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Genes, antiviral

Antiviral Drugs. Figure 1 Basic steps of viral replication (A) binding, (B) entry, (C) genome replication, (D) gene expression, (E) assembly, (F) release. [Pg.196]

Interferon alfacon-1 (Inferax ), interferon alfa-2b (IntronA ), and interferon alfa-2a (Roferon -A) are applied in the treatment of chronic hepatitis B and C and some malignancies, especially hairy cell leukemia. IFN-a proteins induce the expression of antiviral, antiproliferative and immunomodulatory genes. [Pg.411]

Baltimore D (1971) Expression of animal virus genomes. Bacteriol Rev 35 235-241 Baltimore D (1988) Gene therapy. Intracellular immunization. Nature 335 395-396 Bauer DJ (1985) A history of the discovery and clinical application of antiviral drugs. Br Med Bull... [Pg.21]

Abstract In 2007, the world celebrated the 50th anniversary of the discovery of interferon (IFN) by Isaacs and Lindemnann. Subsequently, the IFN-a gene was cloned, fully sequenced and IFN-a was produced in recombinant form. Recombinant IFN-a is now used as the basis for treatment of chronic hepatitis C virus infection and can also be used to treat certain forms of chronic hepatitis B virus infections. IFNs have also been used in other viral infections, although with less success. The antiviral mechanisms of IFNs are reviewed in this chapter as well as the utility of IFNs in the treatment of persistent viral infections. [Pg.204]

Kleimnan et al. 2008). In addition, synthetic siRNAs are also subject to degradation in vivo by nuclease activity. Besides side effects and instability, the efficient and specific delivery of the RNAi indncers to the target cell still requires optimization. Here we snmmarize the cnrrent statns of nncleic acid-based antiviral therapentics. The focns will be on antiviral strategies nsing antisense and RNAi technology. Additionally, antiviral ribozymes and aptamers will be discussed briefly, with a focus on recent studies. Gene therapy approaches and delivery systems are the subject of Chapter 11 of this book. [Pg.246]

A different antiviral approach uses intracellular expression of unmodified antisense molecules corresponding to viral sequences. Such an intracellular immunization approach may require a gene therapy protocol to deliver the antiviral transgene. In a phase I chnical trial, Levine et at. used intraceUularly expressed... [Pg.247]

Chronic Viral Infections as Targets for Antiviral Gene Therapy.268... [Pg.265]

Clinical Trials Involving T Cell Gene Transfer of Antiviral Genes.279... [Pg.265]

Antiviral Gene Products with a Bystander Effect.283... [Pg.265]

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See also in sourсe #XX -- [ Pg.272 , Pg.273 , Pg.279 , Pg.287 ]



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