Folic acid nanoparticles

A.J. Ditto, K.N. Shah, N.K. Robishaw, M.J. Panzner, W.J. Youngs, Y.H. Yun, The interactions between 1-tyrosine based nanoparticles decorated with folic acid and cervical cancer cells under physiological flow. Mol. Pharm. 9 (2012) 3089-3098. 

Yang et al. [138] produced high-performance nanoparticles for photodynamic detection of colorectal cancer, where alginate is physically complexed with folic acid-modified chitosan to form nanoparticles with improved dmg release in the cellular lysosome. They are excellent vectors for colorectal-specific delivery of 5-aminolevulinic acid for fluorescent endoscopic detection [138]. 

Bright field, confocal and superimposed images of live human ovarian carcinoma cells (0VCAR3, top row) and human colonic adenocarcinoma cells (HT29, bottom row), with PEI/NaYF4 nanoparticles attached. The nanoparticles were surface modified with folic acid. 

Fig. 9 Bright field (a) and confocal-fluorescence (b) images of human colonic adenocarcinoma cells (HT29) incubated with folic acid functionalised PEl/NaYF4 Yb3r nanoparticles. Intradermal injection of PEI/NaYF4 Yb,Er nanoparticles (to an approximate depth of 5 mm) on shaved rat abdominal skin (d) shows fluorescence on excitation with near-inlxared laser. Similar injection of quantum dots (c) does not show fluorescence on excitation with UV. Reprinted with permission from [54]. Copyright 2008...

Folic acid-modified carboxymethyl chitosan nanoparticles Sonication Drug carrier for tumor-specific drug delivery [241]... 

Tan YL, Liu CG (2011) Preparation and characterization of self-assemblied nanoparticles based on folic acid modified carboxymethyl chitosan. J Mater Sci Mater Med 22 1213-1220... 

Narayanan et al. reported targeted NP-mediated delivery to enhance the efficacy of the well-known nutraceutical GSE. NanoGSE was prepared by a nanoprecipitation technique whereby GSE was encapsulated in PLGA nanoparticles. The potential cancer-targeting ligand folic acid was conjugated to GSE-PLGA NPs and tested... 

Research on oral liposomal delivery systems has moved forward with the development of polymer-modified liposomes. For example, targeted PEGylated liposomes furnished with folic acid for oral delivery were promising, showing enhanced permeability of dextran (used as a marker) across Caco-2 cell monolayers (Anderson et al., 1999). PEG and chitosan-coated lipid nanoparticles were constmcted as oral delivery systems for salmon calcitonin (sCT). The PEG-coated nanoparticles did not alter the transepithelial electrical resistance of Caco-2 cell monolayers, while the chitosan-coated nanoparticles showed a dose-dependent increase in the permeability of dextran across the monolayers (Garcia-Fuentes et al., 2005). It demonstrated that the favourable interaction of the chitosan-coated nanoparticles with intestinal mucosa, together with their permeation enhancing characteristics, could improve the oral absorption of sCT. 

Haidary SM, Corcoles EP, Ali NK (2013) Folic acid delivery device based on porous silicon nanoparticles synthesized by electrochemical etching. Int J Electrochem Sci 8 9956-9966 Heirlings L, Siro I et al (2004) Influence of polymer matrix and adsorption onto silica materials on the migration of alpha-tocopherol into 95 % ethanol from active packaging. Food Addit Contam 21 1125-1136... 

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