Phosphorus trichloride, reaction with

Dimethylamine, reaction with phosphorus trichloride, 46, 42 f-Dimethylami nobenzaldehyde, conversion to 0,/9-dichloro- -dimethyl-aminostyrene, 46, 34 tn-Dimethylaminobenzoic acid, 47, 71 /5-Dimethylaminobenzoic acid, 47, 71 6.(Dimethylamino)fulvene, 47, 52 -Dimethylaminophenylacetic acid, 47, 71... 

Violent interactions occur with diselenium dichloride or disulfur dichloride, the latter emitting light and heat [1]. The very exothermic reaction with phosphorus trichloride may accelerate to explosion [2],... 

Chloro-1,3,2-oxazaphospholanc (chlorophosphoramidite) 43 derived from (IR, 25)-(-)-cphedrine 42 was prepared for the first time as early as 1977 by its reaction with phosphorus trichloride (Scheme 15) [32, 33], Later, similar procedures were reported for its isolation as a single epimer which, on the basis of spectroscopic and derivatisation studies, has been assigned configuration [34-36],... 

These materials, generally prepared from the corresponding Grignard reagents by the addition of cadmium chloride, provide a milder reagent system than the Grignard that allows selectivity in reaction with phosphorus trichloride (Equation 4.21).34-43-63... 

The lithium salt of a substituted cyclopentadienyl anion has been used in reaction with phosphorus trichloride for carbon-phosphorus bond formation.70 The resultant simple displacement product ultimately undergoes dimerization and loss of four (from the dimer) equivalents of HC1 (Equation 4.25). 

Reaction with phosphorus trichloride yields phosphorus trifluoride and with phosphoryl fluoride and sulfur trioxide, the product is phosphorus penta-fluoride ... 

Me CXMejSDP-PClj, reactions with lithium alkyls, 31 190-191 (Me,C)P(SiMe3)2 reaction with phosphorus trichloride, 31 189-190 MePfSiMejlj, reaction with phosphorus trichloride, 31 189-190 (MejSOjP-PiHl-PfSiMeOCMe, 31 191-192... 

The immediate use of the Grignard reagent thus obtained is imperative. If it is allowed to stand for any period of time, the yield in the subsequent reaction with phosphorus trichloride is reduced drastically. Furthermore, if formation of larger amounts of a white precipitate is observed at the end of the Grignard reaction, the reaction mixture should be discarded. 

Preparation of 4-cyanophenylzinc bromide by transmetallation and its reaction with phosphorus trichloride preparation of tris (4-cyanophenyl)phosphine-borane complex8... 

The Polish group28 have also isolated three new sulphoxides from Nuphar luteum. One alkaloid was a thiobinupharidine sulphoxide (37) and was converted into the parent base by reaction with phosphorus trichloride. The other sulphoxides (38), of which only one was isolated in the pure state, were epimeric reduction... 

A number of new sources of the known aspidospermidine derivatives (24-50) have been revealed in recent years 5,6,9,10,13,38,54-65,71,74-78) and are listed in Table 1. Fourteen new alkaloids have been isolated including (-i-)-l,2-didehydroaspidospermidine N-oxide (51), which is a constituent of the roots of R. stricta 66). Its structure was deduced from its spectroscopic properties, but an attempt to assign the absolute stereochemistry by removal of the A-oxide function by reduction or reaction with phosphorus trichloride met with failure, the product obtained being an unidentified indole derivative. 

Acid chlorides are made from fatty acids by reaction with phosphorus trichloride, phosphorus penta-chloride, phosphorus oxychloride, phosgene, oxalyl chloride, thionyl chloride or triphenylphosphine and carbon tetrachloride. Phosphorus trichloride is probably the most economical reagent for large-scale reaction. Improved yields have been claimed when the reaction is carried out in the absence of oxygen. The most common laboratory procedures require the acid to stand at room temperature for... 

Further studies by Spry (1975a,b) showed that treatment of the 3-formyl-2-cephem (247) with N-methylhydroxylamine gave the N-meth-ylnitrone (248). Sulfur oxidation and concomitant isomerization of the double bond then yielded the nitrone sulfoxide (249) which upon reaction with phosphorus trichloride in DMF, followed by ester cleavage, provided the 3-carboxamide-3-cephem-4-carboxylic acid (251). Alternatively, the reaction of the nitrone-2-cephem compound (248) with acetic anhydride furnished a mixture of the amide (250) and the imide (252). Both the amide and the imide, after isomerization of the double bond to 3-cephem and ester cleavage, gave the corresponding A -methylamide (251). 

Nevertheless, the possibility of modification of polysulfones main chains by Friedel-Crafts reaction with phosphorus trichloride and SnCU as a catalyst was demonstrated by Ziaja et al. [63]. 

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