Gamma-aminobutyric acid release

Hada J, Kaku T, Jiang MH, Morimoto K, Hayashi Y. 2003. Inhibition of high K -evoked gamma-aminobutyric acid release by sodium nitroprusside in rat hippocampus. Eur J Pharmacol 467(1-3) 119-123. [Pg.246]

Wolf, R. and Tscherne, U. (1994) Valproate effect on gamma-aminobutyric acid release in pars reticulata of substantia nigra combination of push-pull perfusion and fluorescence histochemistry. Epilepsia 35 226-233. [Pg.327]

Pereira EFR, Reinhardt-Maehcke S, Schrattenholz A, et al Identification and functional characterization of a new agonist site on nicotinic acetylchohne receptors of cultured hippocampal neurons. J Pharmacol Exp Ther 265 1474-1491, 1993 Perez de la Mora N, Hemandez-Gomez AM, et al Cholecystokinin-8 increases K -evoked [ H] gamma-aminobutyric acid release in shces from various brain areas. Eur J Pharmacol 250 423-430, 1993... [Pg.717]

Crespi D, Gobbi M, Mennini T (1997) 5-HT3 serotonin hetero-receptors inhibit [3H]acetylcholine release in rat cortical synaptosomes. Pharmacological Res 35 351 Cunha RA, Ribeiro JA (2000) ATP as a presynaptic modulator. Life Sci 68 119-37 De Waard M, Hering J, Weiss N, Feltz A (2005) How do G proteins directly control neuronal Ca2+ channel function Trends Pharmacol Sci 26 427-36 Cunha RA, Constantino MD, Ribeiro JA (1997) Inhibition of [3H][gamma]-aminobutyric acid release by kainate receptor activation in rat hippocampal synaptosomes. Eur J Pharmacol 323 167 Delaney AJ, Jahr CE (2002) Kainate receptors differentially regulate release at two parallel fiber synapses. Neuron 36 475-82... [Pg.517]

Tian N, Petersen C, Kash S, Baekkeskov S, Copenhagen D, Nicoll R (1999) The role of the synthetic enzyme GAD65 in the control of neuronal gamma-aminobutyric acid release. Proc Natl Acad Sci USA 96 12911-12916. [Pg.111]

Cotman CW, Haycock JW, White WF. 1976. Stimulus-secretion coupling processes in brain Analysis of noradrenaline and gamma-aminobutyric acid release. J Physiol 254 475-505. [Pg.331]

Alkondon, M., Pereira, E.F.R., Barbosa, C.T.P., and Albuquerque, E.X., Neuronal nicotinic acetylchohne receptor activation modulates gamma-aminobutyric acid release from CAl neurons of rat hippocampal shces, J. Pharmacol. Exp. Then, 283, 1396, 1997. [Pg.37]

Pin JP, Yasumoto T, Bockaert J (1988) Maitotoxin evoked Gamma-aminobutyric acid release is due not only to the opening of Calcium channels. J Neurochem 50(4) 1227-1231. [Pg.91]

Reid, M. Herrera-Marschitz, M. Hokfelt, T. Terenius, L. and Ungerstedt, U. Differential modulation of striatal dopamine release by intranigral injection of gamma-aminobutyric acid (GABA), dynorphin A and substance P. Eur J Pharmacol 147 411-420, 1988. [Pg.268]

Yamamoto, B.K., Nash, J.F., and Gudelsky, G.A., Modulation of methylenedioxymethamphetamine-induced striatal dopamine release by the interaction between serotonin and gamma-aminobutyric acid in the substantia nigra, J. Pharmacol. Exp. Ther. 273(3), 1063-1070, 1995. [Pg.136]

Figure 1.2 Serotonin is one of the brain s neurotransmitters. This image depicts serotonin transmission between neurons and the drug Ecstasy s effects on that transmission. Serotonin is normally removed from the synapse shortly after being released. Ecstasy blocks this mechanism, increasing the amount of serotonin in the synapse. This causes the postsynaptic neuron to be overstimulated by serotonin. Serotonin is one of many neurotransmitters that nerve cells can secrete. Other common neurotransmitters include dopamine, glutamate, gamma aminobutyric acid (GABA), noradrenaline, and endorphins.

So far attention has concentrated on the effects of lithium on excitatory transmitters. There is evidence that the drug can also facilitate inhibitory transmission, an effect that has been attributed to a desensitization of the pres)maptic gamma-aminobutyric acid (GABA) receptors, which results in an increase in the release of this inhibitory transmitter. The increased conversion of glutamate to GABA may also contribute to this process. Thus it would appear that lithium has a varied and complex action on central neurotransmission, the net result being a diminution in the activity of excitatory transmitters and an increase in GABAergic function. [Pg.204]

In simple terms, messages travel along neurons (nerve cells) in the form of an electrical current that moves from one end of the neuron to its opposite end. The electric current is produced by a flow of sodium ions (Na ") and potassium ions (K ) across the nerve membrane, as shown in the diagram on page 11. When the electrical current reaches the end of the neuron, it causes the release of a chemical known as a neurotransmitter. Some examples of neurotransmitters are acetylcholine, serotonin, dopamine, GABA (gamma-aminobutyric acid), and norepinephrine. [Pg.10]

