G-aminobutyric acid

See also g-Aminobutyric acid.) PYRROLE AND PYRROLE DERIVATIVES] (Vol 20)... 

Finn DA, Gee KW The influence of estrous cycle on neurosteroid potency at the g-aminobutyric acid A receptor complex. J Pharmacol Exp Ther 265 1374-1379, 1993... 

Kokate TG, Svensson BE, Rogawski MA Anticonvulsant activity of neurosteroids correlation with g-aminobutyric acid-evoked chloride current potentiation. J Pharmacol Exp Ther 270 1223-1229, 1994... 

Lan NC, Gee KW, Bolger MB, et al Differential responses to expressed recombinant human g-aminobutyric acid A receptors to neurosteroids. J Neurochem 57 1818-1821, 1991... 

Purdy RH, Morrow AL, Moore PH, et al Stress-induced elevations of g-aminobutyric acid type A receptor active steroids in the rat brain. Proc Natl Acad Sci USA 88 4553-4557, 1991... 

Saridaki E, Carter DA, lightman SL g-Aminobutyric acid regulation of neurohypophysial hormone secretion in male and female rats. J Endocrinol 121 343-349, 1989... 

Mohler IJ, Evans SJ. g-Aminobutyric acid (GABA), receptors and their association with benzodiazepine recognition sites. In Meltzer HY, ed. Psychopharmacology the third generation of progress. New York Raven Press, 1987 265-272. 

Other neurotransmitter systems have also been implicated in depression, including g-aminobutyric acid (GABA), the opioids, and, in particular, dopamine. 

In 1977, BZD receptors were identified when it became possible to map their location within the CNS. They were found to be intimately related to g-aminobutyric acid (GABA), the most prevalent inhibitory neurotransmitter system in the brain, which acts in the following locations ... 

Strong evidence indicates at least a familial pattern and perhaps a hereditary basis for some types of alcoholism ( 393). More recent data show that genotype accounts for approximately 33% of the overall variance in liability ( 394). In addition, specific neurocircuitry and neurochemical systems appear to be important in the etiology of alcoholism (395). Thus, positive reinforcement may be mediated by activation of g-aminobutyric acid (GABA) receptors, release of opioid peptides and dopamine, inhibition of glutamate receptors, and interactions with the 5-HT system. Furthermore, neurobehavioral effects of alcohol and their association with these various neurotransmitters serve as potential targets for novel drug therapies. 

FIGURE 65.4 GABA-benzodiazepine-chloride channel complex. GABA = g-aminobutyric acid. 

B) percent b-alanine plus g-aminobutyric acid (%(BALA+GABA)) versus the vanillic acid vanillin ratio (Ad/Al)v. Symbols are as in Fig. 15.13. 

C20H41N02 g-aminobutyric acid cetyl ester 34562-99-7 667.15 60.154 2 32715 C21H19N302 N-benzoyloxy-N-ethyl-4-aminoazobenzene 55398-24-8 570.25 50.673 1,2... 

Wermuth, C.G., Bourguignon, J.-J., Schlewer. G., Gies, J.P., Schoenfelder, A., et al. (1987) Synthesis and structure-activity relationships of a series of aminopyridazine derivatives of g-aminobutyric acid acting as selective GABAa antagonists. J. Med. Chem. 30 239-249. 

Maneuf, Y.P, Nash, J.E., Crossman, A.R. and Brotchie, J.M. (1996) Activation of the cannabinoid receptor by A -tetrahydrocannabinol reduces g aminobutyric acid uptake in the globus pallidus, Eur J Pharmacol, 308 161-164. 

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