3- Ethyl-4-methyl hexane

C8H18S tert-octyl mercaptan 141-59-3 1.386E-I-10 100.050 18193 C9H20 3-ethyl-4-methyl hexane 3074-77-9 1.388E+10 98.930... 

Ethyl-4-methyl hexane, ethyl Meat spoilage (aerobic bacteria. Pseudomonas... 

SO as to end the air mixture to adsorber No. 2. The system is then fully automatic. Solvents which have been successfully recovered by the activated carbon adsorption method include methanol, ethanol, butanol, chlorinated hydrocarbons including perchlorethylene, which boils at 121 C (250 °F), ethyl ether, isopropyl ether, the acetates up to amyl acetate, benzene, toluene, xylene, mineral spirits, naphtha, gasoline, acetone, methyl ethyl ketone, hexane, carbon disulfide, and others. 

Then, 1-(3-acetylthio-2-methylpropanoyl)-L-proline is produced. The 1-(3-acetylthio-3-methyl-propanoyl)-L-proline tert-butyl ester (7.8 g) is dissolved in a mixture of anisole (55 ml) and trifluoroacetic acid (110 ml). After one hour storage at room temperature the solvent Is removed in vacuo and the residue is precipitated several times from ether-hexane. The residue (6.8 g) is dissolved in acetonitrile (40 ml) and dicyclohexylamine (4.5 ml) is added. The crystalline salt is boiled with fresh acetonitrile (100 ml), chilled to room temperature and filtered, yield 3 g, MP 187°C to 188°C. This material is recrystallized from isopropanol [ttlo -67° (C 1.4, EtOH). The crystalline dicyclohexylamine salt is suspended in a mixture of 5% aqueous potassium bisulfate and ethyl acetate. The organic phase is washed with water and concentrated to dryness. The residue is crystallized from ethyl acetate-hexane to yield the 1-(3-acetylthio-2-D-methylpropanoyl-L-proline, MP83°Cto 85°C. 

It is well known that spontaneous resolution of a racemate may occur upon crystallization if a chiral molecule crystallizes as a conglomerate. With regard to sulphoxides, this phenomenon was observed for the first time in the case of methyl p-tolyl sulphoxide . The optical rotation of a partially resolved sulphoxide (via / -cyclodextrin inclusion complexes) was found to increase from [ajjgg = -H 11.5° (e.e. 8.1%) to Mjgg = -H 100.8 (e.e. 71.5%) after four fractional crystallizations from light petroleum ether. Later on, few optically active ketosulphoxides of low optical purity were converted into the pure enantiomers by fractional crystallization from ethyl ether-hexane . This resolution by crystallization was also successful for racemic benzyl p-tolyl sulphoxide and t-butyl phenyl sulphoxide L... 

S,5R)-1 -ethynyl-3,5-dihydroxy-2-methyl-l-cyclohexene (0.8215 mmol) anhydrous toluene (30 mL) dichloromethane ethyl acetate hexanes... 

A solution of 2.58 g (5.9 mmol) of (4-methoxyphenyl)methyl 6/J-benzylideneamino-6a-methylpenicillanate (2. R1 = C6H5 R2 = 4-CH3OC6H4CH2 R3 = CH3) in 75 mL of ethyl acetate is stirred at 20 C. 1.61 g (8.5 mmol) of 4-methyl benzenesulfonic acid and 1.61 mL(90 mmol) of water are added. A white solid starts to precipitate almost instantaneously. The reaction is allowed to proceed for 3 h before the white solid is filtered off and dried in vacuo to give 2.47 g (80%) of a salt. The latter is treated with aq NaHC03 to liberate the free amine which is recrystallized from ethyl acetate/hexane yield 1.33 g (65%) mp 84-87 °C. 

Fig. 12.1.1 Dependence of order parameter, S. of the secondary polymer, spin-labeled poly (methyl methacrylate) (PMMA) and polystyrene (PST), bound to poly(maleic anhydride—styrene )-grafted silica on hexane content in ethyl acetate-hexane cosolvent. Numbers in parentheses are number average molecular weight of the secondary polymer. (From Ref. 48.)...

