Evaluation automation

Currently, pathologists evaluate immunohistochemical or in situ hybridization studies. However, many groups are actively evaluating automated methods. The data extracted from the evaluation can be conveniently divided into two main areas quality control data and experimental data. Quality control data include information on the integrity of the core (e.g., presence/absence of tumor in the current section), as well as any internal controls that may relevant ... 

Ojanpera (1992) contributed a review with 55 references on toxicological drug screening by TLC. The article covers computerized system evaluation, automated sample application, instrumental modes of development, and computerized identification by use of values for numerous compounds. 

O leary, K., Budinski, M., and Lakshmanan, B. 2009. Methodologies for evaluating automative system contaminants. In Canada-USA PEM Network Research Workshop, Vancouver, Canada. 

Within the framework of the ANDES (Automatic Non-Destructive Evaluation System) at TNO Institute of Applied Physics two prototype applications have been developed for automated NDT data interpretation - both using the CBR methodology. 

Chan,R.W.Y., Hay,D.R., Matthews,J.R., MacDonald,H.A., (1988), Automated Ultrasonic System for Submarine Pressure Hull Inspection , Signal Processing and Pattern Recognition in Nondestructive Evaluation of Materials, C.H.Chen (ed). Springer-Verlag, pp. 175-187... 

During the past few years radioscopy has established itself in many fields that demand instant evaluation and a high degree of automation, as is the case in serial inspection. Furthermore, user experience has clearly shown that inspection costs can be considerably reduced by this technique. 

John F. Pautz and Klaus Abend "Automated particle testing" Materials evaluation, Vol. 54 / No. 9, Sept. 1996, pp. 1004-1008... 

The coin-tap test is a widely used teclinique on thin filament winded beams for detection of disbonded and delaminated areas. However, since the sensitivity of this teclinique depends not only on the operator but also on the thickness of the inspected component, the coin-tap testing technique is most sensitive to defects positioned near the surface of the laminate. Therefore, it was decided to constructed a new scaimer for automated ultrasonic inspection of filament winded beams. A complete test rig illustrated in figure 6 was constructed in order to reduce the scanning time. While the beam rotates the probe is moved from one end to the other of the beam. When the scarming is complete it is saved on diskette and can then be evaluated on a PC. The scanner is controlled by the P-scan system, which enables the results to be presented in three dimensions (Top, Side and End view). 

C, B K Shoichet and ID Kuntz 1992. Automated Docking with Grid-Based Energy Evaluation. mal of Computational Chemistry 13 505-524. 

Sucrose quantitation has also been performed by colorimetric methods. However, in recent years, automated enzymatic analyzers and instmmental methods (eg, ion chromatography and hplc) have become increasingly popular, as they provide greater sensitivity and accuracy. Near infrared (nir) spectroscopy is currendy under evaluation as a tool for sucrose quantitation in sugar mills and food processing operations. 

SPME has been utilized for deterrnination of pollutants in aqueous solution by the adsorption of analyte onto stationary-phase coated fused-siUca fibers, followed by thermal desorption in the injection system of a capillary gas chromatograph (34). EuU automation can be achieved using an autosampler. Eiber coated with 7- and 100-p.m film thickness and a nitrogen—phosphoms flame thermionic detector were used to evaluate the adsorption and desorption of four j -triazines. The gc peaks resulting from desorption of fibers were shown to be comparable to those obtained using manual injection. 

Catalyst testing and evaluation have been revolutionized by computers, automated test reactors, and analytical methods. With modem equipment, researchers can systematically prepare and screen many catalysts in a short time and efftciendy deterrnine, not only the initial catalytic activity and selectivity, but also the stabiUty and the appearance of trace products that may indicate some new catalytic properties worthy of further development. 

B. J. Ehrlich and S. E. Spencer, Development of an Automated Mustard S tack Monitor, Edgewood Arsenal Report No. ED-CR-76084, Tracer, Inc., June 1976. L. Schwart2 and co-workers. Evaluation of Ml 5/Ml 8 Enyme Detector Ticket System with Eow Concentration of GB, Edgewood Arsenal Report No. 

