2-Amino-l-phenoxy

Another alternate pathway for the synthesis of racemate product (6) is shown in Scheme 2 [6]. l-phenoxy-2-bromopropane (8) was obtained in 38% yield by the bromination of 1-phenoxy-2-propanol (7) with PBr3. Compound (8) was refluxed in butanol with l-(4-hydroxyphenyl)-2-amino-1-propanol (9) to yield racemate product (6). 

Pyridinium 2-Amino-l-[(2-brom-phenoxy)-methyl]- -chlorid E14a/2, 779 (Pyridinium-Bild.)... 

Propan 2-(N-Chloracetyl-methyl-amino)-l-phenoxy- XI/2, 35 Pyridin-l-oxid 4-Chlor-2-(l-hydroxy-cyclohexyl)-3-methyl-E19d, 605 (H -> Li/+ Keton)... 

Trost and coworkers developed a chiral zinc phenoxide for the asymmetric aldol reaction of acetophenone or hydroxyacetophenone with aldehydes (equations 62 and 63) . This method does not involve the prior activation of the carbonyls to silyl enol ethers as in the Mukaiyama aldol reactions. Shibasaki and coworkers employed titanium phenoxide derived from a phenoxy sugar for the asymmetric cyanosilylation of ketones (equation 64). 2-Hydroxy-2 -amino-l,l -binaphthyl was employed in the asymmetric carbonyl addition of diethylzinc , and a 2 -mercapto derivative in the asymmetric reduction of ketones and carbonyl allylation using allyltin ° . ... 

Nitro-l-methylthio- 684 Nitro-thiocyanat- 635 2-Nitro-l-thiocyanat- 680, 692 4-Nitro-l-thiocyanat- 685, 687 2-Nitro-l-[penten-(l)-yl-(2)]- 698 4-Nitro-l-phenoxy- 688 4-Nitro-l-phenylthio- 684 2-Nitro-l-piperidino- 696 2-Nitro-l-(propyl-butyl-amino)- 696 Nitro-seleno- 558... 

CN ( )-l-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]-3-[(l-methylethyl)amino]-2-propanol hydrochloride... 

CN 1 - [(1,1 -dimethy lethy l)amino]-3- [2- [(tetrahydro-2-furanyl)methoxy ]phenoxy ]-2-propanol... 

The condensed reaction mixture is evaporated in film evaporator 16 under vacuum. The crude l-(2,6-dimethyl)-phenoxy-2-aminopropane hydrochloride is precipitated in tank 17 using HCl dissolved in organic solvent //, separated in centrifuge 18, and dried in tray drier 19. The final purification by crystallization from solvent III occurs in crystallizer M. Pure l-(2,6-dimethyI)-phenoxy-2-amino-propane hydrochloride is separated in centrifuge 21 and dried in tray drier 22. The plant is equipped with typical solvent recovery and storage facilities not shown in the figures. 

GFP hopo ICBP IP3 Ln3+ mal memal MLCK nota oxine par pdta pmea py quin-2 green fluorescent protein hydroxypyridinon(at)e intestinal calcium-binding protein inositol 1,4,5-triphosphate a lanthanide(III) cation malonate methylmalonate myosin light chain kinase 1,4,7-triazacyclononane-l,4,7-triacetate 8- hydroxyquinoline pyridine-2-azo-4 -dimethylaniline propylene-1,2-diaminetetraacetate 9- [2-(phosphonomethoxy)ethyl] adenine pjrridine pjrridyl 8-amino-2- [(2-amino-5-methylphenoxy )methyl] -6-methoxyquinoline-ATJV -tetraacetate 2- [ [2-[his(carboxymethyl)amino]-5-methyl-phenoxy] methyl] -6-methoxy-8- [bis(carboxymethyl) amino] quinoline]... 

Amino-5-[3-(3-piperidinomethyl-phenoxy)-propylamino]-l,3,4-oxadiazol416 reagiert in Methanol mit waBrigem Ammoniak unter Ringoffnung zu l-[3-(3-Piperidinomethyl-phenoxy)-pro-pylaminocarbonyl]-2-(imino-methoxy-methyl)-hydrazin12S (40% Ol). 

H5C ° V An/NH2 Y H CHj 1. HCl/HaO/Etber dann NaN02, 0°, 15 min 2. filtriete Losung + Toluol eindampfen 3. Rlickstand/Toluol/HCI/ HjO, SO1 dann Riickfl. 18 h 4. NaOH/HzO l-Amino-2-methyl-3-phenoxy- cyclopropan 19 4... 

Oxidation of 3-methoxy- or 3-phenoxy-1,2,4-triazines (228) with perbenzoic acid converted them into the appropriate 1-oxides (229) (71JOC787). Peracid treatment of 1,2,4-triazin-3-ones with an unsubstituted 5-position (84 R5 = H) gave l,2,4-triazine-3,5-diones (182) (69JHC403), while 5-substituted l,2,4-triazin-3-ones (84) afforded the appropriate 1-oxides (230) (66JOC3914). 3-Amino-l,2,4-triazines with an unsubstituted (86a) or a monosubstituted amino group (86b) were oxidized by peracids to give the 2-oxides (231), while the 3-dialkylamino compounds (86c) afforded the 1-oxides (232) (77JOC546). 

The 2-chloro substituent may be exchanged for various nucleophiles. The 2-alkoxy derivatives were formed with alkali metal alkoxides,98,1 12,255,273 the 2-amino derivatives were formed with ammonia and amines,79,98,255, 260.283,285,286 t]ie 2-hydrazino derivatives were formed with hydrazine,98,255,283,287 and the 2-thiocyanatb derivatives were formed with alkali metal thiocyanates.283 2,3-Dichloro-4-oxo-4//-pyrido[l,2-fl]pyrimi-dine in phenol reacts with gaseous ammonia to yield a mixture of the 2-phenoxy and 2-amino derivatives, whereas with sodium hydroxide, the 2-phenoxy compound is obtained.255... 

Chemical Name 2-Butanol, 3-amino-l-(4-(2-methoxyethyl)phenoxy)-3-methyl-... 

Chemical Name Propanol, l-(l,l-(dimethylethyl)amino)-3-(2-((tetrahydro-2-furanyl)methoxy)phenoxy)-, hydrochloride... 

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