Regulation of GH Release

A fall in blood glucose level stimulates GH release, whereas a rise inhibits GH release. GH release also occurs in response to certain amino acids, the most potent being L-arginine, but with a latency period of about 30 minutes. Circulating hormones exert their effects at the level of the hypothalamus or the pituitary. GH influences its own secretion by way of IGFs that exert a negative feedback effect at the median eminence. However, whether this feedback involves a decrease in GHRH, an increase in somatostatin, or both is not known. Other hormones promote the synthesis and release of GH at the level of the anterior pituitary. 

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