Fibrinolysis, and

Schreiber A, Kaplan A, Austen K Inhibition by 62 ClINH of Hageman factor fragment activation of coagulation, fibrinolysis, and kinin generation. J Clin Invest 1973 52 1402-1409. 

Collen D, Lijnen HR Basic and clinical aspects of fibrinolysis and thrombolysis. Blood 199T,78 3114. 

The inflammatory process in sepsis is linked to the coagulation system. Pro-inflammatory mediators maybe procoagulant and antifibrinolytic, whereas anti-inflammatory mediators may be fibrinolytic. A key factor in the inflammation of sepsis is activated protein C, which enhances fibrinolysis and inhibits inflammation. Protein C levels are decreased in septic patients. 

H22. Hesselvik, J. F., Blomback, M., Brodin, B., and Mailer R., Coagulation, fibrinolysis, and kallikrein systems in sepsis Relation to outcome. Crit. Care Med. 17,724-733 (1989). 

Volume 222. Proteolytic Enzymes in Coagulation, Fibrinolysis, and Complement Activation (Part A Mammalian Blood Coagulation Factors and Inhibitors)... 

Administration of activated protein C (drotrecogin) to promote fibrinolysis and associated antiinflammatory mechanisms may be beneficial in patients with an APACHE II (Acute Physiology and Chronic Health Evaluation II) score greater than 25. This agent reduced mortality in severe sepsis but poses an increased risk of serious bleeding. 

H11. Hajjar, K. A., Gavish, D., Breslow, J. L., and Nachman, R. L., Lipoprotein(a) modulation of endothelial cell surface fibrinolysis and its potential role in atherosclerosis. Nature (London) 339, 303-305 (1989). 

Modulates physiological processes such as cell adhesion and migration, fibrinolysis, and coagulation... 

Legnani C, Frascaro M, Guazzaloca G, Ludovici S, Cesarano G, Coccheri G. Effects of a dried garlic preparation on fibrinolysis and platelet aggregation in healthy subjects. Arzneimittel Forsch 1993 43 119-122. 

A related phenomenon is the repeat of a domain along the same polypeptide chain, as found in the immunoglobulins. Such repeats could have evolved by the fusion of two copies of the same gene. The proteases of coagulation, fibrinolysis, and complement activation appear to have arisen in a modular manner.31... 

Yasuda, S., Bohgaki, M., Atsumi, T., and T. Koike, 2005, Pathogenesis of antiphospholipid antibodies impairment of fibrinolysis and monocyte activation via die p38 mitogen-activated protein kinase pathway.Immunobiology. 210(10) 775-80. 

Id vivo, the infusion of small amounts of thrombin (<200 NIH-U/kg/h) causes defibrinogenation. Because of the slow transformation of fibrinogen, the fibrin monomers formed are eliminated via reactive fibrinolysis and RES without precipitation of fibrin. Upon infusion of higher amounts of thrombin, these clearance mechanisms fail bo offset the thrombin action, which then leads to the formation of microthmmbi in the peripheral circulation. Correspondingly, the bolus injection of 1500 NIH-U thrombin/kg caused death of the experimental... 

Egeblad K, Astrup T. Fibrinolysis and the trypsin inhibitor in human urine. Scand J Clin Lab Invest 1966 18 181-190. 

The significance of exon shuffling to protein evolution, in particular in respect to the development of multicellularity, is signified by a short inventory of processes involving proteins created by modular assembly. Exon shuffling facilitates the construction of proteins involved in regulation of blood coagulation, fibrinolysis, and complement activation, plus most constituents of the extracellular matrix, cell adhesion proteins, and receptor proteins [10, 57]. 

A large protein family that contains extracellular domains homologous to EGF is called the EGF-domain proteins. EGF-like domains or modules are often found in many extracellular and membrane proteins (>70). They are involved in blood coagulation, fibrinolysis and the complement systems, matrix proteins, cell surface receptors, the low-density hpoprotein receptor and the developmentally important receptor. Notch. EGF-like domains may exist as multiple copies within proteins such as in the Drosophila protein Notch with 36 copies or as a single copy as in EGF itself It can also be found in conjunction with other modules. 

Fibrinolysis and fibrinogenolysis in hver disease. Amer. J. Hematol. 1990 34 241-245... 

Thornes RD. Adjuvant therapy of cancer via the cellular immune mechanism or fibrin by induced fibrinolysis and oral anticoagulants. Cancer 1975 35(l) 91-7. 

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