Therapeutic angiogenesis gene therapy

Two approaches have generally been used to achieve therapeutic angiogenesis protein therapy and gene transfer which are briefly discussed next. 

The efficacy of gene transfer approaches to therapeutic angiogenesis is now being tested in clinical trials. Controlled phase II trials are providing positive but not definitive results. Gene therapy appears to be safe based on these data. Hard clinical endpoints, such as mortality, myocardial infarction, and the need for revascularization are lacking, as is long-term follow-up. 

Adenovirus-based Gene Therapy Therapeutic Angiogenesis with Adenovirus 5 Fibroblast Growth Factor-4 (Ad5FGF-4) in Patients with Chronic Myocardial Ischemia... 

This chapter will review the rationale for the use of Ad5FGF-4 for therapeutic angiogenesis, the composition of the gene therapy product, the manufacturing and analysis of the product, preclinical animal data and initial clinical results in the largest population of patients to date who have undergone intracoronary administration of gene therapy for myocardial ischemia. 

Gene Therapy and Other Biological Therapeutic Approaches for Anti-angiogenesis... 

Khan, T.A., Sellke, E.W., Laham, R.J. Gene therapy progress and prospects Therapeutic angiogenesis for limb and myocardial ischemia. Gene Ther. 10, 285-291 (2003)... 

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