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Clodronic acid

The highly polar clodronic acid (9.53, R, R = Cl), etidronic acid (9.53, R = Me, R = OH), and a number of analogues have demonstrated their clinical value in the treatment of osteoporosis, but they must often be administered by slow intravenous infusion due to their poor oral bioavailability. Esterification to orally available prodrugs is, thus, an actively investigated strategy. Promising results have, for example, been obtained with (pivaloyl-oxy)methyl esters of clodronic acid [120]. [Pg.581]

R. Niemi, J. Vepsalainen, H. Taipale, T. Jarvinen, Bisphosphonate Prodrugs Synthesis and in vitro Evaluation of Novel Acyloxyalkyl Esters of Clodronic Acid , J. Med. Chem. 1999,42, 5053-5058. [Pg.603]

Agents include etidronic acid, pamidronic acid, clodronic acid, alendronic acid, ibandronic acid, rise-dronic acid, zoledronic acid and tiludronic acid. Formulations of clodronic acid and pamidronic acid are available for intravenous administration. The indications for the use of bisphosphonates include treatment of postmenopausal osteoporosis, hypercal-caemia of malignancy and Paget s disease. [Pg.399]

Clodronic acid disodium salt) Use calcium metabolism regulator... [Pg.513]

Ahlmark, M., Vepsaelaeinen, J., Taipale, H., Niemi, R., Jaervinen, T. Bisphophonate prodrugs synthesis and in vitro evaluation of novel clodronic acid dianhydrides as bioreversible prodrugs of clodronate. J. Med. Chem. 1999,42,1473-1476. [Pg.743]

Mixed anhydrides represent original attempts for preparing prodrugs of carboxylic or phosphonic acid. Clodronic acid dianhydrides (Fig. 33.7), for example, were shown to be novel bioreversible prodrugs of clodronate. They are more lipophilic than the parent clodronate, stable against chemical hydrolysis, and hydrolyse enzymatically to clodronate in human serum. ... [Pg.566]

Niemi R, Vepsalainen J, Taipale H, Jarvinen T (1999) Bisphosphonate prodrugs synthesis and in vitro evaluation of novel acyloxyalkyl esters of clodronic acid. J Med Chem 42 5053-5058... [Pg.148]

Finally, bisphosphonates have an important place in treatment of osteoporosis of all causes, including steroid-induced osteoporosis. Disodium etidronate, alendronate and clodronate all have potent effects to restore bone mass, and this effect persists for several years of therapy. Newer drugs such as zoledronic acid can be administered by infrequent (once-yearly) infusion, which can help compliance and reduce side effects. [Pg.777]

Bisphosphonates alendronate sodium clodronate disodium etidronate disodium pamidronate disodium risedronate sodium zoledronic acid... [Pg.606]

The treatment of Mrs CR s hypercalcaemia is urgent and requires immediate administration of bisphosphonate therapy, the first choice therapy in cases of severe hypercalcaemia. Currently four bisphosphonates are available in the UK for the treatment of malignant hypercalcaemia - sodium clodronate, disodium pamidronate, zoledronic acid and ibandronic acid. The choice of which bisphosphonate to recommend will depend on which one is on the local hospital formulary. [Pg.196]

Davies, F., Morgan, G., Wu, P., Gregory, W., Bell, S.E., Szubert, A., Navarro-Coy, N., Drayson, M., Owen, R.G., Feyler, S., Ashcroft, J., Ross, F., et al. (2011). Are there benefits to long-term bisphosphonate treatment in multiple myeloma (MM) Insights from temporal analyses of zoledronic acid (ZOL) versus clodronate (CLO) in the MRC Myeloma IX trial J Clin Oncol 29(Suppl.) abstr 8011, 506pp. [Pg.318]

Figure 14-7. Separation of organophosphonates and process-related impurities. Chromatographic conditions Hamilton PRP-XlOO, 250 x 4.6 mm, ImM trimesic acid (pH 5.5). 1, Phosphonopyrrolidine 2, alendronate 3,phosphite 4, chloride 5, methane-sulfonate 6, alendronate dimer 7, etidronate 8, clodronate. (Reprinted from reference 4, with permission.)... Figure 14-7. Separation of organophosphonates and process-related impurities. Chromatographic conditions Hamilton PRP-XlOO, 250 x 4.6 mm, ImM trimesic acid (pH 5.5). 1, Phosphonopyrrolidine 2, alendronate 3,phosphite 4, chloride 5, methane-sulfonate 6, alendronate dimer 7, etidronate 8, clodronate. (Reprinted from reference 4, with permission.)...
SYNS BM 06011 CHLODRONATE SODIUM CLODRONATE SODIUM DICHLOROMETHYD ENEDIPHOSPHONIC ACID DISODIUM SALT DICHLOROMETHANE DIPHOSPHONATE ... [Pg.1249]

DISODIUM CLODRONATE DISODIUM (DICHLOROMETHYLENE)BISPHOSPHONATE LODRONATE PHOSPHONIC ACID, (DICHLORO-METHYLENE)BIS-, DISODIUM SALT PHOSPHONIC ACID, (DICHLOROMETHYLENE)DI-, DISODIUM SALT... [Pg.1249]

Bisphosphonates (see later). Pamidronate is infused according to the schedule in Table 38.1 it is active in a wide variety of hypercalcaemic disorders. Fall in serum calcium begins in 1-2 d, reaches a nadir in 5-6 d and lasts 20-30 d. Etidronate may be given i.v. in hypercalcaemia of malignant disease. It acts in 1-2 d and a dose lasts 3 weeks it may also provide benefit for neoplastic metastatic disease in bone. Clodronate (oral or i.v.) or zoledonic acid (i.v) are alternatives. [Pg.740]

Abacavir Adinazolam 5-Aminosalicylic acid Atorvastatin Avitriptan Bromazepam Bumetanide Celecoxib CGP 43371 Clodronate Cyclosporin Danazol Didanosine Erythromycin Fexofenadine Furosemide Ganciclovir Halofantrine Inidnavir Itraconazole Levofloxacin Methotrexate Nifedipine Pravastatin Rifabutin Stavudine Tacrine... [Pg.2817]

Van Rooijen N, Sanders A (1996) Kupffer cell depletion by Hposome-deHvered drugs comparative activity of intracellular clodronate, propamidine and ethylenediaminetetraacetic acid (EDTA). Hepatology 23 1239... [Pg.201]

Clodronate Liposomal formulation CZE 1-Nitroso-2-naphthol-3,6-disulfonic acid disodium salt, pH 8.0... [Pg.359]

See other pages where Clodronic acid is mentioned: [Pg.513]    [Pg.374]    [Pg.52]    [Pg.53]    [Pg.79]    [Pg.169]    [Pg.258]    [Pg.726]    [Pg.132]    [Pg.726]    [Pg.66]    [Pg.513]    [Pg.374]    [Pg.52]    [Pg.53]    [Pg.79]    [Pg.169]    [Pg.258]    [Pg.726]    [Pg.132]    [Pg.726]    [Pg.66]    [Pg.374]    [Pg.256]    [Pg.510]    [Pg.336]    [Pg.198]    [Pg.776]    [Pg.381]    [Pg.304]    [Pg.716]    [Pg.548]    [Pg.553]    [Pg.934]    [Pg.158]    [Pg.257]   
See also in sourсe #XX -- [ Pg.564 ]

See also in sourсe #XX -- [ Pg.387 ]

See also in sourсe #XX -- [ Pg.374 , Pg.376 , Pg.380 ]



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Clodronate

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