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Etidronic acid

I>4 12440-00-5) see Etidronic acid l -tetrazol-5-carboxyiic acid 2-acetyi-6-(acetylamino)-phenyi ester... [Pg.2445]

EDTA Ethylenediamine tetraacetic acid ako known as etidronic acid EE Eosinophilic eosinophils EEG Electroencephalogram EET Epoxyeicosatrienoic acid EFA Essential fatty acid EFS Electrical field stimulation EGl Monoclonal antibody specific for the cleaved form of eosinophil cationic peptide... [Pg.281]

The highly polar clodronic acid (9.53, R, R = Cl), etidronic acid (9.53, R = Me, R = OH), and a number of analogues have demonstrated their clinical value in the treatment of osteoporosis, but they must often be administered by slow intravenous infusion due to their poor oral bioavailability. Esterification to orally available prodrugs is, thus, an actively investigated strategy. Promising results have, for example, been obtained with (pivaloyl-oxy)methyl esters of clodronic acid [120]. [Pg.581]

Agents include etidronic acid, pamidronic acid, clodronic acid, alendronic acid, ibandronic acid, rise-dronic acid, zoledronic acid and tiludronic acid. Formulations of clodronic acid and pamidronic acid are available for intravenous administration. The indications for the use of bisphosphonates include treatment of postmenopausal osteoporosis, hypercal-caemia of malignancy and Paget s disease. [Pg.399]

The three most commonly used phosphonates are diethylenetriaminepenta (methylenephosphonic acid) (DTPMP), ethylenediaminetetra(methylenephospho-nic acid) (EDTMP), and hydroxyethyldiphosphonic acid or etidronic acid (HEDP) (Figure 10.3). DTPMP and EDTMP are also powerful chelants that complex strongly with most metal ions to form six-coordinate complexes, and for this reason are often... [Pg.284]

O K 12440-00-5) sec Etidronic acid lff-tctrazol-5-carboxylic acid 2-acetyl-6-(acctylamino)-phenyl ester... [Pg.2445]

The first authentic synthesis of a bisphosphonic acid, l-hydroxyethane-l,l-bisphos-phonic acid (etidronic acid), was published by von Baeyer and Hofmann in 1897 [1], although it is possible that the same compound had already been obtained in 1865 by Menschutkin [2], The synthetic approach to BPs employed today differs only little from that used over a hundred years ago, and it is still based on the reaction of a carboxylic acid with phosphorus trichloride with the addition of some water [3], (Note BPs are usually represented as the free bisphosphonic acids the generic names given refer, however, to their salt forms.)... [Pg.371]

SYNS DEQUEST 2010 DEQUEST 2015 DEQUEST ZOlO EHDP ETHANE-l-HYDROXY-Ll-DIPHO-SPHONATE 1,1,1-ETHANETRIOLDIPHOSPHONATE ETIDRONIC ACID FERROFOS 510 HEDP 1-HYDROX -l,l-DIPHOSPHONOETHANE HYDROXY-ETHANEDIPHOSPHONIC ACID 1-HYDROXY-ETHANEDIPHOSPHONIC ACID OXYETHYL-IDENEDIPHOSPHONIC ACID PHOSPHONIC ACID, 1-HYDROX -l,l-ETHANEDIYL ESTER PHOSPHONIC ACID, (l-HYDROXYETHYLIDENE)BIS- lOOOSL TURPINAL SL... [Pg.754]

Most compounds in the study of Mallet et al. [102] respond similarly to the addition of acetic formic acid, although the effect is compound dependent. In negative-ion mode (Figure 6.5), most compounds are ion suppressed by formic and acetic acid additives. Anunoiuum hydroxide results in (significant) response enhancement for some compounds, e.g, raffinose, while the response of other compounds, e.g., malic acid and etidronic acid, is strongly suppressed. [Pg.163]

