Gas chromatography/electron-capture negative-ion chemical ionization

Longo, M. and Cavallaro, A., Determination of aromatic amines at trace levels by derivatization with heptaflourobutyric anhydride and gas chromatography-electron capture negative-ion chemical ionization mass spectrometry, J. Chromatogr. A, 753, 91-100, 1996. 

Gas chromatography/electron-capture negative-ion chemical ionization mass spectrometry (GC/ECNICIMS) has become widely used for quantification of... 

The most suitable and effective method to date that is capable of analyzing several neurosteroids simultaneously is gas chromatography/electron capture-negative chemical ionization/mass spectrometry (GC/EC-NCI/MS) with selected ion monitoring (SIM). This technique allows a focus on a few specific ions bearing structural information. 

ECD = electron capture detector GC = gas chromatography HPLC = high-performance liquid chromatography MC = microcoulometric detector MS = mass spectrometry NICI = negative ion chemical ionization RSD = relative standard deviation SPE = solid phase extraction... 

Gas chromatography-mass spectrometry of nine nltroaromatic compounds was carried out in order to evaluate its potential as an analytical method for the determination of TNT and possible related impurities in environmental samples such as water and soil [8]. Nitrobenzene, the three mononitrotoluenes (MNTs), 1,3-DNB, 2,4-DNT, 2,6-DNT, and TNB were analyzed in addition to TNT. The MS ionization techniques included El, positive-ion chemical ionization (Cl) and negative-ion Cl (NCI), all recorded in both full-scan and selective ion monitoring (SIM) modes. They were compared with GC analysis with electron capture detection (ECD). The comparison included sensitivity (detection limits), linear response range, and precision. The GC ECD was recommended for those analyses where there was no uncertainty in the identity of the analytes. 

---