Field evaluation methodologies

Cheng, H. H. Lehmann, R. G. In "Symposium on Assessment of Methodology for Field Evaluation of Herbicide Behavior in Soils". Weed Sci. 1985, (in press). 

Laboratory and Field Evaluations of a Methodology for Determining Hexavalent Chromium Emissions from Stationary Sources... 

Bromate stability was studied in two different dimensions. The first was related to direct evaluation of bromate stability in different water matrices. The second was devoted to stability of bromate species mobilized on activated alumina micro-columns with a view to developing a field sampling methodology from bromate in waters. 

AISI [I2-/4] luis taken a leadership role to develop and evaluate methodology based on laboratory experiments, field exposure history, and theoretical and empirical models through an open forum of all interested parties (mainly North American automotive and steel industries), organized as the Corrosion Task Force of the AISI. The task force developed an improved laboratory-accelerated test for ranking the cosmetic corrosion resistance of coated automotive steel sheet products. This approach serves as a model for methodology development in areas of nonmetaUic coatings corrosion testing. 

Hethmon, T., and S. Ludlow. 1997. Air sampling methodologies for sulfuric acid mist in copper electrowinning field evaluations and development of a new method. Applied Occupational and Environmental Hygiene 12(12) 1041-1046. 

As in many fields of research, new tools and techniques for measuring carotenoids in various systems are critical to support research progress. Several chapters discuss new methodologies to measure carotenoids (see Chapter 4), carotenoid metabolites/radicals (see Chapter 9), or carotenoids in vivo in complex biological systems, especially in the human eye (e.g., see Chapters 5 and 6). Other chapters describe the oxygenase enzymes that are essential components of carotenoid metabolism to active metabolites (see Chapter 19). The study of active metabolites includes the in-depth evaluation of carotenoid cleavage products (see Chapter 11) and carotenoid radicals (see Chapter 14) that may account for some of the biological actions observed for these unique substances. 

In the above-mentioned examples, the prediction of CYP-mediated compound interactions is a starting point in any metabolic pathway prediction or enzyme inactivation. This chapter presents an evolution of a standard method [1], widely used in pharmaceutical research in the early-ADMET (absorption, distribution, metabolism, excretion and toxicity) field, which provides information on the biotransformations produced by CYP-mediated substrate interactions. The methodology can be applied automatically to all the cytochromes whose 3 D structure can be modeled or is known, including plants as well as phase II enzymes. It can be used by chemists to detect molecular positions that should be protected to avoid metabolic degradation, or to check the suitability of a new scaffold or prodrug. The fully automated procedure is also a valuable new tool in early-ADMET where metabolite- or mechanism based inhibition (MBI) must be evaluated as early as possible. 

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