Dementia Ginkgo biloba

Gnkgo (maiden hair tree, kew tree) Ginkgo biloba Raynauds disease, cerebral insufficiency anxiety, stress, tinnitus, dementias, circulatory problems, asthma Rare if used as directed possible effects include headache, dizziness, heart palpitations, Gl effects, rash, allergic dermatitis Do not take with antidepressant drugs, such as the MAOIs, or the antiplatelet drugs such as coumarin, unless advised to do so by the primary care provider. 

Birks J, Grimley Evans J and Van Dongen M (2003). Ginkgo Biloba for Cognitive Impairment and Dementia (The Cochrane Library No. 1). Update Software, Oxford, UK. 

Kristoikova Z and Klaschka J (1997). In vitro effect of Ginkgo biloba extract (EGb 761) on the activity of presynaptic cholinergic nerve terminals in rat hippocampus. Dementia <6 Geriatric Cognitive Disorders, 8, 43-48. 

Itil T, Martorano D. (1995). Natural substances in psychiatry (Ginkgo biloba in dementia). Psychopharmacol Bull. 31(1) 147-58. 

Itil TM, Eralp E, Ahmed I, Kunitz A, Itil KZ. (1998). The pharmacological effects of ginkgo biloba, a plant extract, on the brain of dementia patients in comparison with tacrine. Psychopharmacol Bull. 34(3) 391-97. 

Kanowski S, Herrmann WM, Stephan K, Wierich W, Hdrr R. (1996). Proof of efficacy of the Ginkgo biloba special extract EGb 761 in outpatients suffering from mild to moderate primary degenerative dementia of the Alzheimer type or multi-infarct dementia. Pharmacopsychiatry. 29(2) 47-56. 

Kristofikova Z, Benesova 0, Tejkalova H. (1992). Changes in high-affinity choline uptake in the hippocampus of old rats after long-term administration of two nootropic drugs (tacrine and Ginkgo biloba extract). Dementia. 3 304-7. 

Le Bars PL, Katz MM, Berman N, Itil TM, Freedman AM, Schatzberg AF. (1997). A placebo-controlled, double-blind, randomized trial of an extract of Ginkgo biloba for dementia. North American EGb Study Group. JAMA. 278(16) 1327-32. 

Maurer K, Ihl R, Dierks T, Frolich L. (1997). Clinical efficacy of Ginkgo biloba special extract EGb 761 in dementia of the Alzheimer type. J Psychiatr Res. 31(6) 645-55. 

We do not recommend the routine use of selegiline, nonsteroidal anti-inflammatory drugs like ibuprofen, or herbs such as ginkgo biloba for patients with dementia. These all have the potential for problematic side effects that may outweigh their benefit. If they are used, please be sure that a physician closely monitors your patient. 

Birks J, Grimley Evans J. (2007) Ginkgo biloba for cognitive impairment and dementia. Cochrane Database Syst Rev 2 CD003120. 

DeKosky ST, Williamson JD, Fitzpatrick AL, Kronmal RA, Ives DG Saxton JA, Lopez OL, Burke G Carlson MC, Fried LP, KuUer LH, Robbins JA, Tracy RP, Woolard NF, Dunn L, Snitz BE, Nahin RL, Furberg CD. (2008) Ginkgo biloba for prevention of dementia A randomized controlled trial. JAMA 300 2253-2262. 

Ernst E, Pittler MH. Ginkgo biloba for dementia a systematic review of doubleblind placebo-controlled trials. Clin Drug Invest 199 17 301-308. 

Le Bars, P.L., Kieser, M., and Itil, K.Z., A 26-week analysis of a double-blind, placebo-controlled trial of the ginkgo biloba extract EGb 761 in dementia. Dement Geriatr Cogn Disord, Jul-Aug, 11(4), 230-237, 2000. 

Kanowski S, Hoerr R. Ginkgo biloba extract EGb 761 in dementia intent-to-treat analyses of a 24-week, multi-center, double-blind, placebo-controlled, randomized trial. Pharmacopsychiatry 2003 36 297-303. 

Weitbrecht WV, Jansen W. Double blind and comparative (Ginkgo biloba versus placebo) therapeutic study in geriatric patients with primary degenerative dementia—a preliminary evaluation. In Agnoli A et al., eds. Effects of Ginkgo biloba Extract on Organic Cerebral Impairment. London John Libbey Eurotext Ltd., 1985. 

Ginkgo biloba Promoted mainly to sharpen mental focus in otherwise healthy adults and also in people with dementia Improvement of blood flow in brain and peripheral circulation... 

Ginkgo biloba (GB) is sold as a dietary supplement in the United States. It is purported to improve blood flow to the brain and to improve peripheral circulation. It is promoted mainly to sharpen mental focus in otherwise healthy adults as well as in those with dementia. Other conditions for which it is currently used are diabetes-related circulatory disorders, impotence, and vertigo. 

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