Executive responsibility meaning

When used judiciously, the advantages of QRA can outweigh the associated problems and costs. Companies that prudently commission QRAs and conscientiously act on the resulting recommendations are better off for two reasons (1) they have a better base of information to make decisions and (2) their judicious use of QRA technology represents another demonstration of responsible concern for the health and safety of workers and the public. However, companies should resist the indiscriminate use of QRA as a means to solve all problems since this strategy could waste safety improvement resources, diverting attention from other essential safety activities. Once executives are able to interpret and use QRA results, they will appreciate that the quality of their decisions rests largely on their ability to understand the salient analysis assumptions and the limitations of the results. 

An inventory management system should be established - meaning set up on a permanent basis to meet defined inventory policies and objectives approved by executive management. It should be documented - meaning that there should be a description of the system, how it works, the assignment of responsibilities, the codification of best practice, procedures, and instructions. The system should be planned, organized, and controlled in order that it achieves its purpose. A person should therefore be appointed with responsibility for the inventory management system and the responsibilities of those who work the system should be defined and documented. Records should be created and maintained that show how order quantities have been calculated in order that the calculations can be verified and repeated if necessary with new data. The records should also provide adequate data for continual improvement initiatives to be effective. 

Once the information is processed and yon (consciously or unconsciously) have decided what it means, yonr nervous system coordinates a response. This is the task of execution. The loop from sensation to processing to execution can occur at many levels. The simplest level is the reflex arc. As noted earlier, when your family doctor strikes your knee with a rubber hammer, the nerves at your knee sense the impact and transmit that information. This information is intercepted and processed well before it ever reaches your consciousness. A reflex center interprets the sensation as a possible threat and automatically executes a command to straighten your knee. The result is a reflex action that protects your leg from injury by kicking away the perceived threat. This sensation to processing to execution loop is completed without any involvement of yonr brain. 

Test immutable linking of electronic signatures to electronic records (including signatories printed names, execution time and date, and meaning of signature e.g., review, approval, responsibility, or authorship)... 

Sometimes interdepartmental roles and responsibilities for batch record development and review can become confused during the drive to bring a new product to the manufacturing floor. The information below intends to provide a guide for each department. Keep in mind that individual companies may have differences from what is written here therefore, it is imperative that these roles and responsibilities are included in SOPs dealing with batch record development, execution, and review. The goal is to make sure that all necessary steps, as listed in this chapter, are fulfilled. This list is by no means all inclusive of every department or of all actions necessary to meet specific internal requirements. 

The role of validation is to write and execute protocols to collect data and to verify that the process is repeatable and reproducible. It is not its responsibility to make the process work. The axiom of bad data in, bad data out is very pertinent to validation. Also bear in mind that just because the process in the batch record has been validated does not mean that a failure or deviation cannot occur during the execution of the batch record. It is not the FDA s belief that validation will prevent failures It is its belief that validation will show that a successful process can be repeated when key steps (as should be listed in the batch record) are repeated from batch to batch within a specified variation. Some key responsibilities for the validation group to consider... 

Extension of this theory can also be used for treating concentrated polymer solution response. In this case, the motion of, and drag on, a single bead is determined by the mean intermolecular force field. In either the dilute or concentrated solution cases, orientation distribution functions can be obtained that allow for the specification of the stress tensor field involved. For the concentrated spring-bead model, Bird et al. (46) point out that because of the proximity of the surrounding molecules (i.e., spring-beads), it is easier for the model molecule to move in the direction of the polymer chain backbone rather than perpendicular to it. In other words, the polymer finds itself executing a sort of a snake-like motion, called reptation (47), as shown in Fig. 3.8(b). 

Typing either the command "CTRL/P" or the command "P" in response to the query "PREVIEW, PLOT OR EXIT " will cause the execution of a peak picker. It works on the basis of determining the mean noise level of the data according to the equation... 

This tractability depends upon a rather unique and fortuitous combination of time constants which results in characteristic chemical response times being considerably shorter than dynamical time constants for many of the key mechanisms. Experimentally this means that pure chemical experiments can be executed in situ, to test photochemical hypotheses on the microscale within the atmosphere. On the other hand, dynamical experiments addressing the longer time scales can be conducted from Earth orbit via satellite to establish vertical and meridional transport maps. 

Site Audits. Regular site audits carried out on behalf of the Board of Executive Directors are an important means of answering questions regarding the success in implementing Responsible Care goals. These audits are essential for an assessment of the actual improvement with respect to the Responsible Care goals. They also contribute to the identification of areas with room for further improvement. 

The Biological Standards Act (1975) established the National Biological Standards Board. This Board, appointed by the UK health ministers and funded by the Health Department, is responsible for standards and control of biological substances, that is substances whose purity and potency cannot be adequately tested by chemical means, such as hormones, blood products and vaccines. The Board operates through the executive arm, the National Institute for Biological Standards and Control. 

The printed name of the signer the date and time when the signature was executed and the meaning (such as review, approval, responsibility, or authorship) associated with the signature. These items are subject to the same controls as for electronic records and shall be included as part of any human readable form of the electronic record (such as electronic display or printout). 

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