Levy, E, Kendrick, K.M., Goode, J.A., Guevara-Guzman, R., and Keverne, E.B. (1995) Oxytocin and vasopressin release in the olfactory bulb of parturient ewes changes with maternal experience and effects on acetylcholine, gamma-aminobutyric acid, glutamate and noradrenaline release. Brain Res 669 197-206. [Pg.208]

Beani L, Tanganelh S, Antonelh T, et al Noradrenergic modulation of cortical acetylcholine release is both direct and gamma-aminobutyric acid-mediated. J Pharmacol Exp Ther 236 230-236, 1986 Beatty WW, Butters N, Janowsky D Patterns of memory failure after scopolamine treatment implications for the chohnergic hypothesis of dementia. Behavioral and Neural Biology 45 196-211, 1986... [Pg.594]

SNA does not affect the concentrations of histamine and glutamic add, but It decreases the activity of glutamic acid decarboxylase and reduces the concentrations of gamma-aminobutyric acid (GABA) In rat brain. 5 GABA release Is Inhibited by acute administration, but not by chronic treatment. 5 SNA Increases serum creatinine phosphoklnase content In stressed rats. Recently, SNA was found to decrease methionine-enkephalin content In the medulla oblongata and mldbraln In the mouse, whereas other areas remained unaffected.48... [Pg.63]

It is beta-4 (chlorophenyl)-gamma aminobutyric acid. It is a powerful neuronal depressant. It reduces the release of excitatory transmitter and is antinociceptive in animal studies. It inhibits monosynaptic and polysynaptic reflex transmission at spinal level, probably by stimulating the GABAg... [Pg.113]

An interaction between G. biloba administered as 80 mg leaf extract twice a day and low-dose trazodone (20 mg twice daily) was suspected in a patient with Alzheimer s disease, who took the two products together. It is postulated that a pharmacodynamic (increased gamma-aminobutyric acid-ergic activity) and pharmacokinetic mechanisms [increased metabolism of trazodone to w-chlorophenylpiperazine (w -CPP), which acts on the benzodiazepine-binding sites and releases gamma-aminobutyric acid] contribute to the observed effect (32). Table 2 provides a list of reported pharmacodynamic and pharmacokinetic interactions involving ginkgo. [Pg.113]

Stoof JC, De Boer T, Sminia P, Mulder AH (1982) Stimulation of D2-dopamine receptors in rat neostriatum inhibits the release of acetylcholine and dopamine but does not affect the release of gamma-aminobutyric acid, glutamate or serotonin. Eur J Pharmacol 84 211-14 Subramony JA (2006) Apomorphine in dopaminergic therapy. Mol Pharmaceut 3 380-5 Takeshita Y, Watanabe T, Sakata T, Munakata M, Ishibashi H, Akaike N (1998) Histamine modulates high-voltage-activated calcium channels in neurons dissociated from the rat tuberomam-millary nucleus. Neuroscience 87 797-805... [Pg.336]

Ronde P, Nichols RA (1998) High calcium permeability of serotonin 5-HT3 receptors on presynaptic nerve terminals from rat striatum. J Neurochem 70 1094-1103 Rosenstein RE, Chuluyan HE, Cardinali DP (1990) Presynaptic effects of gamma-aminobutyric acid on norepinephrine release and uptake in rat pineal gland. J Neural Transm 82 131—40 Rousseau SJ, Jones IW, Pullar IA, Wonnacott S (2005) Presynaptic [alpha]7 and non-[alpha]7 nicotinic acetylcholine receptors modulate [3H]d-aspartate release from rat frontal cortex in vitro. Neuropharmacology 49 59... [Pg.524]

Globus M. Y., Busto R., Dietrich W. D., Martinez E., Valdes I., and Ginsberg M. D. (1988) Effect of ischemia on the in vivo release of striatal dopamine, glutamate, and gamma-aminobutyric acid studied by intracerebral microdialysis. /. Neurochem. 51,1455-1464. [Pg.36]

Taylor J, Docherty M, Gordon-Weeks PR (1990) GABAergic growth cones release of endogenous gamma-aminobutyric acid precedes the expression of synaptic vesicle antigens. J Neurochem 54 1689-1699. [Pg.195]

Horvath TL, Naftolin F, Leranth C (1993) Luteinizing hormone-releasing hormone and gamma-aminobutyric acid neurons in the medial preoptic area are synaptic targets of dopamine axons originating in anterior periventricular areas. J Neuroendocrinol 5 71-79. [Pg.507]

Kalia V, Fenske C, Hole DR, Wilson CA (1999) Effect of gonadal steroids and gamma-aminobutyric acid on LH release and dopamine expression and activity in the zona incerta in rats. J Reprod Fertil 777 189-197. [Pg.508]

Wilson CA, James MD, Leigh AJ (1990) Role of gamma-aminobutyric acid in the zona incerta in the control of luteinizing hormone release and ovulation. Neuroendocrinology 52 354-360. [Pg.522]

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