Fourier transform ion cyclotron mass

Wang F, Weidt S, Xu J, Mackay CL, Langridge-Smith PRR, Sadler PJ (2008) Identification of clusters from reactions of ruthenium arene anticancer complex with glutathione using nanoscale liquid chromatography fourier transform ion cyclotron mass spectrometry combined with 180-labeling. J Am Soc Mass Spectrom 19 544-549... 

Fig. 13.6 Nudicaulin pigments isolated from Papaver nudicaule and analyzed using high-resolution ESI-Fourier transform ion cyclotron mass spectrometry.

FIGURE 4.5 Continued, (d) ESI quadrupole time-of-flight mass spectrometer and (e) ESI Fourier transform ion cyclotron mass spectrometer. CID = collision-induced dissociation, Q = quadrupole mass analyzer, q = RE only ion guide, D = detector, P = pusher electrode, MSI = first stage of mass spectrometry, MS2 = second stage of mass spectrometry, and PSD =... 

Fourier transform ion cyclotron mass spectrometry (FT-ICR-MS) instrumentation offers excellent sensitivity, accuracy (<1 ppm), and high mass resolution (>1,000,000) (Table 10.2). However, because of being too expensive, difficult to use, and not compatible with conventional HPLC columns and flow rates, FTMS has not been frequently used in pharmaceutical research. This changed with an introduction of a hybrid instrument consisting of a linear ion-trap mass spectrometer compatible with LC and an ion-cyclotron-resonance (ICR) detector. Such a hybrid instrument is compatible with conventional HPLC and allows for acquisition of accurate mass data-dependent MS" spectra. Sanders et al. [128] recently reviewed the utility of hybrid LTQ-FTMS for drug metabolism and metabonomics applications while Brown et al. [129] reviewed the metabolomics applications of FT-ICR-MS. 

The covalent interactions of small molecules with DNA have also been studied using electrospray. The use of liquid chromatography in conjunction with electrospray has been reviewed. The use of electrospray in conjunction with capillary electrophoresis has also been investigated. The stabilities of duplexes formed from 3, 5 - and 2, 5 - linked DNA have been compared by electrospray The binding of metal ions to oligonucleotides has also been studied using electrospray ionisation,Fourier transform ion cyclotron mass spectrometry. ... 

A sample contains a mixture of three compounds, the molecular ions of which can be separated by a mass spectrometer at a resolution of 9500. Your laboratory is equipped with the following instruments (a) a double-focusing magnetic-sector spectrometer, (b) a single-quadmpole spectrometer, (c) a quadrupole ion-trap spectrometer, (d) a linear time-of-flight (TOP) spectrometer, (e) a refiectron-TOF spectrometer, and (f) a Fourier transform ion cyclotron mass spectrometer. Suggest aU possible choices among these instruments that you can employ for the analysis of this mixture. 

H. A. HofstadlCT, J. H. Wahl, et al.. Capillary electrophoresis Fourier transform ion cyclotron mass spectrometry with sustained off-resonance irradiation for the characterization of proteins and peptides, J. Am. Soc. Mass Spectrom. 5, 894-899 (1994). 

Van der Flage and co-workers [280] combined MALDI and Fourier transform ion cyclotron mass spectrometry (FT-ICR-MS) for the characterisation of polyoxyalkyleneamines. MALDI FT-ICR-MS was used to resolve intact, sodium ion cationised oligomer ions in the mass range from m/z 500 to 3500. NMR was used to measure the average end-group distribution to provide insight into conformational differences. In this respect, FT-ICR-MS and NMR data were complementary. Combined results yielded detailed information about chemical composition distributions of polyalkyleneamines that hitherto it was not possible to obtain with either technique separately. Merits and limitations of the data produced with MALDI FT-ICR-MS are discussed and compared with those of H and C NMR data [280]. 

Recently, we have used electron spray ionization Fourier transform ion cyclotron mass spectrometry (ESI-FTICRMS) to intercept and characterize several organome-tallic species in Pd-catalyzed reactions of 2,3-allenoate with two organoboronic adds... 

Barshick CM, Eyler JR. A glow dischaige ion source with Fourier transform ion cyclotron mass spectrometric detection. J Am Soc Mass Spectrom. 1992 3 122-7. 

Aharoni, A. et al. (2002) Non-taigeted metabo-lome analysis by use of Fourier transform ion cyclotron mass spectrometry. Omics 6,217-234... 

Sannes-Lowery, K.A. Hofstadler, S.A. Sequence Confirmation of Modified Oligonucleotides Using IRMPD in the External Ion Reservoir of an Electrospray Ionization Fourier Transform Ion Cyclotron Mass Spectrometer. J. Am. Soc. Mass Spectrom. 2003,14, 825-833. 

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