After the autoclave was allowed to cool to room temperature, excess hydrogen was released carefully. The resulting mixture was evaporated, and the residue was purified by flash column chromatography over silica gel (eluent ethyl acetate/hexane= 1/20-1/5) to give (5)-3-methyl-A-(p-toluenesulfonyl)indoline... 

Methyl benzoylformate [15206-55-0] M 164.2, m 246-248°. Purified by radial chromatography (ethyl ether/hexane, 1 1), and dried at 110-112° at 6mm pressure. [Meyers and Oppenlaender JACS 108 1989 1986. ... 

Figure 4, Extractable organic profile (ethyl ether/hexane, 5/95) of a random lot of flexible PUF reconstructed ion chromatograms (GC-MS). A, solvent extract B, Soxhlet blank. Component identification (scan number, component) 232, phenol 391, hexanoic acid, 2-ethyl 490, 2,4- or 2,6-toluene diisocyanate (TDI) 507,2-propanamine, 2-methyl 592, phenol, 2,6-bis-(l,l-dimethylethyl)-4-methyl 696, chloroctane (isomer) 737, anthracene-dw (internal standard) 1047, isooctane, ethenyloxy. Continued on next page.

The alkane bears two methyl groups and an ethyl group. It is an ethyl dimethyl hexane. 

To the ketene silyl (thio)acetal (1 equiv.) was added at room temperature neat ethyl propynoate, dimethyl acetylenedicarboxylate or etliynyl methyl ketone (1 equiv.). The mixture was stirred for 5 h at room temperature. The volatile products were removed at room temperature in vacuo (0.1 Torr) for 30 min. Purification of the crude reaction mixture by silica gel column chromatography (ethyl acetate-hexane, 5 95) afforded cycloadducts. 

A mixture of substituted 2 -hydroxychalcone (1 mmol), the corresponding support (5 g) and the additive (5 mg) in a Pyrex tube was subjected to irradiation at 45 W for 20 min in a Maxidigest 350 Prolabo monomode, focused microwave (2.45 GHz) reactor with continuous rotation. The cooled mixture was washed with methylene chloride (2xl0mL) and concentrated in vacuo. The residue was purified by two subsequent column chromatographies (silica gel) by using hexane-acetone (4 1, v/v) and toluene or toluene-ethyl methyl ketone (30 1, v/v) as eluent. 

MAP (2,4-dinitrophenyl-(1)-alanine methyl ester) (44,45) is a comparatively older material which crystallizes on slow cooling from 34% ethyl acetate/hexane solutions over about three weeks as 0.2 cm3 monoclinic crystals (A = 6.829 A, b = 11.121 A, c = 8.116 A, b = 95.59°), mp 80.9° C. The yellow-orange crystals are transparent from about 500 nm to 2.0 11 at... 

To a solution of 2-iodo-5-(4-fluorophenylmethyl)thiophene (5.30 g, 16.6 mmol), in anhydrous DMF (5.0 ml) was added (R)-N-hydroxy-N-(3-butyn-2-yl)urea (2.12 g, 16.6 mmol), triphenylphosphine (84.0 mg, 0.32 mmol), bis(acetonitrile)palladium(II) chloride (40.0 mg, 0.16 mmol), copper(I) iodide (16.0 mg, 0.08 mmol), and diethylamine (5.6 ml). The mixture was stirred under nitrogen at room temperature for 22 h and concentrated in vacuum at 32°C. The residue was subjected to chromatography on silica eluting with 2-7% MeOH in CH2CI2, crystallization from ethyl acetate-hexane and trituration in CH2CI2 to afford (R)-N- 3-[5-(4-fluorophenylmethyl)thien-2-yl]-l-methyl-2-propynylVN-hydroxyurea as a cream-colored solid 0.94 g (18%), melting point 135°-136°C, (dec). 

