Generalized profiles

The Ideal Fiber-Reactive Dye Profile. Eigure 3 shows the general profile for the apphcation of a reactive dye. In addition to showing the rate profile of fixation between dye and fiber, three other practical parameters (A—C) are noted. 

Some other types of macrocycle compounds have been synthesized using adamantane and its derivatives. Recently, a new class of cyclobisamides has been synthesized using adamantane derivatives, which shows the general profiles of amino acid (serine or cystine)-ether composites. They were shown to be efficient ion transporters (especially for Na+ ions) in the model membranes [159]. Another interesting family of compounds to which adamantane derivatives have been introduced in order to obtain cyclic frameworks is crown ethers [160]. The outstanding feature of these adamantane-bearing crown ethers (which are also called diamond crowns ) is that ot-amino acids can be incorporated into the adamantano-crown backbone [160]. This family of... 

Bucher, P., Karplus, K., Moeri, N., and Hofmann, K. (1996). A flexible motif search technique based on generalized profiles. Comput. Chem. 20, 3-23. 

Prosite is perhaps the best known of the domain databases (Hofmann et al., 1999). The Prosite database is a good source of high quality annotation for protein domain families. Prosite documentation includes a section on the functional meaning of a match to the entry and a list of example members of the family. Prosite documentation also includes literature references and cross links to other databases such as the PDB collection of protein structures (Bernstein et al., 1977). For each Prosite document, there is a Prosite pattern, profile, or both to detect the domain family. The profiles are the most sensitive detection method in Prosite. The Prosite profiles provide Zscores for matches allowing statistical evaluation of the match to a new protein. Profiles are now available for many of the common protein domains. Prosite profiles use the generalized profile software (Bucher et al., 1996). 

Over the years there have been considerable improvements in the available sequence analysis techniques. In particular the sequence profile method [3] with its more recent extension to generalized profiles [4], and various fJidden Mar-... 

Deuterium NMR measurements are performed for main-chain polymer liquid crystals having structures such as-[Ph-0-C0-Ph-O-(CH2)n-0-Ph-C0-O-Ph-0-(CH2)n-0lx- with n = 9 and 10. The general profiles of the spectra are found to be similar to those of the corresponding dimer. The results of the RIS analysis suggest that the spatial configurations of the spacer are nearly identical between the dimer and the polymer. 

The anisotropy of the interaction couples the translational and rotational states of collisional systems. This in turn couples the various dipole components. Instead of computing for each set of expansion parameters X XiSL one general profile for all rotational components associated with that set, one now has a much more complex computational task to compute the induced absorption continua. Moreover, the energy level diagrams as well as the spectra of van der Waals dimers are much more complex when the anisotropy of the interaction is accounted for. 

Figure 4. A generalized profile of Fe and S chemistry in sediment pore waters from an acidic lake. Numbered points are discussed in the text. (Reproduced with permission from reference 35. Copyright 1989 American Geochemical...

Figure 7.4 Generalized profiles of concentration and isotope ratio changes for dissolved sulfate and carbon species in anoxic marine sediments. Depth scale is arbitrary with depth units ranging from 10 1 to 102 m. (Reproduced from Claypool, G.E., Kvenvolden, K.A., Ann. Rev. Earth Planet Sci., 11, 299 (1983). With permission from Annual Reviews, Inc.)...

The general profile of the dioxygen oxidation of tetraaryldisilenes is shown in Eq. (63).7 Both in the solid state and in solution, the initial oxidation product of a tetraaryldisilene is the corresponding 1,2-disiladioxetane 145, whose intramolecular isomerization gives the thermodynamically more stable 1,3-disiladioxetane 146. All the steps of the oxidation occur intramolecularly and with the retention of stereochemistry around the Si-Si bond. While a small amount of disilaoxirane 147 is produced in the oxidation in low-temperature solution, 147 is converted to 146 smoothly in the presence of excess oxygen. 

