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Interacting compounds

Peptoid hbraries have also yielded compounds active in the disruption of RNA-protein interactions. Compounds not derived from library syntheses are discussed in Section 1.4.1. A peptoid 9-mer with a number of cationic groups was discovered (Fig. 1.4) after several rounds of mixture deconvolution, that was able to block the interaction of HIV-1 Tat protein with TAR RNA at nanomolar concentra-... [Pg.6]

Membrane-interactive compounds are lipophilic molecules which have high affinity for lipid membranes and consequently possess long membrane residence times. Examples include the lipophilic neutral molecules (cholesterol, lecithin, pesticides, oleyl alcohol, tocopherols, etc.) and large organic cations (chlorproma-... [Pg.313]

In conclusion, Eqs. (140) and (141) are applicable to quantify not only the transmonolayer kinetics of highly membrane interactive permeants, but also the kinetics of less membrane interactive compounds. Notably, the examples emphasize the importance of simultaneously measuring the disappearance of a compound from the donor solution and its appearance in the receiver and demonstrate how interactions with proteins on either side of the cellular barrier influence permeability. [Pg.325]

Table 16.1 QSPR and pharmacophore models for P-gp interacting compounds. [Pg.373]

Sun D, Thompson B, Gathers BE, Salazar M, Kerwin SM, Trent JO, Jenkins TC, Neidle S, Hurley LH (1997) Inhibition of human telomerase by a G-quadruplex-interactive compound. J Med Chem 40 2113-2116... [Pg.188]

A special case is when the electrochem-ically active components are attached to the metal or carbon (electrode) surface in the form of mono- or multilayers, for example, oxides, hydroxides, insoluble salts, metalloorganic compounds, transition-metal hexacyanides, clays, zeolites containing polyoxianions or cations, intercalative systems. The submonolayers of adatoms formed by underpotential deposition are neglected, since in this case, the peak potentials are determined by the substrate-adatom interactions (compound formation). From the ideal surface cyclic voltammetric responses, E° can also be calculated as... [Pg.14]

Key Words Ras Raf yeast two-hybrid system protein interaction compound library cell-based screening. [Pg.253]

Rollag JG, Nachi R, Schlesiger L, et al. The resolution of ion suppression caused by drug-interaction compounds. (2001) ASMS Conference Proceedings. [Pg.179]

A second strategy was recently proposed that both increases the sensitivity and allows in certain cases more direct information about the binding site of the interacting compounds [115], It is based on correlation experiments... [Pg.303]

An x-ray crystallographic analysis of bcnzo[J,2,3- / 4,5,6-cV ]bis(thieno)[2,3-c]thiophene (61) demonstrated that the molecule is planar and symmetrical but has strained bond angles. The crystal structure comprises herring-bone type column stacking with intercolumnar heteroatom interactions. Compound (61) showed the same oxidation potential as perilene and, like perilene, formed an iodine complex with the relatively high electroconductivity of 0.11 S cm-1 <93BCJ2033>. [Pg.8]


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Aroma compounds interactions

Aroma compounds wine macro-components interactions

Aromatic compounds supramolecular interaction

Aromatic compounds, interactions

Aromatic compounds, interactions cyclodextrins

Aromatic hydrocarbon—polar group interaction compounds

Arsenic compounds enzyme interactions

Aryl Interactions fact or artifact A New Bonding Motif For Supramolecular Self-Assembly in Organotin Compounds

C-Glycosyl compounds SOMO-LUMO interactions

Carbonyl compounds Lewis acid-base interactions

Carbonyl compounds interaction effects

Carbonyl compounds interaction with Lewis acids

Carbonyl compounds, electron ligand interaction

Colored compounds, interaction

Compound-target interaction mode

Compounds identified from interaction

Compound—gene interaction

Coordination compounds Coulomb interactions

Coordination compounds interaction

Coordination compounds metal-ligand resonance interaction

Copper compounds interactions

DNA-Compound Interactions

Drug-receptor interactions lead compounds

Electrolyte sulfur compound, interactions

Electron donor-acceptor compounds interactions

Electron-phonon interaction in intermetallic compounds

Flavor compounds, interactions with

Flavor compounds, interactions with other food components

Fluorescent compounds, protein interaction with

Grape compounds interactions

Hydrophobic compounds interactions

Interaction compounds

Interaction effects, carbonyl compounds intramolecular

Interaction of NO with Organic Compounds

Interaction of Organic Compounds with Melanocortin Receptor Subtypes

Interaction of Organotin Compounds in Real and Model Membranes

Interaction with Organic Compounds

Interactions of Cyclic Peptides with Aromatic Compounds

Interactions of Light with a Chemical Compound

Interactions of Polyammonium Compounds with Isolated Acetylcholine Receptors

Interactions with Inorganic Salts, Fruit Acids, Purine Alkaloids, Phenolic Compounds and Ethanol

Interactions with Other Compounds

Interactions with aroma compound

Intermolecular interactions in organoantimony and organobismuth compounds

Iron compounds interactions

Laves phase compounds interaction

Ligand interactions lead compounds

Metal-diazo-compound interaction

Micelles interactions with biological compounds

Molecular Interactions Determining the Partitioning of Organic Compounds Between Different Phases

Organolead compounds, interactions with

Organometallic compounds interactions with biological

Organotin compounds interactions with biological

Organotin compounds protein interactions

Overlap interaction ionic compounds

Phenolic Compounds in Grapefruit and Citrus with Potential Drug Interactions

Platinum-sulfur interactions compounds

Possible Interactions of Sulfhydryl Groups and Quinonoid Compounds

Silica compounds protein interactions

Supramolecular compounds interactions

Thalmeier and B. Liithi, The electron—phonon interaction in intermetallic compounds

The interaction of an alcohol with a halogen compound under basic conditions

The interaction of carbonyl-containing compounds with organometallic reagents

Thermal interactions, volatile compounds

Urea inclusion compounds interactions

Yeast cell walls, interactions with aroma compounds

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