Ethyl methanesulphonate

ETHYL METHANESULFONATE see EMF500 ETHYL METHANESULPHONATE see EMF500 ETHYL METHANOATE see EKLOOO ETHYL METHANSULFONATE see EMF500 ETHYL METHANSULPHONATE see EMF500 ETHYL-4-METHOXYBENZOATE see AOVOOO ETHYL-p-METHOXYBENZOATE see AOVOOO ETHYL-2-METHYLACRYLATE see EMFOOO... 

O Donovan MR. 1990. Mutation assays of ethyl methanesulphonate, benzidine and benzo[a]pyrene using Chinese hamster V79 cells. Mutagenesis 5 9-13. 

Pyrolysis of isochromanones in the gas phase at 500 °C, with resultant loss of carbon dioxide, has afforded a new synthesis of 4,5-dimethoxy-, 4,5-methylenedioxy-, and 4-methoxy-benzocyclobutene. Photosolvolysis of 2-(3,5-dimethoxyphenyl)ethyl methanesulphonate in 50% aqueous methanol gave inter alia small amounts of 3,5-dimethoxybenzocyclobutene. 

Pre-treatment of rat hepatocytes with a-toco-pheryl succinate dramatically emiched cells and mitochondria with a-tocopherol and provided these membranes with complete protection against ethyl methanesulphonate-induced oxidative damage (Zhang etal. 2001). a-Tocopherol pre-treatment suppressed ethyl methanesulphonate-induced cellular production of reactive oxygen species, generated from mitochondrial complex I and III sites. 

For ethyl methanesulphonate- and Fe -treated rat hepatocytes, the in vivo pretreatment with u-a-tocopherol offered no protection against cell death and lipid peroxidation over a 6 h incubation period (Fariss et al. 2001). In contrast, hepatocytes isolated from rats treated with u-a-tocopheryl succinate were completely protected against ethyl methanesulphonate-induced lipid peroxidation for the entire incubation period, which also resulted in dramatic protection against ethyl methanesulphonate-induced cell death. Similarly, n-a-tocopheryl succinate administration in vivo dramatically protected isolated hepatocytes against Fe-induced cell... 

J. Cole and C. F. Arlett, Ethyl methanesulphonate mutagenesis with L5178Y mouse lymphoma cells A comparison of ouabain, thioguanine and excess thymidine resistance, Mutat. Res. 34, 507 (1976). 

Alpha-linolenic acid( 18 3) content is particularly high in linseed oil (45-65 ). However, following EMS (ethyl methanesulphonate) mutagenesis of linseed (cv. Glenelg) two mutant lines, M1589 and 111722 were isolated which had a 30 - 40 reduction in linolenate content in their seed oils [ 1 ]. 8y recombination of the two mutant lines a genotype was obtained with a near zero (<2 ) linolenic acid level in the seed oil (2) referred to as "Zero . Only the ratio of linoleate (18 2) to linolenate was affected in the mutant lines which thus had normal content of the other fatty acids in their seeds. It was further shown that the two mutations exhibited codominant gene action and were on separate chromosomes 13). 

The kinetics of quaternization of pyridine with ethyl methanesulphonate in water 246a and with ethyl iodide in nitrobenzene 246 have been studied. 

NG = N-Methyl-N -NitrO N Nitrosoguanidine, MNU = N-Methyl-Nitroso-urea,EMS = Ethyl methanesulphonate, AcDMN =Acetoxydimethylnitros-amine, NM = Nitrosomorpholine, NP = Nitrosopyrrolidine. 

Brooks, T.M. Dean, S.W. (1997) The detection of gene mutation in the tubular sperm of Muta Mice following a single intraperitoneal treatment with methyl methanesulphonate or ethyl-nitrosourea. Mutat. Res., 388, 219-222... 

A solution of l-(4-aminophenoxy)-2-[N-(4-aminophenethyl)-N-methylamino]ethane (0.75 g) and methanesulphonic anhdyride (1.0 g) in dry methylene chloride (50 ml) was stirred at room temperature overnight. After evaporation, the resultant oil was partitioned between a 2 N aqueous sodium bicarbonate solution and ethyl acetate. After two further extractions with ethyl acetate, the organic portions were combined, dried over magnesium sulfate, filtered and evaporated. The resultant colourless solid (1.2 g) was crystallised from ethyl acetate/methanol to give methanesulfonamide, N-(4-(2-(methyl(2-(4-((methylsulfonyl)amino)phenoxy)ethyl)amino)ethyl)phenyl)-, (0.6 g), m.p. 147-149°C. 

Reactions of 3-substituted 2-(lV-phenylaminomethyl)piperazines with a slight excess of ethyl 2-chloroacetate under reflux afforded mixtures of 9-substituted 2-phenylperhydropyrido[l,2-a]pyrazin-3- and -4-ones, which could be separated by column chromatography [72JCS(P2)1374], When 2-[(3-trifluoromethylphenyl)aminomethyl]piperidine was heated with optically active ethyl 2-chloropropionate (87MIP1 91TA231), or lactic acid ethyl ester methanesulphonate (91TA231), the product was a C-9a epimeric mixture of 2-(3-trifluoromethylphenyl)-4-methylperhydropyrido[l,2-fl]-pyrazin-3-ones. The reaction between yV-methyl-2-piperidine-carboxamide and hydroxymaleic anhydride in pyridine resulted in 2,3-dimethyl-3-hydroxyperhydropyrido[l,2-a]pyrazine-l,4-dione (74CB2804). 

Methyl methanesulphonate, ethyl methanesulfonate, ethylnitrosurea, mitomycin, or 4-nitroquinone-A-oxide for the nonmetabolic activation and benzo(a)pyrene or cyclophosphamide for the metabolic activation... 

CHLOROETHYLMETHANESULFONATE CHLOROETHYL METHANESULPHONATE CHLORO-METHANE SULFONATE d ETHYLE (TRENCH) METHANESULFONIC ACID CHLOROETHYL ESTER NSC-18016... 

E 9 mM methanesulphonic acid + 0.7% methyl ethyl ketone F 1 mPmin... 

Anantharaj R, Banerjee T (2013) Thermodynamic properties of l-ethyl-3-methylimi-dazolium methanesulphonate with aromatic sulphur, nitrogen compounds at T = 298.15-323.15 K and P = 1 bar. Can J Chem Eng 97 245-256... 

TLC-UAD, benzene ethyl acetate as eluent LC-UVA IS, Ph column at 40°C with gradient MeCN 5 mM methanesulphonic acidiacetate buffer pH 4.2... 

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