Fusarium moniliforme fumonisins

International Agency for Research on Cancer (lARC) (1993). Toxins derived from Fusarium moniliforme Fumonisins Bi and Bz and Fusarin C. In "lARC Monographs on the Evaluation of the Carcinogenic Risks to Humans Some Naturally Occurring Substances Food Items and Constituents, Heterocyclic Aromaotic Amines and Mycotoxins," vol. 56, pp. 445 66. International Agency for Research on Cancer, Lyon, France. 

Fumonisin B, (see Toxins derived from Fusarium moniliforme) Fumonisin Bj To dns derived from Fusarium moniliforme Furan... 

Fusarium moniliforme sya verticillioides causes the so-called ear rot disease in maize and produces fumonisin B, (IB,), one of the most frequently detected mycotoxins in the food supply chain worldwide (Steyn, 1995). FBi can inhibit lipid formation, particularly in the liver. Fumonisins have been detected and investigated only relatively recently. Several structurally related forms of fumonisins (FBS) have been associated with human cancer (e.g. FB with oesophageal cancer) as well as with a host of problems in livestock fed with FB -contaminated feed (D Mello, 2003 Benbrook, 2005). 

Velluti A, Marin S, Bettucci L, Ramos AJ, Sanchis V (2000) The effect of fungal competition on colonization of maize grain by Fusarium moniliforme, F. proliferatum and F. graminearum and on fumonisin B and zearalenone formation. Int J Food Microbiol 59 59-66... 

Fumonisins, first isolated from corn cultures of Fusarium moniliforme, are also produced by several other Fusarium species (F. anthophilum, F. proliferatum, F. dlamini, F. napiforme, and F. nygamai) (68). From the seven structurally related fumonisin analogs, only fuminisins B, (FB,), B2 (FB2), and B3 (FB3) are naturally occurring in com (69,70). The first two invariably occur together and have been extensively studied. Molecular structures of fumonisins are shown in Fig. 8. 

PF Ross, PE Nelson, JL Richard, GD Osweiler, LG Rice, RD Plattner, TM Wilson. Production of fumonisins by Fusarium moniliforme and Fusarium proliferatum isolates associated with equine leukoencephalomalacia and a pulmonary oedema syndrome in swine. Appl Env Microbiol 56 3225, 1990. 

RD Plattner. Detection of fumonisins produced in Fusarium moniliforme cultures by HPLC with electrospray MS and evaporative light scattering detectors. Nat Toxins 3 294-298, 1995. 

RD Plattner, D Weisleder, SM Poling. Analytical determination of fumonisins and other metabolites produced by Fusarium moniliforme and related species in com. In LS Jackson, JW DeVries, LB Bullerman, eds. Fumonisins in Food. New York Plenum Press, 1996, pp 57-64. 

Gelderblom, W. C., Jaskiewicz, K., Marasas, W. F., Thiel, P. G., Horak, R. M., Vleggaar, R., and Kriek, N. P. (1988). Fumonisins - Novel mycotoxins with cancer-promoting activity produced by Fusarium moniliforme. Appl. Environ. Microbiol. 54(7), 1806-1811. 

Gross, S. M., Reddy, R. V., Rottinghaus, G. E., Johnson, G., and Reddy, C. S. (1994). Developmental effects of fumonisin Bl-containing Fusarium moniliforme culture extract in CD1 mice. Mycopathologia 128(2), 111-118. 

Powell, D. C., Bursian, S. J., Bush, C. R., Render, J. A., Rottinghaus, G. E., and Aulerich, R. J. (1996). Effects of dietary exposure to fumonisins from Fusarium moniliforme culture material (M-1325) on the reproductive performance of female mink. Arch. Environ. Contam. Toxicol. 31(2), 286-292. 

Voss, K. A., Plattner, R. D., Riley, R. T., Meredith, F. I., and Norred, W. P. (1998). In vivo effects of fumonisin Bl-producing and fumonisin Bl-nonproducing Fusarium moniliforme isolates are similar Fumonisins B2 and B3 cause hepato- and nephrotoxicity in rats. Myco-pathologia 141(1), 45-58. 

Wang, E., Ross, P. F., Wilson, T. M., Riley, R. T., and Merrill, A. H., Jr. (1992). Increases in serum sphingosine and sphinganine and decreases in complex sphingolipids in ponies given feed containing fumonisins, mycotoxins produced by Fusarium moniliforme. /. Nutr. 122(8), 1706-17016. 

Fumonisin Bl] Fusarium moniliforme (fungal Apoptotic (INF pathway,... 