Lew et al. 1997 Sloop et al. 1997). Studies performed in humans (reviewed in Eleopra et al. 2006) and in mice (Morbiato et al. 2007), show that BoNT/C has a general profile of action similar to that of BoNT/A. 

Disposal of hazardous waste is dangerous and expensive, even when the contents of the waste are identified. Fortunately, most chemical waste produced in a laboratory or work area is identifiable. When the contents of a reagent bottle, reaction flask, or gas cylinder are not identified, the process of disposal is more dangerous, expensive, and difficult. Without mitigating information, all unknown materials must be treated as if they were potentially lethal and hazardous. In all cases, chemical unknowns cannot be disposed of until a general profile of the unknown has been generated. Even then, the disposal cost is a premium. Additionally, there is a constant threat of personal injury or death to individuals who handle these potentially dangerous materials. No price tag can be attached to an avoidable personal injury. 

Next we come to the effect of surface tension on the dispersion relationship via the polar plot profile. This is shown in Fig. 7. Three features should be noted in the figure. First, the general profile of the polar plot does not... 

Harris, J.L. et al. 2000. Rapid and general profiling of protease specificity by using combinatorial fluorogenic substrate libaries. Proc. Natl. Acad. Sci. USA, 7754-7759. 

Define the goals of the separation. What degree of resolution needs to be achieved How many compounds need to be resolved It is crucial to have a clear statement of the problem to be solved. Is it necessary to obtain a quantitative separation of each compound present in a multicomponent mixture, or is there only one component of interest in the sample Is it necessary to achieve a general profile of the sample for routine screening purposes, or must there be a specific quantitative separation for collection and subsequent analysis by other methods ... 

Nonacidic drugs. COXIBs are associated with fewer gastrointestinal adverse effects, but otherwise the general profile of adverse reactions to NSAIDs applies. The possibility that COXIBs may be associated with increased risk of thrombotic cardiovascular events is the subject of pharmacovigilance studies. 

For biopharmaceuticals, quantitative monosaccharide profiling allows detection of residues indicative of undesired glycosylation (e. g. NeuGc) or the classes of glycans (for example, the presence of GalNAc indicates 0-glycosylation). For technical reasons, neutral and A-acetylat-ed residues are generally profiled separately from sialic acids. 

Overall, it is well understood that one method cannot cover the whole metabolome, so the current state-of-the-art demonstrates the need for the application of a number of analytical techniques such as reversed-phase liquid chromatography-mass spectrometry ((RP)LC-MS) untargeted as a general profiling tool, another RPLC-MS method to profile the lipids (on the C30 or C18 column), GC-MS to profile the content of volatiles, and one or two LC-MS or CE-MS methods (targeted and untargeted) to profile the polar metabolites (see Section 5.1). 

Bruker AXS, TOPAS V2.1 General Profile and Structure Analysis Software for Powder Diffraction Data.-User s Manual, Bruker AXS, Karlsruhe, Germany, 2003. 

TOPAS Academic by Alan Coelho, ISIS and TOPAS V3 General profile and structure analysis software for powder diffraction data. User s Manual, (2005) Bruker AXS, Karlsruhe,... 

Topas A fundamental parameters approach to X ray line profile fitting, R. W. Cheary and A. A. Coelho, J. Appl. Crystallogr., 1992, 25, 109 121, Fundamental Parameters Line Profile Fitting in Laboratory Diffractometers, R. W. Cheary, A. A. Coelho and J. P. Cline, J. Res. Natl. Inst. Stand. TechnoL, 2004, 109, 1 25, TOPAS Academic by Alan Coelho, ISIS and TOPAS V3 General profile and structure analysis software for powder diffraction data. User s Manual, (2005) Bruker AXS, Karlsruhe, Germany Fundamental parameters Rietveld with macro language... 

Figure 7.3 A generalized profile of a forested soil developed in a humid climate with a moderate temperature, showing a caliche (CaCOj) layer between the B and C horizons. From Fundamentals of Soil Science, 3d ed.

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