Antitumor compound

Miscellaneous. Reductioa of a palladium salt by CO is the basis of a visual test for ambieat carboa moaoxide (227). Palladium compouads are used as photographic seasitizers (228). The low dimensional mixed valeace compouad Csq g3[Pd(S2C2(CN)2)] 0.5H2O behaves as a semimetal at room temperature (229). Palladium compouads isostmctural with poteat platiaum antitumor compounds have poor antitumor activity (230). 

V. S. Sethi, in A. As2alos, ed.. Antitumor Compounds ofiNatural Origin Chemisty andBiochemisty, Yol. II, CRC Press, Boca Raton, Fla., 1981, Chapt. 3. 

Kondrat eva pyridine synthesis. This methodology to pyridine rings continues to be applied in total synthesis. An approach to the antitumor compound ellipticine 34 ° makes use of a Diels-Alder reaction of acrylonitrile and oxazole 32 to form pyridiyl derivative 33. Addition of methyllithium and hydrolysis transforms 33 into 34. 

Antitumor compounds, among them cyclic peptides, terpenoids, and alkaloids isolated from higher plants 99YZ529. 

Avidin-biotinic system as the aid of address delivery of antitumor compounds 98MI54. 

Among some 70 new antitumor compounds discovered by H. Umezawa and coworkers, formycin (1966) constituted another important discovery. Produced in conjunction with coformycin, the latter inhibits the activity of adenosine deaminase (1967) and enhances the antitumor activity of formycin. 

Moustatih, A., and Garnier-Suillerot, A. (1989) Bifunctional antitumor compounds synthesis and characterization of a gold(III)-streptonigrin complex with thiol-modulating properties. Journal of Medicinal Chemistry, 32, 1426. 

Mitsunobu conditions are effective for glycosylation of weak nitrogen nucleophiles, such as indoles. This reaction has been used in the synthesis of antitumor compounds. 

In synthetic applications, Li et al. examined the propargylation-allenylation of carbonyl compounds by using a variety of metals including Sn, Zn, Bi, Cd, and In.203 By using the indium-mediated allenylation reaction, Li and co-workers developed the synthesis of the antiviral, antitumor compound (+)-goniofufurone (Scheme 8.22),204 a key component isolated from the Asian trees of the genus Goniothalamus,205 and other styryl lactone derivatives (Eq. 8.80). 

Chandra, P. Molecular Approaches for Designing Antiviral and Antitumor Compounds. 52,... 

Batcho indole synthesis is a useful tool for synthesis of natural products. As outlined in Scheme 10.6, the Batcho indole synthesis is used for total synthesis of the slime mold alkaloid arcyriacy anin.67 Such indolocarbazole alkaloids represent a growing number of natural products isolated from soil organism, slime molds, and marine sources. They are important as antitumor compounds and protein kinase C and topoisomerase inhibitors. 

In the course of investigation of potential antitumor compounds, the triazolobenzodithiazine derivative 37 seemed of special interest (Scheme 4). As no unambiguous proof could be provided by spectroscopic data (cf. Section 11.19.6.) X-Ray analysis of the crystalline product has been carried out <2003BMC1259>. The results revealed that in crystals the molecules formed centrosymmetric dimers by the help of weak NH- N hydrogen bonds. Because of the conformation of the central six-membered ring, the tricyclic molecule had a butterfly shape. 

Many groups have employed a Diels-Alder strategy toward the synthesis of the well-known antitumor compound paclitaxel, which has a tetracyclic core containing two... 

Aldol reactions are among the most prominent and most frequently applied transformations, since they build up polyketide fragments of important biologically active compounds such as antibiotics and antitumor compounds. 

Besmajouirou has a Ph.D. in neurosciences. She is affiliated to the ERT 62 laboratory and holds a position as a researcher in a biopharmaceutical company. She works in the field of animal toxins, antitumor compounds, and antivirals. She has contributed to 10 scientific articles, 6 communications, and 2 patents. 

Pommier Y, Kohlagen G BaiUy C, Waring M, Mazumder A, Kohn K. (1996) DNA sequence- and structure-selective alkylation of guanine N2 in the DNA minor groove by ecteinascidin 743, a potent antitumor compound from the Caribbean tunicate Ecteinascidia turbinata. Biochemistry 35 13303-13309. 

Kim, Y.B., Lee, KH., Sugita, K., Yoshida, M. and Horinouchi, S. (1999) Oxamfiatin is a novel antitumor compound that inhibits mammalian histone deacetylase. Oncogene, 18, 2461—2470. 

Anthracydines (Figure 8.22) are an important group of antitumor compounds that are characterized by a basic structure of 7,8,9,10-tetrahydro-5,12-naphthacene... 

Biggs T, Foreman J, Sundstrom L et al (2011) Antitumor compound testing in glioblastoma organotypic brain cultures. J Biomol Screen 16 805-817... 

Anthracyclines are antitumor quinone containing antibiotics produced by different strains of Streptomyces. Some of them, such as adriamycin doxorubicin), and daunorubicin are broad spectrum antitumor compounds. They act by binding to DNA and interfering with DNA replication and gene transcription. Their limitations for clinical use are cardiac toxicity and drug resistance phenomena. Consequently, intense structure-activity relationship studies have been performed to improve the pharmacological profile as well as to enhance the affinity for DNA. In particular, a number of fluorinated anthracyclines have been prepared with introduction of fluorine atoms into D or A cycles, and into the aglycone side chain linked atC-14. ... 

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