Glucocorticoid, receptor

Using the reaction leading to enantiopure 1,2-dihydroquinolines I as an example, this chapter addresses both the principles of asymmetric organocatalysis in the Petasis-type reaction (Sect. 8.3), as well as representative multi-component reactions in organic synthesis (Sect. 8.4). 

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Two zinc-containing motifs in the glucocorticoid receptor form one DNA-binding domain... 

Figure 10.11 Sequence-specific interactions between DNA (yellow) and the recognition helix (red) of the glucocorticoid receptor. Three residues, Lys 461, Val 462 and Arg 466 make specific contacts with the edges of the bases In the major groove.

The individual domains of the two receptors both have structures similar to that of the glucocorticoid receptor, and they bind to DNA in a similar way, with their recognition helices in the major groove. The dimer contacts are, however, totally different. In the glucocorticoid receptor, which binds to a palindromic DNA sequence like the 434 repressor described in Chapter 8, the domains interact symmetrically in a head-to-head fashion equivalent... 

Hard, T., et al. Solution structure of the glucocorticoid receptor DNA-binding domain. Science 249 157-160, 1990. 

Luisi, B.F., et al. Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA. 

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