Gatifloxacin

Molecular formula C19H22FN3O4 Molecular weight 375.39 CAS Registry No 112811 -59-3 Merck Index 13,4388 

Sample preparation Serum. Mix 200 jaL serum with 200 (xL 500 xg/mL IS in MeCN 100 mM phosphoric acid 90 10 and 400 xL MeCN, centrifuge. Mix 200 xL of the supernatant with 800 (xL PIC A solution, inject a 20 (xL aliquot. Urine. Dilute 10 (xL urine with 990 jxL PIC A solution, inject a 5 (xL aliquot. (PIC A solution was 10 mM tetrabutylammonium phosphate (Waters PIC A) adjusted to pH 3.48.) 

Guard column 30 x 4 30-40 xm Perisorb RP-18 Column 125 x 4 5 M-m Nucleosil-100 5C18 

Mobile phase MeCN 10 mM tetrabutylammonium phosphate (Waters PIC A) 17 83, adjusted to pH 3.48 with ca. 1.3 mL concentrated phosphoric acid. 

Hartwig, H. Lode, H. Determination of gatifloxacin in human serum and urine by HPLC, Chromatographia, 2000, 52, S105 S107. 

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The fluoroquinolones include ciprofloxacin (Cipro), enoxacin (Penetrex), gatifloxacin (Tequin), lome-floxacin (Maxaquin), moxifloxacin (Avelox), ofloxacin (Floxin), and sparfloxacin (Zagain). 

Concurrent use of the fluoroquinolones with theophylline causes an increase in serum theophylline levels. When used concurrently with cimetidine, the cimetidine may interfere with the elimination of the fluoroquinolones. Use of the fluoroquinolones with an oral anticoagulant may cause an increase in the effects of the oral coagulant. Administration of the fluoroquinolones with antacids, iron salts, or zinc will decrease absorption of the fluoroquinolones. There is a risk of seizures if fluoroquinolones are given with the NSAIDs. There is a risk of severe cardiac arrhythmias when the fluoroquinolones gatifloxacin and moxifloxacin are administered with drains that increase the QT interval (eg, quini-dine, procainamide, amiodarone, and sotalol). 

Ciprofloxacin, gatifloxacin, and ofloxacin are the only fluoroquinolones given intravenously (IV). None of the fluoroquinolones are given intramuscularly (IM). 

The primary health care provider prescribed 400 mg gatifloxacin PO daily for 7 days. The drug is available in 200-mg tablets. How many tablets would die nurse administer each day ... 

P-lactam antimicrobials, gatifloxacin, indinavir, isoniazid, levofloxacin, nitrofurantoin, ribavirin, rifabutin, rifampin, silver sulfadiazine, streptomycin, sulfonamide antimicrobials, and tetracyclines... 

Adenosine 3-Blockers Amiodarone Carbamazepine Chloroquine Digoxin Diltiazem Gatifloxacin... 

Because an infection slows the healing of a corneal abrasion, prophylactic antibiotics are often used. Studies on the efficacy of this are mixed. Discontinue the use of contact lenses until the abrasion is healed and the antibiotic course complete. In contact lens wearers, choose an antibiotic that covers Pseudomonas aeruginosa, like gentamicin ointment or solution or a fluoroquinolone.3 Antibiotic resistance is an increasing problem. Resistance occurs primarily with older antibiotics, but has been reported for fluoroquinolones as well. Two newer fluoroquinolones, gatifloxacin and moxifloxacin, do not yet have reports of resistance. These agents are more expensive.6... 

Gatifloxacin 400 mg once daily Not available Common fluoroquinolone side effects are nausea,... 

Levofloxacin Moxifloxacin Gatifloxacin Adults 500-1 000 mg daily Children See footnote Adults 400 mg daily Children See footnote Adults 400 mg daily Children See footnote Gastrointestinal disturbance, neurologic effects, cutaneous reactions No specific monitoring recommended... 

The long-term (more than several weeks) use of gatifloxacin in children and adolescents has not been approved because of concerns about effects on... 

Azalides azithromycin Azoles fluconazole, itraconazole, ketoconazole, and voriconazole Macrolides erythromycin, clarithromycin Protease inhibitors amprenavir, indinavir, lopinavir/ritonavir, nelfinavir, ritonavir, and saquinavir Quinolones ciprofloxacin, gatifloxacin, levofloxacin, moxifloxacin. 

See section on treatment of bacterial pneumonia. Macrolide/azalide erythromycin, clarithromycin, azithromycin. cTetracydine tetracycline hydrochloride, doxycydine. Cephalosporin cefuroxime, ceftriaxone, cefotaxime. eCarbapenem imipenem-cilastatin, meropenem. Fluoroquinolone ciprofloxacin, gatifloxacin, or levofloxacin. 

Either (a) aztreonam plus levofloxacin or (b) aztreonam plus moxifloxacin or gatifloxacin, with or without an aminoglycoside... 

Immediate-lype hypersensitivity Clarithromycin or azithromycin or trimetiioprim-sulfamelhoxazole or doxycycline or respiratory fluoroquinolone (levofloxacin or gatifloxacin). 

Spectinomycin 2 g IM once, or ceftizoxime 500 mg IM once, or cefotaxime 500 mg IM once, or cefoxitin 2 g IM once with probenecid I g po once, or gatifloxacin 400 mg po once, or lomefloxacin 400 mg po once, or norfloxacin 800 mg po once plus... 

Gatifloxacin Tablets (400 mg) aqueous solution (200 mg/20 Adults 400 mg daily There are no data to support There are no data to sup- There are no data to support... 

This class of compounds comprises a series of synthetic agents patterned after nalidixic acid, a naphthyridine derivative introduced in 1963 for the treatment of urinary tract infections. Isosteric heterocyclic groupings in this category include the quinolones (e.g., norfloxacin, ciprofloxacin, lome-floxacin, gatifloxacin, sparfloxacin, moxifloxacin, and ofloxacin), the naph-thyridones (e.g., nalidixic acid, enoxacin, and trovafloxacin), and the cin-nolones (e.g., cinnoxacin) [2] (Fig. 1). 

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