Mapping, genetic cell interaction

One of the most notable early successes of proteomics has been in providing a protein-protein interaction map for yeast cells. A major approach to building such maps has been to use the genetic approach of yeast two-hybrid mapping. Yeast two-hybrid experiments are based on the idea that some transcriptional activators require the activities of two proteins - one involved in DNA binding, and the other involved in transcriptional activation (Figure 9.22). 

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