Excretory/secretory products

Mak, C.-H. and Ko, R.C. (1999) Characterization of endonuclease activity from excretory/secretory products of a parasitic nematode, TrichineUa spiralis. European foumal of Biochemistry 260, 477-481. 

Finally, several experiments indicate that excretory/secretory products (ESP), derived from newborn larvae or pepsin-HCl isolated mature muscle larvae, induce muscle cell basophilia (Blotna-Filipiak et al, 1998 Wranicz et al., 1998) or nuclear hypertrophy (Leung and Ko, 1997), respectively. Effects were observed in vivo and in vitro. Although correspondence of these general changes to biochemical or genomic characteristics of the infected cell and nuclei were not established, these observations may facilitate dissection of the parasite products that are responsible. 

Foster, N., Dean, E.J. and Lee, D.L. (1994) The effect of homogenates and excretory/secretory products of Nippostrongylus brasiliensis and of acetylcholinesterases on the amplitude and frequency of contraction of uninfected rat intestine in vitro. Parasitology 108, 453-459. 

Griffiths, G. and Pritchard, D.I. (1994) Purification and biochemical characterisation of acetylcholinesterase (AChE) from the excretory/secretory products of Trichostrongylus colubriformis. Parasitology 108, 579-586. 

Karanu, F.N., Rurangirwa, F.R., McGuire, T.C. and Jasmer, D.P. (1997b) Haemonchus contortus . inter- and intrageographic isolate heterogeneity of proteases in adult worm excretory-secretory products. Experimental Parasitology 86, 88-91. 

Britton, C., Canto, G.J., Urquhart, G.M. and Kennedy, M. (1993) Characterization of excretory-secretory products of adult Dictyocaulus viviparus and the antibody-response to them in infection and vaccination. Parasite Immunology 15,163-174. 

Harnett, W., Houston, KM., Amess, R. and Worms, M.J. (1993) Acanthocheilonema viteae. phosphorylcholine is attached to the major excretory-secretory product via a N-linked glycan. Experimental Parasitology 77, 498-502. 

Houston, K.M., Cushley, W.C. and Harnett, W. (1997) Studies on the site and mechanism of attachment of phosphorylcholine to a filarial excretory-secretory product. Journal of Biological Chemistry 272, 1527-1533. 

Harnett, W. and Harnett, M.M. (1993) Inhibition of murine B cell proliferation and down-regulation of protein kinase C levels by a phosphorylcholine-containing filarial excretory-secretory product. Journal of Immunology 151, 4829-4837. 

Harnett, W., Grainger, M., Kapil, A., Worms, M.J. and Parkhouse, R.M.E. (1989) Origin, kinetics of circulation and fate in vivo of the major excretory-secretory product of Acanthocheilonema viteae. Parasitology 99, 229-239. 

Segura M. Su Z. Piccirillo C. Stevenson MM Impairment of dendritic cell function by excretory-secretory products a potential mechanism for nematode-induced immunosuppression. 

Coustau, C., Mitta, G., Dissous, C., Guillou, F., Galinier, R., Allienne, J.F. and Modat, S. (2003) Schistosoma mansoni and Echinostoma caproni excretory-secretory products differentially affect gene expression in Biomphalaria glabrata embryonic cells. Parasitology 127, 533-542. 

Loker, E.S., Cimino, D.F. and Hertel, L.A. (1992) Excretory-secretory products of Echinostoma paraensei sporocysts mediate interference with Biomphalaria glabrata hemocyte functions. Journal of Parasitology 78, 104-115. 

Andersen, J.S. and Mann, M. (2000) Functional genomics by mass spectrometry. FEBS Letters 480, 25-31. Barrett, J., Jefferies, J.R. and Brophy, P.M. (2000) Parasite proteomics. Parasitology Today 16, 400-403. Bernal, D., de la Rubia, J.E., Carrasco-Abad, A.M., Toledo, R., Mas-Coma, S. and Marcilla, A. (2004) Identification of enolase as a plasminogen-binding protein in excretory-secretory products of Fasciola hepatica. FEBS Letters 563, 203-206. 

Jefferies, J.R., Campbell, A.M., Van Rossum, A.J., Barrett, J. and Brophy, P.M. (2001) Proteomic analysis of Fasciola hepatica excretory-secretory products. Proteomics 1, 1128-1132. 

Yoshino, T.P., Lodes, M.J., Rege, A.A. and Chappell, C.L. (1993) Proteinase activity in miracidia, transformation excretory-secretory products, and primary sporocysts of Schistosoma mansoni. Journal of Parasitology 79, 23-31. 

Ko RC, Ean L, Lee DL, Compton H (1994) Changes in host muscles induced by excretory/secretory products of larval Trichinella spiralis and Trichinella pseudospiralis. Parasitology 108 195-205 Kuratli S, Lindh JG, Gottstein B, Smith DP, Connolly B (1999) Trichinella spp differential expression of two genes in the muscle larva of encapsulating and nonencapsulating species. Exp Parasitol 93 153-159... 

Taenia crassiceps p66, an excretory/secretory product of the larva... 

Proteinases of all four major classes have been identified in helminths. Although there are few examples of aspartic proteinases, a number of cysteine, metallo- and serine proteinases have been well characterized. Many of those studied are excretory/secretory products and have attracted attention not only because of their likely biological function but also because they are major antigens which induce an easily detectable immune response. 

The molecule was first discovered as a 62 kDa foctor in excretory/secretory products (ES-62) of Acanthocheilonema viteae, a filarial nematode of rodents in 1989 by Harnett et ah It was also identified in other filarial nematode species that can cause severe human morbidity, such as Wuchereria bancrojii, Brugia malayi and Onchocerca volvulus. ES-62 is a phosphorylcholine (PC) containing glycoprotein that has been widely investigated as an immunomodulatory molecule. The active native molecule of ES-62 contains PC moieties that are modified by posttranslational processes. ... 

Bennett, S., and Fried, B. (1983). Densitometric thin-layer chromatographic analyses of free sterols in Echinostoma revolutum (Trematoda) adults and their excretory-secretory products. J. Parasitol. 69 789-790. 

Immunization induced protection must take into account the ability of L. cuprina to counteract host immunity. Excretory/secretory products of larvae reduce antibody responses 203) and secreted larval enzymes degrade C3 204) and IgG 205). 

MaeDonald M, Copeman DB, Harnett W (1996) Do excretory-secretory products of Onchocerca gibsoni contain phosphorylcholine attached to O-type gjycans Ini J Parasitol 26(10) 1075-80. 

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