Teratogenic compounds

More than 900 teratogens have been identified in experimental animals. However, only about 30 human teratogens have been identified. Human teratogens have been listed in Table 5.20. In this section, some of the best-known Teratogenic compounds are briefly described. 

The nature of the teratogenic compound or factor determines its access to the developing conceptus/tissue. 

Schmid BP, Trippmacher A, Bianchi A. 1982. Identification of teratogenic compounds using rodent embryos cultured during oraganogenesis in male rat serum. Teratology 25 22A. 

GH j-N+(0 )=N-CH2-0H), a DNA-damaging, genotoxic, mutagenic, toxic and teratogenic compound. 

Keeler RF, Binns W. Teratogenic compounds of Veratrum californicum (Durand). V. Comparison of cyclopian effects of steroidal alkaloids from the plant and structurally related compounds from other sources. Teratology. 1968 1(1) 5-10. 

Many possible alternative models have been explored during the last decades (e.g., whole rate embryo culture and primary or permanent embryonic stem cells54). Furthermore, different attempts have been made to develop QSAR approaches for the prediction of teratogenic effects.55-57 Fish embryos also appear to be a promising alternative test system for the reliable and cost-effective identification of potential human teratogenic compounds.58 An experimental advantage is their extracorporal development and the transparency of the eggs of... 

Examples of teratogenic compounds which interfere with nucleic acid metabolism are cytosine arabinoside, which inhibits DNA polymerase, mitomycin C, which causes cross-linking, and 6-... 

Teratogens Compounds that cause embryonic mortality or birth of offspring with physical, mental, or developmental defects. 

Carbon monoxide is also a well-known teratogenic compound for humans. The impact of carbon monoxide on the embryo or fetus is one reason for the developmental damage of smoking. 

Keeler, R. F. (1968). Teratogenic compounds of Veratrum califor-nlcum (Durand) IV. First isolation of veratramlne and alkaloid Q and a reliable method for isolation of cyclo-pamalne. Phytochemistry, 7 303-306. 

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