Formoterol

Molecular formula CigH24N204 Molecular weight 344.40 CAS Registry No 73573-87-2 Merck Index 13, 4269 [Pg.279]

HPLC VARIABLES Guard column 10 x 2 R2 Chromsep Column 200 x 3 5 xm H5rpersil ODS Column temperature 33 [Pg.279]

Mobile phase MeCN MeOH buffer 5 25 70 (The buffer was 35 mM potassium dihy-drogen phosphate 35 mM disodium hydrogen phosphate 87.7 12.3 containing 20mgAi EDTA, pH 6.) [Pg.279]

Detector E, Model Decade (Antec, Leiden, Netherlands), VT-03 flowcell, working electrode with a 50 thickness spacer, potential -1-0.63 V in DC mode [Pg.279]

Internal standard 3-acetylamino-4-hydroxy-a- [iV- [l-methyl-2-(p-methoxyphenyl) ethyl] aminomethyl]benzyl alcohol (CGP 47086A) (19) [Pg.279]

Formoterol fumarate (Foradil Aerolizer) is administered only by oral inhalation using the Aerolizer Inhaler. [Pg.342]

C9H13NO 104-63-2) see Indeloxacine Phenmetrazine 7-(2-benzylaminoethyl)theophylline (C15H19N5O2 22680-61-1) see Fenetylline Theodrenaline benzyl [(2R,35)-3-amino-2-hydroxy-4-phenylbutyl](2-methylpropyl)carbamate monohydrochloride (C22H3[C1N20j 160232-11-1) see Amprenavir 2-benzylamino-l-(4-methoxyphenyl)propane (C17H21NO 43229-65-8) see Fenoterol Formoterol benzyl [3-[(2-aminophenyl)carbamoyl]propyl]methyl> carbamate... [Pg.2304]

C33H3 N204 43229-70-5) see Formoterol l-(4-hydroxy-3-methoxyphenyl)-l -propanediol 2-formate... [Pg.2397]

Add standing treatment with one or more long-acting bron-chodilators (i.e., tiotropium, salmeterol, and formoterol)... [Pg.149]

Salmeterol and formoterol are long-acting inhaled p2-agonists that provide up to 12 hours of bronchodilation after a single dose. Both agents are approved for the chronic prevention of... [Pg.218]

Although both formoterol and salmeterol are effective as add-on therapy for moderate persistent asthma, neither agent should be used as monotherapy for chronic asthma. Patients treated with salmeterol alone are at greater risk of worsening asthma than those treated with inhaled corticosteroids.25,26... [Pg.218]

Salmeterol is also available in a fixed ratio combination product containing fluticasone, and a new drug application has been filed for a fixed combination product containing budesonide and formoterol. Combination products have the potential advantage of increasing patient adherence due to the decreased number of inhalers and inhalations however, these products offer less flexibility with respect to dosage adjustments when necessary. [Pg.218]

Formoterol DPI 12 mcg/single-use capsule 1 capsule every 12 hours 1 capsule every 12 hours... [Pg.221]

Long-Acting p2 Agonists Formoterol Inhalation 1-3 minutes 1-3 hours 12 hours Powder (12 mcg/inhalation)... [Pg.237]

US patent 6,720,453, Formoterol tartrate polymorph [105], A method of preparation of a highly pure salt of R,R-formoterol L-tartrate is disclosed. The process provides the most thermodynamically stable polymorph by recrystallization of a novel polymorph. [Pg.278]

ADRB2) antagonists (salbutamol, formoterol) airway responsiveness to beta-2-adrenergic receptor antagonists in asthmatics (24) in asthmatic (23) and severity of asthma (92)... [Pg.66]

Lipworth BJ, Dempsey OJ, Aziz I. Functional antagonism with formoterol and salmeterol in asthmatic patients expressing the homozygous glycine-16 beta[2]-adrenoceptor polymorphism. Chest 2000 118[2] 321—328. [Pg.79]

Several recent articles describe the ring-opening of chiral epoxides under microwave irradiation conditions (see also Scheme 6.103). In the context of the preparation of novel /32-adrenoceptor agonists related to formoterol and salmeterol, Fairhurst and a team from Novartis have described the synthesis of chiral ethanolamines by solvent-free microwave-assisted ring-opening of a suitable chiral epoxide precursor with secondary benzylated amines (Scheme 6.129) [262]. At 110 °C, the reaction occurred... [Pg.193]

Several studies have shown an additive effect with the combination of inhaled corticosteroids and long-acting bronchodilators. Combination therapy with salmeterol plus fluticasone or formoterol plus budesonide is associated with greater improvements in FEVj, health status, and exacerbation frequency than either agent alone. The availability of combination inhalers makes administration of both drugs convenient and decreases the total number of inhalations needed daily. [Pg.941]

Jeppsson A-B, Nilsson E, Waldeck B (1994) Formoterol and salmeterol are both long acting compared to terbutaline in the isolated perfused and ventilated guinea-pig lung. Eur J Pharmacol 257 137-143. [Pg.158]

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