Functional magnetic nanoparticles

Ito A et al (2005) Medical application of functionalized magnetic nanoparticles. J Biosci Bioeng 100 1-11... 

Li Wang, Xian-Xue Gan (2009) Biomolecule-functionalized magnetic nanoparticles for flowthrough quartz crystal microbalance immunoassay of aflatoxin Bl. Bioprocess Biosyst Eng 32 109-116... 

Table 6.8 Summary of the results obtained for C—C cross-coupling reactions conducted in the presence of functionalized magnetic nanoparticles (74).

Ghosh, S., Hui, T., Uddin, M. S., Hidajat, K. (2013). Enantioselective separation of chiral aromatic amino acids with surface functionalized magnetic nanoparticles, 105, 267-277. 

Uridine diphosphate glucose (UDP-Glc) serves as a glucosyl donor in many enzymatic glycosylation processes. A multiple enzyme, one-pot, biocatalytic system was developed for the synthesis of UDP-Glc from low cost raw materials maltodextrin and uridine triphosphate. Three enzymes needed for the synthesis of UDP-Glc (maltodextrin phosphorylase, glucose-l-phosphate thymidyly-transferase, and pyrophosphatase) were expressed in Escherichia coli and then immobilized individually on amino-functionalized magnetic nanoparticles. The conditions for biocatalysis were optimized and the immobilized multiple-enzyme biocatalyst could be easily recovered and reused up to five times in repeated syntheses of UDP-Glc. After a simple purification, approximately 630 mg of crystallized UDP-Glc was obtained from 1 L of reaction mixture, with a moderate yield of around 50% (UTP conversion) at very low cost. ... 

Figure 2.11 Time course curves of the repeated UDP-Glc production using three enzymes (MalPase, GlPTTase, and PPase) immohilized on amino-functionalized magnetic nanoparticles. Reaction conditions MalPase, 18 U L GlPTTase, 100 U L PPase, 25 U L" maltodextrin, 5% (m/v) UTP, 2 mM MgCh, 10 mM buffer, sodium phosphate, pH 7.5, 100 mM 30 °C total volume, 200 mL.

Chouhan et al. (2007) found that Cu(I)-catalyzed C-N coupling reactions between aryl/heteroaryl bromides and azoles could be efficiently facilitated by the proline-functionalized magnetic nanoparticles (MNPs). Generally, the desired A-aryl/A-heteroaryl azoles (including pyrazoles, indoles, and benzimidazoles) were synthesized in good to excellent yields (Scheme 4.27). 

The use of nanomaterials [545] such as gold nanoparticles and carbon nanotubes increases the sensor surface and enhances analytical detection. The use of PEGylated arginine functionalized magnetic nanoparticles for early detection of cervical cancer has been reported [553]. This sensor displayed good selectivity and sensitively down to 10 cells mL ... 

Lyu YK, Kyung KJ, Lee WX (2009) Functionalized magnetic nanoparticles with poly (3-thiophenaacetic acid) and its application for electrogenerated chemiluminescence sensor. Synth Met 159 571-575... 

Zhang J, Rana S, Srivastava RS, Mishra RDK (2008) On the chemical synthesis and drug delivery response of folate receptor or activated, polyethylene glycol-functionalized magnetic nanoparticles. Acta Biomater 4 40-48... 

Yallapu MM, Othman SF, Curtis ET, Gupta BK, Jaggi M, Chauhan SC (2011) Multi-functional magnetic nanoparticles for magnetic resonance imaging and cancer therapy. Biomaterials 32 1890... 

Liu JC, Chen WJ, Li CW, Mong KK, Tsai PJ, Tsai TL, Lee YC, Chen YC. Identification otPseudomonas aeruginosa using functional magnetic nanoparticle-based affinity capture combined with MALDI MS analysis. Analyst. 2009 134(10) 2087 94. doi 10.1039/b908069d. 

Functional magnetic nanoparticles (MNPs) have become increasingly popular for applications in (asymmetric) catalysis, either as simple supports or as active components. Transition-metal catalysts and organocatalysts have been immobilized on MNPs not only to facilitate catalyst recovery and separation but also to achieve new levels of reactivity and selectivity. 

Figure 11.3 Principle of enhancing the binding strength of boronic acid-functionalized magnetic nanoparticles toward glycoproteins through dendrimer-assisted synergistic binding. (Reproduced from ref. 44 with permission. Copyright 2013, Royal Society of Chemistry.)...

W. Zhou, N. Yao, G. Yao, C. Deng, X. Zhang and P. Yang, Facile synthesis of aminophenylboronic acid-functionalized magnetic nanoparticles... 

S. Zhang, X. He, L. Chen and Y. Zhang, Boronic acid functionalized magnetic nanoparticles via thiol-ene click chemistry for selective enrichment of glycoproteins. New J. Chem., 2014,38(9), 4212-4218. 

Zamfir, L.-G., Geana, L, Bourigua, S. et al. (2011) Highly sensitive label-free immunosensor for ochratoxin A based on functionalized magnetic nanoparticles and EIS/SPR detection. Sens. Actuators, B, 159, 178-184. 

Lin P-C, Tseng M-C, Su A-K, Chen Y-J, Lin C- C. Functionalized magnetic nanoparticles for small-molecule isolation, identification, and quantification. Anal Chem 2007 79 3401-8. 

An easily replaceable microchip enzymatic microreactor has been fabricated based on the glass microchip with trypsin-immobilized superparamagnetic nanoparticles (Figure 10.16) [85]. Magnetic nanoparticles (50 nm in diameter) were synthesized. Amine-functionalized magnetic nanoparticles with high magnetic... 

Mazac, K., and Kirschning. A. (2008) Inductive heating for organic synthesis by using functionalized magnetic nanoparticles inside microreactors. Angew. Chem., Int. Ed., 47 (46). 8950-8953. 

Streptavidin functionalized magnetic nanoparticles modified gold electrode CV and EIS Label-free detection method 50 pmol of HBV DNA on sample of 20 pL [90]... 

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