Genetic interaction

Reanney DC, PC Gowland, JH Slater (1983) Genetic interactions among microbial commnnities. Symp Soc Gen Microbiol 34 379-421. 

Williams, P.A., Genetic interactions between mixed microbial populations, Philos. Trans. R. Soc. London, Ser. B, 297, 481-496, 1982. 

The word "genetotrophic" is rarely used so far, but it deserves new consideration in view of our increasing sophistication about genetics, nutrition and disease. It can include all degrees of nutrition-genetics interactions, from subtle to dramatic, and it seems far preferable to "nutrient dependencies," because we are all dependent on nutrients. 

Tab. 8.2. Identification of DUBs and DUB-binding partners through physical and genetic Interaction screens.

Vazquez, M., Moore, L., and Kennison, J.A. (1999) The trithorax group gene osa encodes an ARID-domain protein that genetically interacts with the brahma chromatin-remodeling factor to regulate transcription. Development 126, 733-742. 

Davie, J.K. and Kane, C.M. (2000) Genetic interactions between TFIIS and the Swi-Snf chromatinremodeling complex. Mol. Cell. Biol. 20, 5960-5973. 

Figure 2.3 All genetic interactions from the centromere to the first crossover are transmitted to offspring in gametes produced by a first division restitution mechanism such as parallel spindles.

All SM proteins interact with SNAREs, either directly or indirectly in complex with other proteins. Furthermore, strong genetic interactions have been documented between SM proteins and SNAREs. In some cases deletion of an SM protein is associated with a reduced expression level of its respective SNARE binding partner (Gallwitz and Jahn 2003). 

How does genetics interact with mutagenesis caused by environmental agents Figure 4-1 is an attempt to include all possibilities of specific sites or enzymes (that cure controlled by gene expression), compared with all nonspecific... 

There are basically three types of cytochrome P450 inducers (1) phenobarbital-like (the major class) (2) methylcholanthrene-like (which actually increases a P448 isozyme) and (3) anabolic steroids. The former two have been the most frequently studied. Research over the past 40-50 years indicates that their mechanism of action involves genetic interaction, possibly via derepression of a repressor gene, and the subsequent synthesis of mRNA for the specific enzyme proteins. Examples of phenobarbital-like enzyme inducers, the most common, are shown in Table 3.6. 

Schildkraut, J. M. (1998). Examining complex genetic interactions. In Gene Mapping in Complex Human Diseases, 379-410. John Wiley and Sons, New York. 

Vilclla E, Costas J, Sanjuan J, Guitart M, De Diego Y, et al. 2008. Association of schizophrenia with DTNBP1 but not with DAO, DAOA, NRG1 and RGS4 nor their genetic interaction. J Psychiatr Res 42 278-288. 

The Grid www.thebiogrid.org/ No restriction Protein and genetic interactions (fly, worm, yeast and human) Stark et al. (2006)... 

Shen, X., Ellis, R.E., Sakaki, K. and Kaufman, R.J. (2005b). Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans. PLoS Genet. J,e37. 

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