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Genetic toxicology Ames assay

Prenatal and postnatal development primate Genetic toxicology Ames test, micronucleus assay in mice Carcinogenicity none Developmental rats, rabbits Genetic toxicology Ames test, human lymphocyte chromosomal aberration assay Carcinogenicity short-term experiments in rodents (i.e., not standard 2-year study)... [Pg.932]

Fertility and early embryonic development rhesus monkeys Developmental rhesus monkeys Prenatal and postnatal development none Genetic toxicology Ames test, in vitro transformation assay, human peripheral blood lymphocyte assay Carcinogenicity none... [Pg.936]

Single dose cynomolgus monkeys Repeat dose mice, rats, cynomolgus monkeys Fertility and early embryonic development rats Developmental rats, mice, rabbits Prenatal and postnatal development rats Genetic toxicology Ames reverse mutation, Chinese hamster ovary hypoxanthine guanine phosphoribosyl-transferase forward point mutation assay, cytogenetics in human lymphocytes... [Pg.1067]

Lofroth, G, Nilsson, L. Andersen, J.R. (1986) Stracture-activity relationship of nitroalkane-induced mutagenicity in the Ames Salmonella assay. Genetic toxicology of environmental chemicals, Part B Genetic effects and applied mutagenesis. Prog. din. biol. Res., 209B, 149-155... [Pg.500]

The Ames test is recommended by the International Conference on Harmonisation Guidelines as part of a standard genetic toxicology battery. The other assays include the mouse lymphoma and micronucleus tests. This bacterial mutation test may not be appropriate for the evaluation of certain classes of chemicals, for example highly bactericidal compounds (e.g., certain antibiotics), any compounds that may interfere with cell division or replication, and possibly some peptides. In such cases, mammalian mutation tests may be more appropriate. [Pg.91]

The micronucleus assay is one type of study recommended by the FDA Redbook and ICH guidelines as part of a standard genetic toxicology battery. The other assays include the Ames (bacterial reverse mutation) and mouse lymphoma tests. [Pg.1693]

See also Ames Test Federal Insecticide, Fungicide, and Rodenticide Act, US Food and Drug Administration, US Good Laboratory Practices (GLP) International Conference on Harmonisation Micronucleus Assay Genetic Toxicology Toxicity Testing, Mutagenicity Redbook. [Pg.1693]


See other pages where Genetic toxicology Ames assay is mentioned: [Pg.944]    [Pg.1068]    [Pg.206]    [Pg.22]    [Pg.549]    [Pg.588]    [Pg.379]    [Pg.1241]    [Pg.1242]    [Pg.17]    [Pg.276]    [Pg.277]    [Pg.166]    [Pg.146]   
See also in sourсe #XX -- [ Pg.560 ]




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