Norred WP Fumonisins - Mycotoxins produced by Fusarium moniliforme. J Toxicol Environ Health 1993 38 309-328. 

Desjardins AE, Plattner RD, Nelson TC, Leslie J Genetic analysis of fumonisin production and vimlence of Gibberella fujikuroi mating population A Fusarium moniliforme) on maize Zea mays) seedlings. Appl Environ Microbiol 1995 61 79-86. 

Fumonisin B, (Fig. 9.9) is the major fumonisin metabolite produced by the fungus, Fusarium moniliforme. The metabolite has been implicated as a carcinogen in animals (Holcomb et al., 1993). The structure is shown in Figure... 

Fumonisins. A group of mycotoxins and phytotoxins formed by the ascomycetes Gibberella fujikuroi (asexual form Fusarium moniliforme=F. verticilli-oides), a com pathogen, and Alternaria alternata f. sp. lycopersici, a tomato pathogen (AAL). 

Fumonisins have been isolated of the fungus Fusarium moniliforme MRC 826 from com intended for human consumption in Transkei, South Africa 190, 191) (Fig. 5.1 192,193), Table 5.1). 

Fumonisin Bi (249), the primary mycotoxin produced by the fungus Fusarium moniliforme, was first synthesized by McDonald et al. in 2009 (216). This group... 

Gelderblom WCA, Jaskiewicz K, Matasas WFO, Thiel PG, Horak RM, Vleggaar R, Kfiek NPJ (1988) Fumonisins — Novel Mycotoxins with Cancer-Pnnnoting Activity Produced by Fusarium moniliforme. J Appl Environ Microbiol 54 1806... 

Voss KA, Plattner RD, Riley RT, Meredithe FI, Norred WP (1998)/n vivo Effects of Fumonisin Bl-producing and Fumonisin B1-nonproducing Fusarium moniliforme Isolates are Similar Fumonisin B2 and B3 Cause Hepato- and Nephrotoxicity. Mycopathologia 141 45... 

Bermudez AJ, Ledoux DR, Rottinghaus GE (1995) Effects of Fusarium moniliforme Culture Material Containing Known Levels of Fumonisin B1 in Ducklings. Avian Dis 39 879... 

Voss KA, Riley RT, Bacon ChW, Qiamberlain WJ, Norred WP (1996) Subchronic Toxic Effect of Fusarium moniliforme and Fumonisin B1 in Rats and Mice. Nat Tox 4 16... 

Fumonisin Mycotoxin mainly produced by Fusarium moniliforme and Fusarium proliferatum that causes encephalitis and death in eqnines. In humans, it causes cancer and interferes with folic acid metabolism. It is believed to increase the chances of neural tube defects in developing fetuses. 

The fumonisins are related structurally to AAL-toxin (Fig. 1), but are produced by Fusarium moniliforme, F, proliferatum and other Fusaria of the Liseola section (57, 76). Recently, it has been reported by Chen et al., (31) that small amounts of FBj were produced by Alternaria alternata f sp. lycopersici as well, although this finding has been disputed by others. Recently, Abbas and Riley (14) reported that. alternata produces small amounts of FBj, FB2 and FB3 as well as AAL-toxin. 

Abbas, H.K., Vesonder, R.F., Boyette, C.D., Hoagland, R.F., and Krick, T. 1992. Production of fumonisins hy Fusarium moniliforme cultures isolated from jimsonweed in Mississippi. J. Phytopathology 136 199-203. 

Abbas, H.K. and Riley, R.T. 1995. The presence of the fumonisins and AAL-toxin m Alternaria alternata and Fusarium moniliforme. Toxicon (In press). 

Abbas, H.K. and Shier, W.T. 1992. Evaluation of biosynthetic precursors for the production of radiolabeled fumonisin B, by Fusarium moniliforme on rice medium. Abstracts of the 106th Association of Official Analytical Chemists Meeting Cincinnati, OH AOAC International Arlington, VA, pp. 236. 

ApSimon, J.W., Blackwell, B.A., Edwards, O.E., Fruchier, A., Miller, J.D., Savard, M., and Young, J.C. 1994. The chemistry of fumonisins and related compounds. Fumonisins from Fusarium moniliforme chemistry, structure and biosynthesis. Pure Appl. Chem. 66 2315-2318. 

Branham, B.E. and Plattner, R.D. 1993. Isolation and characterization of a new fumonisin from liquid cultures of Fusarium moniliforme. J. Natural Products 56 1630-1633. 

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