Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Flubendiamide ryanodine receptors

Agricultural Research, Technology Portfolio, Tools, Discovery Platform, Mode of Action, Flubendiamide, Ryanodine Receptor... [Pg.63]

New agrochemicals introduced in the past five years include new chemistries with known modes of action, such as the protoporphyrinogen inhibitor bencarba-zone, the phytoene desaturase picolinafen and beflutamid, and sodium channel pyrethroids new chemistries with possibly new modes of action, such as flonic-amid and pyridalyl and new chemistries with established new modes of actions, such as flubendiamide, which activates ryanodine-sensitive intracellular calcium release channels, ryanodine receptors RyR, in insects. [Pg.157]

DuPont has also introduced a new class of insecticides, the anthranilic diamides, such as DP-23 [205], which, like flubendiamide, also act by activating the ryanodine receptor [206],... [Pg.164]

Flubendiamide, a benzenedicarboxamide insecticide, also affects calcium channels. This insecticide induces unique symptomology in poisoned insects, showing a gradual contraction of the insect body. It is believed that flubendiamide induces intracellular Ca2+ release mediated by a calcium channel such as the ryanodine receptor resulting in the contraction of insect muscle (Tohnishi et al., 2005 Ebbinghaus-Kintscher et al., 2006 Nauen, 2006). [Pg.122]

Calcium channels (ryanodine receptor) Ryanodine, flubendiamide, chlorantraniliprole Activation... [Pg.139]

This hypothesis was further supported using molecular biology and cellular tools where the insect ryanodine receptor gene was heterologously expressed in appropriate cells. In untransfected CHO cells, application of flubendiamide sulfoxide (a better soluble analogue) did not cause an [Ca ] increase (Figure 8). In CHO cells transfected with the RyR from Drosophila (CHO-RyR), flubendiamide sulfoxide induced Ca responses with similar kinetic responses to those found in Heliothis neurons (Figure 8). [Pg.60]

Therefore it was concluded that flubendiamide acts as a selective activator of the insect ryanodine receptor, inducing ryanodine-sensitive cytosolic Ca transients. Furthermore, radioligand binding studies using microsomal membranes from Heliothis flight muscles demonstrated that flubendiamide allosterically increased the ryanodine affinity. Flubendiamide was found to bind to Heliothis microsomal membranes with an apparent of 4.7 nM. Known ryanodine receptor ligands such as cyclic ADP-ribose, caffeine, ryanodine, and dantrolene did not interfere... [Pg.60]

Flubendiamide is most effective on larvae followed by adults, but it has no ovicidal activity. In the course of extensive research on the mode of action of flubendiamide, it was determined that flubendiamide was a ryanodine receptor modulator. Flubendiamide Axes the Ca-channel of insect ryanodine receptors (RyR) in the open state, and subsequently induces calcium release from the membrane vesicle... [Pg.132]

Flubendiamide, Benzenedicarboxamide, Insecticide, Ryanodine Receptor Modulator... [Pg.135]

Flubendiamide, a novel insecticide, selectively activates lepidopterous ryanodine receptor (S. Kiyonaka, Kyoto Univ., Japan)... [Pg.481]

The current study shows that phthalic acid diamide insecticides, represented by flubendiamide and its sulfoxide analogue, activated ryanodine receptors present in isolated Heliothis neurons, as concluded from the following results. Firstly, calcium transients evoked by phthalic acid diamides were independent of the extracellular [Ca ], in contrast to the signals elicited by acetylcholine. This was interpreted as calcium release from intracellular stores of the endo(sarco)plasmic reticulum, which could in principle be mediated by two different release channels, namely the ryanodine receptor and the IP3 receptor. [Pg.244]

It is noteworthy that the inactivation of the Heliothis RyR at millimolar [Ca ] was prevented at all flubendiamide concentrations tested. This could plausibly explain the insecticidal mechanism since deactivation of calcium release channels at high [Ca ] would be essential to terminate the intracellular calcium transient (27). According to this hypothesis, ryanodine receptors would be fixed in the (sub)conductance conformation leading to calcium store depletion and, possibly, to subsequent activation of capacitative calcium entry through plasma membrane channels. This would override compensatory calcium removal mechanisms such as the sarcoplasmic Ca-ATPase (SERCA) activity and the sodium-calcium exchanger (NCX) in the plasma membrmie. The sustained high intracellular [Ca would finally lead to muscle contraction paralysis that is consistently observed in flubendiamide-affected lepidopteran larvae. [Pg.246]

Flubendiamide Selectively Activated Insect ryanodine Receptors... [Pg.247]

When increasing the calcium concentration to 800 pM, specific binding of ryanodine could be fitted to the simple hyperbolic equation with n = 1.0 (Figure 4B). The Kd of ryanodine was calculated as 13.6 +/- 1.4 nM (4 experiments) d the receptor density was determined as 1086 finol/mg. Flubendiamide-sulfoxide (1.0 pM) decreased the apparent Kq slightly, but still significantly, to 7.9 +/- 0.9 nM (t-test p < 0.03). [Pg.240]


See other pages where Flubendiamide ryanodine receptors is mentioned: [Pg.163]    [Pg.60]    [Pg.461]    [Pg.509]    [Pg.765]    [Pg.1125]    [Pg.1125]    [Pg.1135]    [Pg.235]    [Pg.246]   
See also in sourсe #XX -- [ Pg.246 ]




SEARCH



Flubendiamide

Ryanodin

Ryanodine receptor

© 2024 chempedia.info