Friend leukaemia

Nectrisine (an inhibitor of both a-glucosidases and a-mannosidases) has also been reported to have anti-viral activity. It has been shown to inhibit the retrovims Friend leukaemia vims in vivo in mice and it too can potentiate the activity of AZT. ... 

Nectrisine also has anti-viral activity and inhibits the retrovirus Friend leukaemia virus in vivo in mice and can potentiate the activity of AZT (zidovudine) [103]. Synergistic activity has also been shown when castanospermine and AZT are used in combination therapy in vitro [104], In vivo combination studies with V-butyl-deoxynojirimycin and AZT in human patients mdicated anti-viral activity but caused diarrhoea, abdominal pain and weight loss [103], Chemical modification of V-butyl-deoxynojirimycin to make it better tolerated was suggested. 

Friend leukaemia cells (Ferrantini et al. 1993, 1994), and TNF-y gene C1300 neuroblastoma cells (Watanabe et al. 1989), CMS-5 fibrosarcoma cells (Gansbacher et al. 1990), SPl and CT-26 colon carcinoma cells (Esumi et al. 1991). 

Tumours may be induced at various sites in a variety of animals by physical, chemical and viral agents. Chemical induction is the method most frequently used and involves tumour induction by carcinogenic compounds. Thus, 3,4,9,10-dibenzopyrene induces fibrosarcomas in weanling Swiss mice within 10-15 weeks of subcutaneous implantation [17]. Two virally-induced tumours have been used for detecting antitumour activity. These are the Friend leukaemia [18] and Rous sarcoma [19]. The former system is of interest as it is sensitive to a wide spectrum of antitumour agents. 

Numerous structural modification studies of ellipticine have been conducted. It is found that side-chain substitution has considerable influence on the biological activity to compounds of this type. A pyridopyrrolo[2,3-g]iso-quinoline derivative, BD-40 (48) [235, 236], has demonstrated potent activity against many different experimental tumours including leukaemia L1210 and the Friend virus leukaemia. It is also active against the Moloney strain of murine sarcoma virus [237]. Phase I clinical study of (48) has been conducted [238, 239]. 

Riggs MG et al (1977) n-Butyrate causes histone modification in HeLa and Friend erythro-leukaemia cells. Nature 268(5619) 462-464... 

The Friend spleen focus-forming virus encodes a glycoprotein (mol. wt. 5.5x10 ). Although it appears to be structurally related to the lymphatic leukaemia viral glycoprotein (mol. wt. 7.5 X 10 ), the former glycoprotein has distinctive structural features in the polypeptide portion of the molecule. 

Chlorite-oxidized amylose (oxyamylose) has been found to possess a leukaemo-suppressive activity against established Friend virus leukaemia. ... 

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