Cancer target

Arias, J.L., Lopez-Viota, M., Lopez-Viota, J. and Delgado, A.V. (2010) Iron/ ethylcellulose (core/shell) nanoplatform loaded with 5-fluorouradl for cancer targeting. Colloids and Surfaces B Biointerfaces, 77, 111—116. 

Camero A. (2002) British J. Cancer, Targeting the cell cycle for cancer therapy, 87, 129-133. 

Humanized Antibodies To further improve the avidity and reduce antigenicity, only the specific antigen-binding region is derived from mouse, while the remainder of the antibody is constructed using human proteins. These are the humanized antibodies and include the breast cancer targeting MAb called Herceptin (see Case Study 4). 

Aina OH, et al. Therapeutic cancer targeting peptides. Biopol5uners 2002 66 184. 

Carver LA, Schnitzer JE. Caveolae mining little caves for new cancer targets. Nat Rev Can 2003 3(8) 571-581. 

The first key question in the process of validating a cancer target is whether the target is necessary for the maintenance of a phenotype associated with transformation, i.e. Can the tumor survive and progress upon modulation of this target Experiments designed to address this question are frequently referred to as loss-of-function experiments and typically require knockdown of... 

To further assess the clinical relevance of a particular cancer target it may be necessary to determine the association of the target protein levels, its localization, and/or its activity with a specific cancer type, stage, or prognosis. This will often require the generation and, most importantly, validation of robust antibodies for immunohistochemistry (IHC) to be used on tissue microarrays (TMAs) encompassing the relevant tumor types and, ideally, matched normal samples. 

Morgan-Lappe SE, Tucker LA, Huang X et al (2007) Identification of Ras-related nuclear protein, targeting protein for xenopus kinesin-like protein 2, and stearoyl-CoA desaturase 1 as promising cancer targets from an RNAi-based screen. Cancer Res 67 4390-4398... 

Gao XH, Cui YY, Levenson RM, Chimg LWK, Nie SM (2004) In vivo cancer targeting and imaging with semiconductor quantimi dots. Nat Biotechnol 22 969-976... 

Galanis E, Vile R, Russell SJ. 2001. Delivery systems intended for in vivo gene therapy of cancer Targeting and replication competent viral vectors. Crit Rev Oncol Hematol. 38 177-192. 

Hasegawa T, Fujisawa T, Haraguchi S et al (2005) Schizophyllan-folate conjugate as a new non-cytotoxic and cancer-targeted antisense carrier. Bioorg Med Chem Lett 15(2) 327—330... 

Buchanan, M.S., et al (2007). Spermatinamine, the first natural product inhibitor of isoprenylcysteine carboxyl methyltransferase, a new cancer target. Bioorg Med Chem Lett 17 3. 

---