Flubendiamide selectively activating insect

Flubendiamide Selectively Activated Insect ryanodine Receptors... 

Therefore it was concluded that flubendiamide acts as a selective activator of the insect ryanodine receptor, inducing ryanodine-sensitive cytosolic Ca transients. Furthermore, radioligand binding studies using microsomal membranes from Heliothis flight muscles demonstrated that flubendiamide allosterically increased the ryanodine affinity. Flubendiamide was found to bind to Heliothis microsomal membranes with an apparent of 4.7 nM. Known ryanodine receptor ligands such as cyclic ADP-ribose, caffeine, ryanodine, and dantrolene did not interfere... 

Flubendiamide represents a novel class of insecticide having a unique chemical structure, and provides a new mode of action, which acts as a RyR modulator. This activity is highly selective to insect RyR, and no cross-resistance to existing insecticides is observed. Flubendiamide will also be very suitable for Insecticide Resistant Management. Furthermore, flubendiamide shows a broad insecticidal spectrum against lepidopterous insect pests, excellent efficacy in field evaluations, and excellent safety against various beneficial arthropods and natural enemies. It will be suitable for 1PM programs. 

Flubendiamide is a novel insecticide possessing potent and selective activity against lepidopterous insects [1], This insecticidal activity has been clarified to be mediated by a ryanodine-sensitive calcium release channel (RyR) [2-3], The stabilization of RyR to open state by the compound induces robust calcium release from intracellular calcium store (Figure 1). This implies a significant impact on components involved in intracellular calcium homeostasis such as the pump, a pivotal component which reuptakes released Ca into SR. In this study, we examined effects on the Ca pump, as a consequence of the calcium mobilization induced by flubendiamide. 

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