Food additive safety

Taliaferro p j (1995), Monosodium glutamate and the Chinese restaurant syndrome a review of food additive safety J Environ Health, 57(10), 8-12. taylor s l and bush r K (1986), Sulfites as food ingredients, a Scientific Status Summary by the Institute of Food Technologists Expert Panel on Food Safety Nutrition , Food Technol, 40(6), 47-52. taylor s L and hefle s l (2001), Food allergies and other sensitivities, a Scientific Status Summary by the Institute of Food Technologists Expert Panel on Food Safety Nutrition , Food Technol, 55(9), 68-83. 

The Use of Food Additive Safety Evaluation Procedures as a Basis for Evaluating the Safety of New Pharmaceutical Excipients... 

The FDA Center for Food Safety and Applied Nutrition (CFSAN), Office of Food Additive Safety (OFAS) is responsible for reviewing food and color additive petitions and GRAS Notifications (13). OFAS has four divisions ... 

In a recent article, the FDA stated For excipients with a history of use, it may be possible to adequately address some or all of the safety issues through citation of the existing nonclinical and clinical database, marketing history, or regulatory status of the compound (e.g., GRAS status as a direct food additive may adequately support oral administration of that compound up to the levels permitted in foods) (25). Therefore, it appears reasonable that the FDA would consider the use safety data based on the food additive regulatory status of an excipient to evaluate the safety of the excipient. If a new excipient has undergone a food additive safety review, this may reduce the perceived risks associated with the development and use of a new excipient. 

Mitchell Cheeseman, James Wallwork. FDA s Office of Food Additive Safety. Food Safety Magazine 2002. 

U.S. Food and Drug Administration. 2007. Toxicological principles for the safety assessment of food ingredients redbook 2000. CFSAN/Office of Food Additive Safety (July 2000 updated July 2007). Rockville, MD U.S. FDA. 

The USFDA approach to assessing exposure to migrants from FCMs is explained in CFSAN/Office of Food Additive Safety, April 2002 and is available on their web site (http //www.cfsan.fda.gov/). It describes the use of exposure estimates for use in food contact notifications (FCNs) which would normally be based upon simulant rather than food migration data, as is the case for new materials. The USFDA approach is described in more detail in Chapter 2. In the USFDA approach a consumption factor is combined with a food distribution factor and concentration data to derive an estimate of exposure from all food types and all FCMs containing the substance of interest. 

Within the FDA s Center for Food Safety and Applied Nutrition, the Office of Food Additive Safety administers premarket approval processes for new direct food additives and food additives that are components of food contact materials. Most food contact materials are regulated via the food contact notification process and authorization of new food contact materials is administered by the Division of Food Contact Notifications (see Chapter 2 for further information). The notifier has the primary responsibility to demonstrate the safety of the proposed use of the food contact material. Review scientists within FDA perform a fair evaluation of the data in a food contact notification, as well as other relevant information, to determine if the knowledge base supports the finding with reasonable certainty that no harm will result from the intended use of the food additive. FDA maintains a number of public online listings that include useful information... 

Dr Michelle Twaroski, Dr Layla Batarseh and Dr Allan Bailey Office of Food Additive Safety HFS-... 

U.S. Food and Drug Administration, Cento for Food Safety and AppUed Nutrition, Office of Food Additive Safety, Recycled Plastics in Food Packaging, Oct. 2003, http //www.cf-san.fda.gov/-dms/( -recyJitml. 

In the United States infant formulas and ingredients added to infant formulas fall within the purview of the Office of Food Additive Safety and the Office of Nutritional Products, Labeling and Dietary Supplements of FDA s Center for Food Safety and Applied Nutrition. The safety of new ingredients added to infant formulas is regulated under Section 409 of the Federal Food, Drug and Cosmetic (FD C) Act (21 U.S.C. 348), which was the primary focus of the committee. 

Arvidson, K.B., Chanderbhan R., Muldoon-Jacobs, K., et al., 2010. Regulatory use of computational toxicology tools and databases at the United States Food and Drug Administration s Office of Food Additive Safety 6, 793-796. 

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