N-linked glycans

Fig. 15.4 Structure of glycans N-linked to IgG molecules expressed in hybridomas and transgenic plants. Glycans N-linked to plant-derived antibodies are structurally different from their mammalian counterparts. In contrast with antibodies produced in alfalfa, antibodies produced in tobacco plants present a very high glycan heterogeneity.

EPO Tetraantennary complex type at three Asn sites and one O-linked glycans. More O-linked glycans and less sialic acid than native form manifest conformational differences and hence in the potency One O-linked and three N-linked glycans. N-linked glycans are extensively branched and complex type structure having tetraantennary glycans [212,215]... 

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