Y-aminobutyric acid type B

K, Alder, F, Smith, A, McKernan, R, Metters, K, O Neill, GP, Facaille, JC and Hebert TE (2001) y-Aminobutyric acid type B receptors with specific heterodimer composition and postsynaptic actions in hippocampal neurons are targets of anticonvulsant gabapentin action. Mol. Pharmacol. 59 144-152. 

The mGluRs belong to family C of the GPCR superfamily, which also includes a calcium-sensing receptor (CaR), two y-aminobutyric acid type B (GABAb) receptors,... 

Class 3 Calcitonin gene-related peptide Metabotropic glutamate Ca +-sensing reagents y-aminobutyric acid type B... 

Benke D, Honer M, Michel C, Bettler B, MohlerH. 1999. y-Aminobutyric acid type B receptor splice variant proteins GBRla and GBRlb are both associated with GBR2 in situ and display differential regional and subcellular distribution. J. Biol. Chem. 274 27323-30... 

Bonnert, TP, McKernan, RM, Farrar, S, le Bourdelles, B, Heavens, RP, Smith, DW, Hewson, L, Rigby, MR, Sirinathsinghji, DJ, Brown, N, Wafford, KA and Whiting, PJ (1999) B, a novel y-aminobutyric acid type A receptor subunit. Proc. Natl. Acad. Sci. USA 96 9891-9896. 

Connolly, C. N., Krishek, B. J., McDonald, B. J., Smart, T. G., and Moss, S. J. (1996) Assembly and cell surface expression of heteromeric and homomeric y-aminobutyric acid type A receptors. J. Biol. Chem. 271, 89-96. 

Ebert, B., Thompson, S. A., Suonatsou, K McKeman, R., Krogsgaard-Larsen, R, and Waf-ford, K. A. (1997) Differences in agonist/antagonist binding affinity and receptor transduction using recombinant human y-aminobutyric acid type A receptors. Mol. Pharmacol. 52, 1150-1156. 

Strohle A, Romeo E, di Michele F, Pasini A, Hermann B (2003) Induced panic attacks shift y-aminobutyric acid type A receptor modulatory neuroactive steroid composition in patients with panic disorder. Arch Gen Psychiatry 60 161-168... 

Fig. 5.12 (a) Synaptic types along dendritic spines of M/T and GC units uni-, and bi-directional junctions, (b) Transmitter systems at a reciprocal synapse, Mitral-Granule cell junction. [Glu, glutamate (R, receptor) GABA, y-aminobutyric acid (R, receptor) E, intracellular effector and aAR, alpha-adrenergic receptor.]. (From Hayashi et al., 1993.)... 

An interesting example of biocatalysis and chemical catalysis is the synthesis of a derivative of y-aminobutyric acid (GABA) that is an inhibitor for the treatment of neuropathic pain and epilepsy (Scheme 10.4). The key intermediate is a racemic mixture of cis- and trons-diastereoisomer esters obtained by a hydrogenation following a Horner-Emmons reaction. The enzymatic hydrolysis of both diaste-reoisomers, catalyzed by Candida antarctica lipase type B (CALB), yields the corresponding acid intermediate of the GABA derivative. It is of note that both cis- and trans-diastereoisomers of the desired enantiomer of the acid intermediate can be converted into the final product in the downstream chemistry [10]. 

McMahon HT, Foran P, Dolly JO et at. (1992) Tetanus toxin and botulinum toxins type A and B inhibit glutamate, y-aminobutyric acid, aspartate, and met-enkephalin release from synaptosomes. J. Biol. Chem. 276 21338-21343. 

Ion flux (a) Influx of Na during depolarization event (b) Influx of Ca " (c) Efflux ofK + (d) Influx ofCr Nicotinic Muscarinic (type 1), -adrenergic, Hi histaminergic Cardiac muscarinic y-Aminobutyric acid ergic, glycine... 

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