Tiludronic acid

Sample preparation Mix 200 iaL plasma or urine with 400 aL 5 irg/mL IS in water, add 100 iaL 1 M NaOH, add 100 [aL 180 mM calcium chloride, add 1 mL water, vortex, centrifuge at 11600 g. Discard the hquid phase and dissolve the residue in 100 iL 1 M HCl, add 200 [jlL 1 M NaOH, add 100 aL 180 mM calcium chloride (only for plasma samples), add 1 mL water, vortex, centrifuge at 11600 g. Discard the hquid phase and vortex the residue with 200 [aL mobile phase containing 100 mM disodium EDTA until dissolution is complete, inject a 20-100 aL aliquot. 

Mobile phase MeCN buffer 13 87 (The buffer was 50 mM pH 11.8 disodium hydrogen phosphate containing 5 mM tetrabutylammonium phosphate.) 

Internal standard (3-trifluoromethyl)-thiomethylene bisphosphonic acid (4) 

Guyonnet, J. Berger, Y. Cautreels, W. Determination of (4-chlorophenyl)thiomethylene bisphosphonic acid, anew bisphosphonate, in biological fluids by high-performance hquid chromatography, 

---

Tablets 240 mg (equiv. to 200 mg tiludronic acid) Rx) Skelid (Sanofi-Synthelabo)... 

Tiludronate - Bioavailability is reduced by food. Tiludronic acid is... 

Agents include etidronic acid, pamidronic acid, clodronic acid, alendronic acid, ibandronic acid, rise-dronic acid, zoledronic acid and tiludronic acid. Formulations of clodronic acid and pamidronic acid are available for intravenous administration. The indications for the use of bisphosphonates include treatment of postmenopausal osteoporosis, hypercal-caemia of malignancy and Paget s disease. 

Pregnancy Category D (zoledronic acid) Category C (alendronate, oral and IV etidronate, pamidronate, risedronate, and tiludronate). 

Paget s disease Risedronate, pamidronate, alendronate, zoledronic acid, etidronate, tiludronate, and calcitonin surgery or bone replacement [10]... 

---