2- - -ethylester

Malonsaure Nitroso- -1-cyclohexyl-amid-3-ethylester-l-imid El6a, 953 (CH -> C-NO)... 

Nitro-benzaldehyd kondensiert in Gegenwart von Piperidin mit l-Thiomalonsaure-3-O-ethylester-1 -O-isopropylester zu (4-Nitro-benzyliden)-l-thiomalonsaure-3-ethylester-l-0-isopropylester (85%)66,vs,a-67. Audi iiber die Michael-Additionen CH-adder Thiocarbonsaure-O-ester an Acrylnitril oder Acrylsaureester werden neue Thiocarbonsaure-O-ester zuganglich65,66 ... 

Dihydro-2//-pyran-5-carbaldehyde (7) was treated with sarcosine ethylester (2) in the presence of sodium ethoxide. What is the structure of the crystalline product Cii/7/rfN03 given its NMR spectra 27 ... 

In the course of synthesizing DNA-gyrase inhibitors Hogberg, Mitscher, and coworkers determined that an effective means of constructing the core of their inhibitors was via a K-R reaction. Under mild conditions, keto ethylester 52 was acylated using acetic formic anhydride in the presence of sodium formate to deliver chromone 53 in 75% yield. 

Free amino acids can be derivatized with isothiocyanates to phenyl- or methyl-thiohydantoin derivatives. The thiohydantoins can be separated on a CSP with poly-[Af-acryloyl-L-phenylalanine ethylester] (Chiraspher ) as a chiral selector [25]. This CSP offers a known selectivity for many five-membered heterocyclic rings. 

The open channel has in most cases a selective permeability, allowing a restricted class of ions to flow,for example Na+, K+, Ca++ or Cl- and, accordingly, these channels are called Na+-channels, K+-channels, Ca -channels and Cr-channels. In contrast, cation-permeable channels with little selectivity reject all anions but discriminate little among small cations. Little is known about the structures and functions of these non-selective cation channels [1], and so far only one of them, the nicotinic acetylcholine receptor (nAChR, see Nicotinic Receptors), has been characterized in depth [2, 3]. The nAChR is a ligand-gated channel (see below) that does not select well among cations the channel is even permeable to choline, glycine ethylester and tris buffer cations. A number of other plasma... 

Was prepd by Bailey and Knox (Ref 2) from benzenediazonium chloride and a-semicarbazino-propionic acid ethylester (Beil 4,557)... 

By this method, for example, the absolute configurations of the following compounds were established (-)-2-phenylbutyric acid,[48] (-)-hydratropic acid,[48] (+)-0-acetyl-mandelic acid,t48] (-)-2-(7/-carbazolyl)propionic acid,t48] (+)-1 -phenylethanol,[48] (-)-menthol,t48] (+)-1 -phenylethylamine,[48] and 1-alanine ethylester.[48] The determination of the absolute configuration of bacteriochlorophylles c, d and e was made possible by the esterification of the phaeophorbides by CDI to imidazolides.[49]... 

Apovincaminic acid ethylester was supplied by Richter Gedeon Co., (-)-dihydroapovincaminic acid ethyl ester was prepared according to the procedure described in (11). fSj-a, -diphcnyl-2-py rro 1 idincmethanol was synthesised as described (12). 2-benzylidene-l-benzosuberone was prepared as described in (13). Isophorone was supplied by Merck. Cinchonidine was purchased from Fluka. 

Methyl- branched Alkylester 7-Methyl-octanoate Heptanoate-7-methylester Octanoate-8-methylester Nonanoate-9-methylester Decanoate-10-methylester Heptanoate-7-ethylester Octanoate-8-ethylester Decanoate-10-ethylester Heptanoate-7-propylester Octanoate/7-methyl- octanoate Octanoate/octanoate-8-methylester or nonanoate-9-methylester or decano-ate-10-methylester or octanoate-8-ethylester or decanoate-10-ethylester Octanoate/5-me-thyl-octanoate or 6-methyl-octanoate ... 

A newer synthetic pathway, found by Lonza, involves chlorinating diketene to form the y-chloroacetoacetic ethylester, followed by condensation to afford the succinylosuccinic diethylester [5] ... 

Starting from 3-ethylamino-4-methylphenol, it is possible to synthesize the cation (133) by using phthalic anhydride, as described above, and forming the ethylester. The thus prepared product is the dye cation of Pigment Red 81. 

Fig. 8. Effect of linear flow velocity of an L-benzoyl arginine ethylester solution (0.2 mol/1) on the enzymatic activity of trypsin immobilized on poly(glycidyl methacrylate-co-ethylene dimethacrylate) beads (curve 1) and monolith (curve 2) (Reprinted with permission from [90]. Copyright 1996 Wiley-VCH). Reactor 50 mm x 8 mm i.d., temperature 25 °C...

Fig. 7.8. The hydrolytic metabolism of cocaine (7.57) to form benzoylecgonine (7.58), ecgo-nine methyl ester (7.59), and ecgonine (7.60). In the presence of ethanol, benzoylecgonine ethylester (7.61, cocaethylene) is also formed enzymatically as discussed in the text.

The variety of educts and products of the higher MCRs is illustrated here. Product 72 (Scheme 1.18) is formed from the five functional groups of lysine, benzaldehyde, and tert-butylisocyanide. The synthesis of 73 is achieved with hydrazine, furanaldehyde, malonic acid, and the isocyano methylester of acetic acid, compound 74 results from the reaction of benzylamine, 5-methyl-2-furanaldehyde, maleic acid mono-ethylester, and benzylisocyanide. ° Zhu et al. prepared a variety of related products, such as, 75, from (9-amino-methyl cinnamate, heptanal, and a-isocyano a-benzyl acetamides. 

Scheme 6.153 Proposed stereochemical model for the asymmetric addition of 1-methyleneaminopyrrolidine to aliphatic y.P-unsaturated a-keto ethylesters in the presence of catalyst 147.

FIGURE 2.10 Demonstration of shape influence on solute retention. Separation of fatty acid esters of identical chain length hut different position of double bonds. Column Prontosil SH 150x4mm mobile phase acetonitrile-water 9-1, v-v. Samples co3-docosa hexaenic acid ethylester (DHAEE) o)3-docosa pentaenic acid ethylester (DPAEE) o)6-docosa pentaenic acid ethylester. 

FIGURE 2.16 Influence of an organic modulator on selectivity. Comparison between acetonitrile and methanol. Isoelutropic conditions for ethyl benzene. Column Symmetry C8, 150 x4mm. Mobile phase methanol-water. 55-45, v-v. Acetonitrile-water, 42-58, v-v. Solntes 1, thiourea 2, aniline 3, phenol 4, o-toluidine 5, m-toluidine 6, -tolnidine 7, V,V-dimethyl aniline 8, benzoic acid ethylester 9, tolnene 10, ethyl benzene. 

Auch Ammoniumformiat wird gelegentlich als Ammoniak-Quelle verwendet. Dadurch gelingt bei der Umsetzung von 2-Chlor-3-oxo-3-phenyl-propansaure-ethylester mit Formamid zu 5(4)-Ethoxycarbonyl-4(5)-phenyl-imidazol (37%) in einer drucklosen Reaktion ebenfalls eine Sen-kung der Reaktionstemperatur auf 135°50,... 

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