Gene action

AA biosynthesis. At an ever deeper level it is possible that high concentrations of the product AA can inhibit expression of the gene for formation of the RNA needed for enzyme synthesis. This form of suppression of gene action over many generations could lead to loss of the gene, causing the AA to become an essential amino acid. 

Silvers, W. K. (1979). The Coat Colors of Mice—A Model for Mammalian Gene Action and Interaction. Springer, New York. 

Gene Expression The phenotypic manifestation of a gene or genes by the processes of gene action. [NIH]... 

Reddy GM, Coe EH Jr (1962) Inter-tissue complementation a simple technique for direct analysis of gene-action sequence. Science 138(3537) 149-150... 

M2a. Marks, P. A., Gross, R. T., and Hurwitz, R. E., Gene action in erythrocyte deficiency of glucose-6-phosphate dehydrogenase Tissue-enzyme levels. Nature (.London) 183, 1266-1267 (1959). 

Wallace, Bruce, and Joseph O, Falkinham. 1997. The Study of Gene Action. Ithaca, N.Y. Cornell University Press,... 

Lyon MF. 1961. Gene action in the X-chromosome of the mouse (MusmusculusL.). Naturwissenschaften 190 372-373. 

The second major breakthrough was discovered by Beadle and Tatum (1941) with their conceptual one-gene-one-enzyme hypothesis. This proved the biochemical basis for the mechanism of gene action and integrated... 

Ekker, S.C., von Kessler, D.P., Beachy, P.A. 1992. Differential DNA sequence recognition is a determinant of specificity in homeotic gene action. EMBO J. 11, 4059-4072. 

The decrease in the NADP-GDH activity with exogenous supplements like urea reflects repression of gene action rather than enzyme inhibition (166,169). The am designation is used for the locus specifying NADP-GDH, and the synthesis of the corresponding inactive proteins (CRM) by am (amination-deficient) mutants can be regulated by urea in the... 

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