Ethylene oxide respiratory system

Inhalation exposure to high concentrations of ethylene oxide has been reported to result in respiratory system irritation and edema (236). 

Toxicology. Ethylene oxide is an irritant of the eyes, respiratory tract, and skin at high concentrations it causes central nervous system depression it is carcinogenic in female mice. 

Toxicity of EtnO (Ref 17, pp 314—15 Spec MIL-E-52171). Liquid EtnO, concentrated or dilute, when exposed to the skin can cause -severe delayed bums. Short exposures produce mild first degree bums, but prolonged exposures produce second degree bums with the formation of large blisters. Exposure to the vapor results in systemic manifestations and irritation to the respiratory system. Inhalation of ethylene oxide vapors, if. prolonged, results in severe systemic poisoning with the symptoms of nausea, vomiting, headache, dysnea, and diarthea. The anesthetic properties are similar to chloroform, but with pronounced undesirable side and after effects. 

Different irritant chemicals affect parts of the mammalian respiratory system differently. The upper respiratory tract of the mammalian lung is affected by chemicals such as aldehydes, ammonia, alkaline dust, chromic acid, sulfur dioxide, sulfur trioxide, hydrogen fluoride, hydrogen chloride, and ethylene oxide). It is now known that many fluorine-containing organic compounds, such as chlorofluorocarbons (CFCs), have played a major role in the asthmatic deaths... 

Exposure to epoxides can cause irritation of the skin, eyes, and respiratory tract. Low-molecular-weight epoxides are strong irritants and more toxic than those of higher molecular weight. Inhalation can produce pulmonary edema and affect the lungs, central nervous system, and liver. Occupational exposure to ethylene oxide may cause axonal neuropathy... 

Ethylene oxide is a severe irritant, as well as a toxic and carcinogenic compound. Inhalation can cause severe irritation in the eyes, respiratory tract, and skin. In humans, the delayed symptoms may be nausea, vomiting, headache, dyspnea, pulmonary edema, weakness, and drowsiness. Exposure to high concentrations can cause central nervous system depression. 

Toxicology ACGIH TLV/TWA 2 mg(Sn)/m LD50 (IP, mouse) 101 mg/kg LC50 (inh., raL 10 min) 2300 m m poison by IP route mod. toxic by inh. conesive imtant to skin, eyes, mucous membranes causes bums imtating to respiratory system TSCA listed Precaution DOT Conesive material evolves heat on contact with moisture liberates HCI on contact with moisture or heat violent reaction with K, Na, turpentine, ethylene oxide, or alkyl nitrates Hazardous Decomp. Prods. Heated to decomp., emits toxic fumes of CL Storage Moisture-sensitive keep well stoppered Uses Electroconductive/electroluminescent coatings textile dye mordant ... 

Toxicity Ethylene oxide is a severe irritant to the eyes, skin, and respiratory tract and exhibits moderate acute toxicity by all routes of exposure. Symptoms of overexposure by inhalation may be delayed and can include nausea, vomiting, headache, drowsiness, and difficulty breathing. Ethylene oxide can cause serious bums to the skin, which may only appear after a delay of 1 to 5 hours. This substance may also be absorbed through the skin to cause the systemic effects listed above. Eye contact can result in severe bums. Ethylene oxide is not considered to have adequate warning properties. Ethylene oxide is listed by lARC in Group 2A ("probable human carcinogen") and is classified as a "select carcinogen" under the criteria of the OSHA Laboratory Standard. There is some evidence from animal studies that ethylene oxide may be a developmental and reproductive toxin in both males and females. Exposure to this substance may lead to sensitization. 

Ethylene oxide C2H4O 44.1 G Ether-like odor Ca [800] Eyes, skin, respiratory system, liver, centr nervous system, blood, kidneys, reproductive system... 

Synonyms Dimethylsiloxane-ethylene oxide block copolymer 2-[Melhoxy (polyelh-yleneoxy) propyl] heplamelhyltrisiloxane Poly [dimelhylsiloxane-co-melhyl (3-hydroxypropyl) siloxane-graft-poly (ethylene glycol) methyl ether Properties Sp.gr. 1.035 m.p. -14 C flash pt. > 109 C Toxicology Irritating to eyes, skin, respiratory system may be harmful by inh., ing., or skin absoq). 

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