Flasks Morton

A significant advance was made in this field by Watarai and Freiser [58], who developed a high-speed automatic system for solvent extraction kinetic studies. The extraction vessel was a 200 mL Morton flask fitted with a high speed stirrer (0-20,000 rpm) and a teflon phase separator. The mass transport rates generated with this approach were considered to be sufficiently high to effectively outrun the kinetics of the chemical processes of interest. With the aid of the separator, the bulk organic phase was cleanly separated from a fine dispersion of the two phases in the flask, circulated through a spectrophotometric flow cell, and returned to the reaction vessel. 

Use of a Morton flask and an overhead stirrer allows for better mixing of the two-phase system and gives conversion to product faster than does use of a standard round-bottomed flask with an overhead stirrer. 

Connect a dry 100-ml Morton creased flask with a three-necked opening to a septum, condenser, and thermometer. Add a glass-encased magnetic stirring bar. 

A. 2-Cyanoethylthiouronium hydrochloride (3). To a 5-L, flanged-top, spherical Morton flask equipped with a supporting clamp (Note 1) are added water (380 mL), thiourea (575 g, 7.53 mol), and 3-chloropropionitrile (500 g, 5.58 mol) (Note 2). The flask is equipped with a three-necked (with thermometer inlet) flanged-top, mechanical stirring rod (600 mm) with Teflon paddle (110 mm), temperature probe, reflux condenser, gas bubbler, and 5-L heating mantle. The reaction mixture is slowly... 

The reaction can be carried out in a normal three-necked 5-L Morton flask. However, product 3 will solidify in the flask making its removal from a three-necked flask tedious. The submitter s experience has shown that use of an open top reactor-... 

A creased or Morton flask was preferable as the rate of hydrolysis of the chloroacetate increases with efficient agitation. 

Method A. Enantiomerically pure ethyl (R-)2-fluorohexanoate (60% hydrolysis). A 1-L Morton flask equipped with a mechanical stirrer, glass baffle, an electrode connected to a pH control unit and an addition tube connected to a syringe pump, is charged with 300 mL of 0.05 M aqueous phosphate buffer (pH 7.0) (Fisher), 300 mL of deionized water, and 70 g (0.43 mol) of ethyl 2-fluorohexanoate. The resulting mixture is stirred for several minutes and the pH is adjusted to 7.0 with the addition of a few... 

C. (+)-(2R,8aS)-10-(Camphorylsulfonyl)oxaziridine. A 5-L, three-necked, round-bottomed Morton flask is equipped with an efficient mechanical stirrer, a 125-mm Teflon stirring blade, a Safe Lab stirring bearing (Note 6), and a 500-mL addition... 

If the reaction mixture takes on a brownish color after addition of oxone and has not gone to completion after 30 min, the reaction mixture is filtered through a 150-mL sintered glass funnel of coarse porosity, and the solids are washed with 50 mL of methylene chloride. The aqueous/organic extracts are returned to the 5-L Morton flask, stirred vigorously and 52 g (0.08 mol, 1 equiv KHSO5) of oxone is added over 5 min and stirring continued until oxidation is complete (approximately 10-15 min). 

A. 3-Methylcyclohexanone-3-acetic acid. A 2-L, three-necked Morton flask fitted with a low-temperature thermometer, 250-mL addition funnel, an exit tube attached to a calcium chloride drying tube, and a Teflon-coated magnetic stirring bar, is charged with 1.1 L of anhydrous ethanol. The stirred solution is cooled to 0°C and... 

If the small proportion of acetone present in synthetic methanol is objectionable it may be removed when present in quantities up to 1 per cent by the following procedure (Morton and Mark, 1934). A mixture of 500 ml of methanol, 25 ml of furfural and 60 ml of 10 per cent sodium hydroxide solution is refluxed in a 2-litre round-bottomed flask, fitted with a double surface condenser, for 6-12 hours. A resin is formed which carries down all the acetone present. The alcohol is then fractionated through an efficient column, the first 5 ml which may contain a trace of formaldehyde being rejected. The recovery of methanol is about 95 per cent. 

Several types of equipment were used to prepare the latexes. A five gallon glass reactor, five and two liter Morton flasks equipped with condensers, stainless steel stirrers, thermoregulators, and nitrogen inlets were used to prepare the seed latexes... 

To a 2 L, 3-neck Morton flask fitted with a thermometer, a mechanical stirrer, and an addition funnel was added the methyl 3-hydroxy-2-methylene-3-phenylpropionate (305.9 g, 1.585 mol) followed by addition of 48% HBr (505 ml, 4.46 mol) in one portion. The flask was immersed in an ice-water bath, at which time concentrated sulfuric acid (460 ml, 8.62 mol) was added dropwise over 90 min and the internal temperature of the reaction mixture was maintained at 23°-27°C throughout the addition process. After removal of the ice-water bath, the mixture was allowed to stir at room temperature overnight. The solution was then transferred to a separatory funnel and the organic layer was allowed to separate from the acid layer. The acids were drained and the organic layer was diluted with 2 L of a 1 1 ethyl acetate/hexane solution, washed with saturated aqueous sodium bicarbonate solution (1 L), dried over sodium sulfate, and concentrated to yield 400.0 g (99%) of the desired (Z)-l-bromo-2-carbomethoxy-3-phenyl-2-propene as a light yellow oil, which was used without any additional purification, boiling point 180°C (12 mm). 

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