Figure 6.5 Effect of additives, formic acid (HCOOH), trifluoroacetic acid (TEA), ammonium hydroxide (NH40H), and acetic acid (AcOH) on the relative response of raffinose, etidronic acid, malic acid, and niflumic acid in ESI-MS (compared to 50% aqueous methanol, which is 100%). Data from [102],... Figure 6.5 Effect of additives, formic acid (HCOOH), trifluoroacetic acid (TEA), ammonium hydroxide (NH40H), and acetic acid (AcOH) on the relative response of raffinose, etidronic acid, malic acid, and niflumic acid in ESI-MS (compared to 50% aqueous methanol, which is 100%). Data from [102],...
Dunn, C.J. et al. (1994) Etidronic acid. A review of its pharmacological properties and therapeutic efficacy in resorptive bone disease. Drugs Aging, 5.446-474. Patel. S. (1996) Current and potential future drug treatments for osteoporosis. Ann. Rheum. Dis.. 55. 700-714. [Pg.63]

Unitex. [UPI] Propionic acid or salts or etidronic acid. [Pg.391]

EtidroniC Acid. (1 -Hytlroryctliyliden t liityiioi, phonic acid (l-bydroxyethylidene)diphosphonic acid ethane-1-hydroxy-1,1-dipbospbonic acid EHDP. C2H8-... [Pg.606]

Beilstein Handbook Reference) 1000SL Acetodiphosphonic acid Acide ebdronique Acido etidronico Acidum etidronicum Briquest ADPA-60A BRN 1789291 Dequest 2010 Dequest 2015 Dequest Z 010 Diphosphonafe (base) EHDP EINECS 220-552-8 Etidronic acid Etidronsaeure Ferrofos 510... [Pg.281]

Nitro DHPM 256 was synthesized through a modified Biginelli condensation involving cyclocondensation of ot-nitro acetophenone 255 with an aldehyde and urea in the presence of cone. HCl (Scheme 98, Method A) (06BMC1418) or etidronic acid in THE under microwave irridation (Method B, Scheme 98) (09MI3). [Pg.273]

Niemi R, Turhanen P, Vepsalainen J, Taipale H, Jarvinen T (2000) Bisphosphonate prodrugs synthesis and in vitro evaluation of alkyl and acyloxymethyl esters of etidronic acid as bioreversible prodrugs of etidronate. Eur J Pharm Sci 11 173-180... [Pg.149]

Acetodiphosphonic acid. See Etidronic acid Acetoglycerides. See Acetylated mono- and diglycerides of fatty acids Acetoin. See Acetyl methyl carbinol AcetomerTGIC. SeeTriglycidyl isocyanurate Acetomethoxan Acetomethoxane. See 6-Acetoxy-2,4-dimethyl-m-dioxane 1-Acetonaphthalene. See Methyl a-naphthyl ketone... [Pg.39]

Aqua ammonia Aqua ammonium. See Ammonium hydroxide Aquabon. See Chlorine dioxide Aquacei R-110-, Aquacei R-190. See Carboxymethylcellulose sodium Aquaceii. See Methylcellulose Aquachem 896. See Alkyd resin Aquacid-105 EX. See Etidronic acid Aquacid-106 EX. See Diethylene triamine pentamethylene phosphonic acid Aquacid-108 EX. See Ami noth methylene phosphonic acid... [Pg.332]

Aquanate 110. See Etidronic acid Aquanate 120. See Aminotrimethylene phosphonic acid... [Pg.333]

Belclene 660. See Etidronic acid Bellacide 325. See Terbuthylazine Bellasol S26 Bellasol S28. See Maleic anhydride, polymer with ethyl acrylate and vinyl acetate, hydrolyzed Bellasol S29. See Polyacrylic acid-co-hypophosphite, sodium salt Beisol. See Diisopropyl adipate Benacure 184. See 1-Hydroxycyclohexyl phenyl ketone... [Pg.414]

See other pages where Etidronic acid is mentioned: [Pg.807]    [Pg.2279]    [Pg.2424]    [Pg.2430]    [Pg.296]    [Pg.306]    [Pg.807]    [Pg.2279]    [Pg.2424]    [Pg.2430]    [Pg.523]    [Pg.523]    [Pg.1687]    [Pg.343]    [Pg.63]    [Pg.98]    [Pg.98]    [Pg.116]    [Pg.258]    [Pg.466]    [Pg.370]    [Pg.281]    [Pg.703]    [Pg.737]    [Pg.921]    [Pg.273]    [Pg.124]   
See also in sourсe #XX -- [ Pg.564 ]

See also in sourсe #XX -- [ Pg.387 ]

See also in sourсe #XX -- [ Pg.371 , Pg.373 , Pg.376 , Pg.380 , Pg.523 ]



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