Genetic control system

The following system has been discussed by Griffith (1971) as a model for a genetic control system. The activity of a certain gene is assumed to be directly induced by two copies of the protein for which it codes. In other words, the gene is stimulated by its own product, potentially leading to an autocatalytic feedback process. In dimensionless form, the equations are... 

A unique feature of the book is its emphasis on applications. These include mechanical vibrations, lasers, biological rhythms, superconducting circuits, insect outbreaks, chemical oscillators, genetic control systems, chaotic waterwheels, and even a technique for using chaos to send secret messages. In each case, the scientific background is explained at an elementary level and closely integrated with the mathematical theory. 

Tsuchiya, M. and Morinaga, Y. (1988) Genetic control systems of Escherichia coli can confer inducible expression of cloned genes in coryneform bacteria. Bio/Technology, 6 (4), 428-430. 

During embryogenesis, however, in the period of most active morphogenesis, the external environment has no regulatory action. Nevertheless, in relation to each particular cell, to each individual nucleus and individual chromosome, many external stimuli which arise in the course of development and in connection with it can exert a specific differentiating action on its genetic controlling system. 

Ratner, V. A., 1966, Genetic Controlling Systems, Izd. Nauka Press, Siberian Branch, Novosibirsk. 

Genetic algorithms and their application to control system design... 

Obviously, regulation of food intake depends on many neurotransmitters and hormones but this final section will outline the role played by central 5-HT transmission in this process. It had been the belief for some time that increased 5-HT transmission in the brain reduces food intake (Blundell 1977) and this certainly explains the satiety in rats that follows infusion of 5-HT into the paraventricular nucleus (PVN) of the hypothalamus. However, recent studies using microdialysis have found that 5-HT efflux in the lateral hypothalamus is itself increased by food intake, suggesting the existence of a feedback control system. In fact, because the increase in 5-HT efflux is greater in genetically obese rats than in their lean counterparts, it has been proposed that there is a deficiency in the 5-HT inhibition of food intake in obesity. 

The immune system is a very complex system with many redundant control systems. One hint of this complexity is that idiopathic lupus has a high genetic component, and there are 48 chromosomal regions that have been linked to the risk of idiopathic lupus yet, the child of a person with lupus only has a 5% chance of developing lupus [107],... 

Houston and Houston and Stairs did clonal repeatability analyses to determine genetic control of tolerance in white pine with an ozone-sulfiir dioxide mixture and a 6-h exposure. Th used needle elongation and two injury estimates in assessing effects. The repeatability estimates indicated that tolerance to the pollutant mixture is under genetic control. The nature of the inheritance of tolerance is still not understood, but field selection of tolerant or susceptible individuals is possible. Demeritt et reported an evaluation system that used... 

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