To a suspension of 1 g of lithium aluminum hydride in 10 ml of anhydrous tetrahydrofuran cooled in an ice bath was added dropwise a solution of 1.94 g of methyl 3-methyl-trans-4a-cisoid-4a,5a-cis-5a-l,4a,5,5a,10b,10c-hexahydro-7-dioxino[5,4-a]cyclopenta[b]benzofurancarboxylate in 40 ml of anhydrous tetrahydrofuran. After being stirred for 30 min at room temperature, the reaction mixture was cooled in an ice bath. The excess of lithium aluminum hydride was decomposed by the addition of ethyl acetate, and aqueous saturated solution of potassium sodium tartarate was added to the reaction mixture. After filtration of the mixture, the filtrate was concentrated and the residue was dissolved in 10 ml of methanol. After addition of 2 g of potassium carbonate to the solution, the mixture was stirred for 3 hours at room temperature and was concentrated. After water was added to the residue, the aqueous mixture was extracted 3 times with ethyl acetate. The combined organic layers were washed with water and saturated aqueous solution of sodium chloride, dried, and concentrated to give 2 g of crude crystals. The crude crystals were recrystallized from ethyl acetate-hexane to yield 1.49 g of the pure crystals of the titled compound (m.p. 124-125°C, yield 85%). 

To a solution of the N-methoxy-N-methyl-2,8-bis(trifluoromethyl)-quinoline-4-carboxamide amide (10 g, 28.4 mmol) in anhydrous ether (100 ml) was added a solution of 2-pyridyl lithium (Pinder et al (J. Med. Chem. 1968, 11, 267)) [formed by addition of 2-bromopyridine (3.3 ml, 34.6 mmol) to a solution of butyl lithium (29.7 ml of a commercial 1.6 M solution, diluted with an equal quantity of ether) at -78°C] at -78°C. Analysis of the reaction by TLC after 10 min showed that no starting material remained. The reaction was allowed to warm to room temperature, then poured into aqueous ammonium acetate, and extracted with ether, the combined organic layers washed with brine and dried (MgS04). Filtration through a pad of silica gel using ethyl acetate-hexane (1 1) afforded 9.0 g (84%) of the crude 2,8-bis(trifluoromethyl)-4-quinolinyl-2-pyridinylmethanone. This was recrystallised from isopropyl alcohol to give the product as colourless needles, identical to that described in the literature (Hickmann et al. Pinder et al. Ohnmacht et al. and Adam et al. (Tetrahedron 1991, 36, 7609)). 

To a 2 L, 3-neck Morton flask fitted with a thermometer, a mechanical stirrer, and an addition funnel was added the methyl 3-hydroxy-2-methylene-3-phenylpropionate (305.9 g, 1.585 mol) followed by addition of 48% HBr (505 ml, 4.46 mol) in one portion. The flask was immersed in an ice-water bath, at which time concentrated sulfuric acid (460 ml, 8.62 mol) was added dropwise over 90 min and the internal temperature of the reaction mixture was maintained at 23°-27°C throughout the addition process. After removal of the ice-water bath, the mixture was allowed to stir at room temperature overnight. The solution was then transferred to a separatory funnel and the organic layer was allowed to separate from the acid layer. The acids were drained and the organic layer was diluted with 2 L of a 1 1 ethyl acetate/hexane solution, washed with saturated aqueous sodium bicarbonate solution (1 L), dried over sodium sulfate, and concentrated to yield 400.0 g (99%) of the desired (Z)-l-bromo-2-carbomethoxy-3-phenyl-2-propene as a light yellow oil, which was used without any additional purification, boiling point 180°C (12 mm). 

The 2,2-dimethyl-5-chloro-2,3-dihydrobenzofuran-7-carboxylic acid, methyl ester were heated at reflux with sodium hydroxide and water for 2-3 h. After cooling, the mixture was extracted with diethyl ether and ethyl acetate. The aqueous layer was acidified with hydrochloric acid and again extracted with ethyl acetate and diethyl ether. These latter organic extracts were combined and washed with water, dried over sodium sulfate, and concentrated in vacuum. Crystallization of the resulting solid from ethyl acetate/hexane provided the desired 2,2-dimethyl-5-chloro-2,3-dihydrobenzofuran-7-carboxylic acid, 71% yield, melting point 158.5°-160°C. 

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