maggs JL, Davis TM, Batty KT, Burchell B, Binh TQ, Thu le TA, Hung NC, Pirmohamed M, Park BK, Edwards G. Glucuronidation of dihydroartemisinin in vivo and by human liver microsomes and expressed UDP-glucuronosyl-transferases. Drug Metab Dispos 2002 30 1005-1012. [Pg.315]

Reinach B, de Sousa G, Dostert P, Ings R, Gugenheim J, Rahmani R. Comparative effects of rifabutin and rifampicin on cytochromes P450 and UDP-glucuronosyl-transferases expression in fresh and cryopreserved human hepatocytes. Chem Biol Interact 1999 121 37-48. [Pg.570]

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