Aspartate release

In other experiments, we found that PCP also inhibited ACh release induced by the amino acid transmitter candidates, L-glutamate and L-aspartate. Release of ACh by these amino acids had a similar Mg++sensitivity to that induced by NMDA, suggesting an action of these amino acids on the N-type receptor. No inhibition of release by PCP could be seen in the presence of Mg++. 

Rousseau SJ, Jones IW, Pullar lA, Wonnacott S (2005) Presynaptic alpha7 and non-alpha7 nicotinic acetylcholine receptors modulate [ H]d-aspartate release from rat frontal cortex in vitro. Neuropharmacology 49 59-72... 

Phillis J. W. and O Regan M. H. (1996). Mechanisms of glutamate and aspartate release in the ischemic rat cerebral cortex. Brain Res. 730 150-164. 

Ronde P, Nichols RA (1998) High calcium permeability of serotonin 5-HT3 receptors on presynaptic nerve terminals from rat striatum. J Neurochem 70 1094-1103 Rosenstein RE, Chuluyan HE, Cardinali DP (1990) Presynaptic effects of gamma-aminobutyric acid on norepinephrine release and uptake in rat pineal gland. J Neural Transm 82 131—40 Rousseau SJ, Jones IW, Pullar IA, Wonnacott S (2005) Presynaptic [alpha]7 and non-[alpha]7 nicotinic acetylcholine receptors modulate [3H]d-aspartate release from rat frontal cortex in vitro. Neuropharmacology 49 59... 

Burke SP, Nadler JV. 1989. Effects of glucose deftciency on glutamate/aspartate release and excitatory synaptic responses in the hippocampal CAI area in vitro. Brain Res 500 333-342. 

IS ASPARTATE RELEASED BY EXOCYTOSIS FROM NERVE ENDINGS ... 

Burke SP, Nadler JV (1988) Regulation of glutamate and aspartate release from slices of the hippocampal CAI area effects of adenosine and baclofen. J Neurochem 57 1541-1551. 

Flavin HJ, Seyfried TN (1994) Enhanced aspartate release related to epilepsy in (EL) mice. J Neurochem 63 592-595. 

Maura G, Carbone R, Raiteri M (1989) Aspartate-releasing nerve terminals in rat striatum possess D-2 dopamine receptors mediating inhibition of release. J Pharmacol Exp Ther25t 142-1146. 

Nadler JV, Martin D, Bustos GA, Burke SP, Bowe MA (1990) Regulation of glutamate and aspartate release from the Schaffer collaterals and other projections of CA3 hippocampal pyramidal cells. Prog Brain Res 8i l 15-130. 

Peterson CL, Thompson MA, Martin D, Nadler JV (1995) Modulation of glutamate and aspartate release from slices of hippocampal area CA1 by inhibitors of arachidonic acid metabolism. J Neurochem 64 1152-1160. 

Zhou M, Peterson CL, Lu YB, Nadler JV (1995) Release of glutamate and aspartate from CAl synaptosomes selective modulation of aspartate release by ionotropic glutamate receptor ligands. J Neurochem 64 1556-1566. 

Pharmacology and Mechanism of Action. Lamotrigine blocks voltage-sensitive sodium channels, modulates or decreases glutamate and aspartate release, and has antikindling properties (see Table 68-10)." 2 " ... 

Ding O, Vaynman S, Akhavan M, Ying Z, Gomez-Pinilla F (2006) InsuUn-like growth factor I interfaces with brain-derived neurotrophic factor-mediated synaptic plastidty to modulate aspects of exercise-induced cognitive function. Neuroscience 140 823-833 Doble A, Hubert JP, Blanchard JC (1992) Pertussis toxin pretreatment abolishes the inhibitory effect of riluzole and carbachol on D-[3H]aspartate release from cultured cerebellar gianule cells. Neurosci Lett 140 251-254... 

The analysis of a large number of neurotransmitters and their metabolites as TMS denvatives has been excellently reviewed by Abramson and coworkers (1974). The electron impact (El) spectra of all the TMS-amino acids have also been reviewed (Iwase et al., 1979) In neurochemical studies, a number of workers have used the TMS derivatization procedure to measure tissue GABA (Cattabeni et al., 1976, 1977 Holdiness et al., 1981 Haseyawa et al, 1981). TMS-glutamate has been found to be extremely valuable for GC-MS analysis in the Cl mode with ammonia as the reagent gas (Dessort et al, 1982). An example of the use of TMS derivatives to monitor glutamate and aspartate release in brain dialysis experiments is presented in Fig. 4. 

Young, A. M. J., and Bradford, H. F., 1991, A-methyl-o-aspartate releases excitatory amino acids in rat corpus striatum in vivo, J. Neurochem. 56 1677-1683. 

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