On-Hne Procedures The growing trend toward automation in industry has resiilted in many studies of rapid procedures for generating size information so that feedback loops can be instituted as an integral part of a process. Many of these techniques are modifications of more traditional methods. The problems associated with on-line methods include allocation and preparation of a representative sample analysis of the sample evaluation of the results. The interface between the measuring apparatus and the process has the potential of high complexity, and consequently, high costs [Leschonsld, Paiticle Cha racterization, 1, 1 (July 1984)]. 

N Srimvasan, TL Blundell. An evaluation of the performance of an automated procedure for comparative modelling of protein tertiary structure. Protein Eng 6 501-512, 1993. 

EC Meng, BK Shoichet, ID Kuntz. Automated docking with grid-based energy evaluation. J Comput Chem 13 505-524, 1992. 

TJA Ewing, ID Kuntz. Critical evaluation of search algorithms for automated molecular docking and database screening. J Comput Chem 18 1175-1189, 1997. 

Complete automation with computer control and on-line data evaluation and reduction is also possible (Dean and Angelo 1971, Gregory and Young 1979, Larmon et al 1981.)... 

Boyce, M.P., and Herrera, G., Health Evaluation of Turbine Engines Undergoing Automated FAA Type Cyclic Testing, Presented at the SAE International Ameritech 93, Costa Mesa, California, September 27-30, 1993, SAE Paper No. 932633. 

Automated Resource for Chemical Hazard Incident Evaluation... 

Today occupants, building owners, and other end users of ventilation systems are more interested in the level of air quality and thermal climate than in the techniques by which that level is achieved. This is supported by the fact that industrial ventilation system.s in modern premises are more complicated and tightly integrated with the process and building automation. It is therefore difficult for end users or nonprofessionals to evaluate whether a ventilation system is functioning correctly. 

Your procedures should detail your plant evaluation methods and require consideration to be given to the overall plan of the plant, automation, ergonomics, operator and line balance, inventory levels, and value added labor content. Reports of the evaluation should be required so that they facilitate analysis by management and auditors. 

Figure 15.11 (a) Total ion clnomatogram of a Grob test mixture obtained on an Rtx-1701 column, and (b) re-injection of the entire clnomatogram on to an Rtx-5 column. Peak identification is as follows a, 2,3-butanediol b, decane c, undecane d, 1-octanol e, nonanal f, 2,6-dimethylphenol g, 2-ethylhexanoic acid h, 2,6-dimethylaniline i, decanoic acid methyl ester ], dicyclohexylamine k, undecanoic acid, methyl ester 1, dodecanoic acid, methyl ester. Adapted from Journal of High Resolution Chromatography, 21, M. J. Tomlinson and C. L. Wilkins, Evaluation of a semi-automated multidimensional gas chromatography-infrared-mass specti ometry system for initant analysis , pp. 347-354, 1998, with permission from Wiley-VCH. 

M. J. Tomlinson and C. L. Wilkins, Evaluation of a semi-automated multidimensional gas chromatography-infared-mass spectrometry system for initant analysis , ]. High Resolut. Chromatogr. 21 347-354 (1998). 

Method development remains the most challenging aspect of chiral chromatographic analysis, and the need for rapid method development is particularly acute in the pharmaceutical industry. To complicate matters, even structurally similar compounds may not be resolved under the same chromatographic conditions, or even on the same CSP. Rapid column equilibration in SFC speeds the column screening process, and automated systems accommodating multiple CSPs and modifiers now permit unattended method optimization in SFC [36]. Because more compounds are likely to be resolved with a single set of parameters in SFC than in LC, the analyst stands a greater chance of success on the first try in SFC [37]. The increased resolution obtained in SFC may also reduce the number of columns that must be evaluated to achieve the desired separation. 

Ross A, Schlotterbeck G, Klaus W et al (2000) Automation of NMR measurements and data evaluation for systematically screening interactions of small molecules with target proteins. JBiomol NMR 16 139-146... 

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