Fertility Damage Effect

Carbon monoxide is also a well-known teratogenic compound for humans. The impact of carbon monoxide on the embryo or fetus is one reason for the developmental damage of smoking. 

Vitamin A, an essential vitamin, has an embryo or fetal toxicity for humans in higher amounts. Although a deficiency of this essential vitamin will lead to severe health effects, so also will an excess. Obviously two thresholds exist a lower threshold below which deficiency symptoms occur and an upper threshold above which there can be developmental defects. The concentration of vitamin A in food, including specific vitamin drinks, is usually well below any risk level. However, some medicines with high concentrations of vitamin A can activate embryo or fetal toxic effects. Therefore the instructions on the package have to be studied carefully  

Substances are classified as hazardous to fertility if they have disadvantageous effects on 

An effect harmful to fertility is only recognized if secondary effects can be excluded. For example, by causing increased stress it could change copulation behavior, or toxic effects at other organs could provoke an unusual attitude. 

It should be recognized that a third to a half of all fertilized human ova will not nidate in the uterus or will lead to a spontaneous miscarriage in the first three weeks of pregnancy. There can be many reasons for this, e. g., natural genetic defects. 

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A number of reproductive effects, including decreased fertility, damage to the gonads, and alterations in hormone levels, have been observed in male and female animals orally exposed to 2,3,7,8-TCDD. In male rats, a dose- and time-dependent reduction of serum testosterone and dihydrotestosterone levels was observed after acute oral exposure to 2,3,7,8-TCDD (Mebus et al. 1987 Moore et al. 1985, 1991). Furthermore, male rats had decreased weight of seminal vesicles following oral exposure to... 

It is possible to observe effects of organotin(lV) compounds exposure such as inhibition of cleavage of fertilized eggs, interference with the formation of the mitotic spindle, damages affecting chromosome structure, and electron-dense precipitate formation in organelles. 

Nitrogen oxides High-temperature reaction between atmospheric nitrogen and oxygen, e.g. during combustion Byproduct from manufacture of fertilizer Adverse health effects Sensory irritants Reduced visibility Crop damage... 

Fluorides Aluminium smelting Manufacture of ceramics, fertilizer Crop damage HF has adverse health effects on cattle fed on contaminated food... 

It is not known if 1,2-diphenylhydrazine would affect your health if were to breathe it in or eat it. The health effects of 1,2-diphenylhydrazine in humans have not been studied. Animals die if they swallow large amounts of 1,2-diphenylhydrazine and develop liver disease if hey eat small amounts of 1,2-diphenylhydrazine for more than a year. Therefore, it is possible that if you were to eat large amounts of 1,2-diphenylhydrazine for a long time you might experience liver damage or die It is not known whether 1,2-diphenylhydrazine would harm you if you were to spill it on your skin. It is not known ii 1,2-diphenylhydrazine causes birth detects or affects fertility. It is not known, if... 

Toxicity studies in animals have failed to show evidence of damage in any tissue examined after 3 months administration to rats of daily doses up to 20 000 times that required to produce diuresis. Similar absence of effect on all vital organs was found in dogs and rhesus monkeys. No teratogenesis or impairment of fertility was detected. Very large doses (up to 10 000 mg/kg) failed to produce ill-effects in acute toxicity tests on rats, though intravenous LDjo values were in the region of 230 mg/kg. 

The aims of testing for genotoxicity are, therefore, to assess the potential of a substance to be a genotoxic carcinogen, or to cause heritable damage in humans, which can be manifested as impaired male and/or female fertility, or adverse effects on fetal or postnatal development. 

A variety of reproductive effects including testicular effects, alterations in sexual behavior, and impaired fertility in females have been reported after high doses of chromium(VI) compounds." These effects, reproductive toxicity and testicular damage, were not replicated in a recent series of NTP studies in which mice and rats were exposed to 400 ppm in the diet." "... 

Sperm parameters abnormal sperm morphology Mating usually imaffected Fertility depending on magnitude and type of effect either imaffected, fecundity (number of offspring sired) reduced or males infertile may increase post-implantation loss if sperm DNA damage is present... 

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